🎨Science Visuals | 🎯Targeted therapies are transforming treatment for #ColorectalCancer (#CRC)
🔸Key approaches include #EGFR inhibitors like #Cetuximab & #Panitumumab and #VEGF inhibition with #Bevacizumab.
🚫#Tumor growth and #angiogenesis.
#Cancer #CancerResearch #Oncology

🧬 5 terapias dirigidas innovadoras de China
🎯 5 mecanismos clave
🌍 1 objetivo: transformar el tratamiento del cáncer de pulmón

#CáncerDePulmón #CPNM #SaludPulmonar #TerapiaDirigida #Biotecnología #EGFR #ALK #ROS1 #Antiangiogénesis #PD1 #VEGF #InnovaciónChina #DengYueMedicinasEnHongKong

#Hypoxia-driven antigen loss and #VEGF secretion drive resistance to MUC16-targeted BITEs in #OvarianCancer, while VEGF blockade restores #cytotoxicity, highlighting #TumorMicroenvironment targeting to boost BITE immunotherapy. @harvardmed.bsky.social

#STTT: doi.org/10.1038/s413...

Hypoxia-driven #VEGF secretion promotes resistance to bispecific T-cell engagers by suppressing T-cell function, identifying VEGF inhibition as a viable strategy to enhance #Immunotherapy in #SolidTumors. @harvardmed.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

A novel bispecific antibody CVL006 superior to AK112 for dual targeting of PD-L1 and VEGF in cancer therapy Statement of Significance This project developed CVL006, a PD-L1/VEGF bispecific antibody combining an anti-PD-L1 VHH domain with an anti-VEGF IgG1. Precli

Antibody Therapeutics(IF=4.5, Oxford University Press)
🎇🎇A novel bispecific antibody CVL006 superior to AK112 for dual targeting of PD-L1 and VEGF in cancer therapy
academic.oup.com/abt/article/...
#BispecificAntibody #PDL1 #VEGF

#SummitTherapeutics has moved ahead in the race to bring a therapy targeting both #VEGF and #PDL1 to market, after the #FDA started a review of its ivonescimab drug for #lungcancer.

buff.ly/PtZy4pn

Hypoxia-driven MUC16/CA125 downregulation, #VEGF secretion, and #EMT emerge as #tumor-intrinsic mechanisms of resistance to MUC16-directed bispecific #TcellEngagers in #OvarianCancer, and VEGF blockade restores #cytotoxicity. @harvardmed.bsky.social

#STTT: doi.org/10.1038/s413...

Akeso Biopharma presenta la BLA de ivonescimab (anticuerpo biespecífico PD-1/VEGF) ante la FDA

📩 info@dengyuemed.com
🔗https://dengyuepharma.com

#Oncología #CáncerDePulmón #NSCLC #CPNM #EGFR #PD1 #VEGF #AnticuerpoBiespecífico #Ivonescimab #SummitTherapeutics #FDA

This review highlights #VEGF signaling as a regulator of vascular growth and repair, its dysregulation in #cancer, #cardiovascular and #ocular diseases, and the impact of VEGF‑targeted therapies, while addressing emerging strategies.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Researchers identify #hypoxia-driven #VEGF secretion & EMT as key resistance mechanisms to MUC16-targeted #BispecificTcellEngagers in #OvarianCancer, with VEGF inhibition restoring T-cell cytotoxicity and immunotherapy response. @harvardmed.bsky.social

#STTT: doi.org/10.1038/s413...

Patient and Physician Perspectives on the Management of Diabetic Macular Edema Gain patient and physician insights on managing diabetic macular edema, including current challenges with anti-VEGF injections, and emerging strategies to reduce treatment burden and improve outcomes.

How can #DME treatment challenges be overcome?

Gain patient and physician insights on managing DME, including current challenges with anti-VEGF injections, and emerging strategies to reduce treatment burden and improve outcomes.

👉 buff.ly/Y1HdDMM

#EyeMed #VEGF

#PainResearch #DrugDiscovery #NRP1 #VEGF @karapedsgastrodoc.bsky.social @margolislabnyu.bsky.social @pazduran.bsky.social

#UvealMelanoma cells with a GNA11Q209L or GNAQQ209L mutation secrete #VEGF to induce #EndothelialPermeability, facilitating UM cell transmigration across the endothelium, while systemic #Aflibercept & KAI treatment inhibit circulating UM cells.

#OpenAccess: doi.org/10.1038/s413...

This review summarizes #VEGF signaling in #VascularDevelopment and disease, highlighting progress in VEGF-targeted therapies, resistance mechanisms, and emerging strategies such as combination and smart delivery approaches. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

🌟 Discover #Avastin ( #Bevacizumab): Targeting Tumor Blood Supply!

❓ How does it block #VEGF and stop tumor growth?
⚡ Key therapy for #mCRC & #NSCLC.
💊 Trusted worldwide for cancer care.

🔗 Learn more: dengyuemed.com/product/avas...

#HongKongDrugWholesaleDistributor
#HongKongDengYueMedicine

🌟 #Yidafang (Ivonescimab):
Dual #PD-1 & #VEGF Target for #NSCLC! 🌟
💊 Boosts immunity,
blocks tumor growth,
improves survival.

🔗 Learn more: dengyuemed.com/product/ivon...

#HongKongDrugWholesaleDistributor #HongKongDengYueMedicine #Ivonescimab
#Immunotherapy #CancerTreatment

Epigenetics Update - Epigenetic modulation of BARD1 to enhance anti-VEGF therapy bit.ly/4mHSpnS

Findings uncover reveal how gene-specific epigenetic targeting overcomes AVA resistance

#Epigenetics #BreastCancer #Cancer #BARD1 #VEGF
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Discover the breakthrough at epigenometech.com

This review discusses #VEGF ligands and receptors, their molecular mechanisms, evaluates recent advances in VEGF-targeted therapies, and highlights the translational potential of new discoveries in VEGF biology. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Anti-VEGF therapy for wet macular degeneration - Lasker Foundation Explore All 2010 Winners & Awards > Napoleone Ferrara Genentech For the discovery of VEGF as a major mediator of angiogenesis and the development of an effective anti-VEGF therapy for wet macular…

Happy birthday to #LaskerLaureate Napoleone Ferrara, who discovered #VEGF, a major mediator of #angiogenesis. ow.ly/91SC50K2q7c
📖 a feature: laskerfoundation.org/visualizing-...
📺 his @a-p-s-a.bsky.social lecture: ow.ly/UzCg50K2q7e
🧪

Vascular endothelial growth factor-induced vascular permeability results in drastic and reversible hematopoietic stem cell mobilization Smith-Berdan et al. reveal that induced VEGF-induced vascular permeability results in hematopoietic stem cell mobilization from the marrow to the blood at unprecedented levels. This discovery demonstr...

#VEGF overexpression rapidly mobilizes functional #bonemarrow hematopoietic #stemcells to the blood stream and alters bone marrow vascular morphology. VEGF-induced mobilization is reversible bit.ly/3GrTkZH
@isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

This case report describes a patient with POEMS syndrome and Castleman disease, highlighting hypogonadism and subclinical hypothyroidism, and explores cytokine- and VEGF-mediated mechanisms underlying the associated endocrinopathies.
#IJCTM #POEMS #hypogonadism #VEGF
www.sciltp.com/journals/ijc...

After FDA says no, Bayer bags EU nod for twice-yearly Eylea Bayer has been given a leg up in the competitive market for VEGF therapies used to treat eye diseases with a new EU approval for Eylea 8mg.

#Bayer has been given a leg up in the competitive market for #VEGF therapies used to treat eye diseases like wet age-related macular degeneration (#AMD) with a new approval for #Eylea 8mg.

pharmaphorum.com/news/after-f...

Is #VEGF the true cause of macular degeneration and retinopathy? Find out on the @biorasi.bsky.social Few & Far Between podcast

Tune in today! Find this episode on your favorite streaming platform or visit >> bit.ly/FewandFarBet... #Biorasi2025 #YourGoToCRO #biotech #glycoltherapeutics

#oncology #3sbio #pfizer #pfizeroncology #sciencewillwin | Pharmaceutical Business Review International Pfizer announced it has entered into an exclusive global, ex-China, licensing agreement with 3SBio Inc., a leading Chinese biopharmaceutical company, for the development, manufacturing and commerciali...

📍 #Pfizer annonce un accord de licence mondial exclusif, avec #3SBio, pour le développement, la fabrication & la commercialisation de #SSGJ-707, un #AnticorpsBispécifique ciblant-1 et #VEGF, pour le #CancerDuPoumon, le #CancerColorectal & les #Tumeurs gynécologiques
www.linkedin.com/posts/pharma...

Angiogenesis: How New Blood Vessels Shape Health, Healing and Cancer - OncoDaily Angiogenesis, driven by VEGF and HIF-1α, forms blood vessels in healing, cancer, and ischemia—balancing pro- and anti-angiogenic signals shapes tumor growth and metastasis.

Angiogenesis: How New Blood Vessels Shape Health, Healing and Cancer

oncodaily.com/oncolibrary/...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Angiogenesis #HIF-1α #Hypoxia #VEGF #VEGFinhibitors

Structural Insights into Spare-Tire DNA G-Quadruplex from the Human VEGF Promoter The vascular endothelial growth factor (VEGF) promoter region, which is involved in cancer progression, contains guanine-rich sequences capable of forming G-quadruplex (G4) structures. G4s play a crit...

Another publication on DNA G-quadruplexes in collaboration with the Heckel group is out! 🎉

"Structural Insights into Spare-Tire DNA G-Quadruplex from the Human VEGF Promoter"

Full text: pubs.acs.org/doi/10.1021/...

#G4 #quadruplex #photocages #NMR #VEGF #structure

Linking preclinical models to clinical realities: VEGF/VEGFR inhibitors and thrombotic microangiopathy in cancer therapy This study investigates the risk of thrombotic microangiopathy (TMA) induced by vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) inhibitors in cancer ...

Linking preclinical models to clinical realities: VEGF/VEGFR inhibitors and thrombotic microangiopathy in #cancer therapy #iMetaOmics onlinelibrary.wiley.com/doi/full/10.... #VEGF #MedTwitter

Howard G. Smith MD, AM on Instagram: "Why Women Experience More Pain Than Men When a woman and a man both sustain injuries to their pain-generating nerves, only the woman produces a unique hormone t... 0 likes, 0 comments - drhowardsmithreports on April 2, 2025: "Why Women Experience More Pain Than Men When a woman and a man both sustain injuries to their pain-generating nerves, only the woman pro...

Why Women Experience More Pain Than Men: When a woman and a man both sustain injuries to their pain-generating nerves, only the woman produces a unique hormone that intensifies that pain. #pain #men #women #neuropathic #pannexin1 #leptin #vegf
www.instagram.com/drhowardsmit...

Opthea scraps wet AMD program after eye drug loses out to Lucentis in latest phase 3 fail Opthea’s eye disease drug has failed its se | Opthea’s eye disease drug has failed its second phase 3 trial in a week, leaving the Australian biotech to can the entire wet age-related macular…

Opthea scraps wet AMD program after eye drug loses out to Lucentis in latest phase 3 fail. Although, to be fair, it was a bit of a long shot, no? #AMD #VEGF

Long-term macular atrophy growth in neovascular age-related macular degeneration: influential factors and role of genetic variants - PubMed Most eyes with nAMD under 8 years of anti-VEGF therapy developed MA, with significant growth. Correlations with baseline MA characteristics and the ARMS2 variant were identified. Further…

Very interesting study looking into macular atrophy growth in patients on long-term anti-VEGF treatments. #AMD #VEGF

Long-term macular atrophy growth in neovascular age-related macular degeneration: influential factors and role of genetic variants buff.ly/ZpoU2OI