The increasing number of men presenting with functional #hypogonadism poses diagnostic challenges due to subtle clinical features and controversies in diagnostic serum #testosterone cut-offs www.thelancet.com/journals/lan...
#MensHealth

#MedSky #EndoSky

Male #hypogonadism is a clinical syndrome of impaired androgen production from the testes that is usually associated with impaired spermatogenesis and subfertility www.thelancet.com/journals/lan...
#testosterone #MensHealth

#MedSky #EndoSky #MensHealthSky

"We analysed Hitler’s DNA – and what we discovered made us gasp" Turi King and Alex J Kay have married genetics with history to study a sample of DNA from Adolf Hitler – and, as they reveal, their research has thrown up some extraordinary insights into the Nazi dic...

“… #Hitler … well-known deletion in a #gene that is associated with #KallmannSyndrome & the elaborately named #Congenital #hypogonadotropic #hypogonadism”
… genital organs were almost freakishly underdeveloped”
…
#polygenicscore placed him in the #top1% for schizophrenia, #autism & #bipolardisorder”

🍆🍒 BALLS #FullEpisode 11 | #steroidsideeffects #Hypogonadism #gynecomastia #steroids

https://youtu.be/_JHhNMwxx6o

Male #hypogonadism caused by an intrinsic & often irreversible HPT pathology is called organic (also termed classical) hypogonadism. Organic hypogonadism has a straightforward, established diagnostic & treatment pathway
www.thelancet.com/journals/lan...
#testosterone #MensHealth

#MedSky #EndoSky

Male #hypogonadism is a clinical syndrome of impaired androgen production from the testes that is usually associated with impaired spermatogenesis and subfertility www.thelancet.com/journals/lan...
#testosterone #menshealth

#MedSky #EndoSky #MensHealthSky

We have a fabulous finish with @konjikusicmia.bsky.social (@reiterlab.bsky.social, UCSF) on #GPCRs, #signaling, and #hypogonadism in #BBS models across the hypothalamus-pituitary-gonad axes and its many ciliated cell types! #Ciliopathies? www.biorxiv.org/content/10.1... #UKCilia2025 /6

Testosterone Treatment in Middle-Aged and Older Men with Hypogonadism | NEJM The authors review available data on the benefits and risks of testosterone treatment in middle-aged and older men with moderate hypogonadism.

#Medsky🧪 #publichealth @nejm.org
#Testosterone treatment in middle-aged and older men with #hypogonadism: pros & cons
www.nejm.org/doi/full/10....

PDF
www.nejm.org/doi/pdf/10.1...

Male hypogonadism: pathogenesis, diagnosis, and management Organic male hypogonadism due to irreversible hypothalamic–pituitary–testicular (HPT) pathology is easily diagnosed and treated with testosterone-replacement therapy. However, controversy surrounds th...

Organic #male #hypogonadism due to irreversible hypothalamic–pituitary–testicular (HPT) pathology is easily diagnosed and treated with #testosterone-replacement therapy www.thelancet.com/journals/lan...
#MensHealth #HPT axis

#MedSky #EndoSky

🎧 ÄrzteTag
Der hypogonadale Patient in der Hausarztpraxis (21min)
by Dr. Jörg Sandmann, Caroline...
Listen
Details
#Hypogonadism #PrimaryCare #MedicalConference

This case report describes a patient with POEMS syndrome and Castleman disease, highlighting hypogonadism and subclinical hypothyroidism, and explores cytokine- and VEGF-mediated mechanisms underlying the associated endocrinopathies.
#IJCTM #POEMS #hypogonadism #VEGF
www.sciltp.com/journals/ijc...

Gotta read this stuff while on the stationary bike so I don't fall asleep #USPharmacist article on #hypogonadism for a #pharmacy to #compound #menshealth

Reversal of congenital hypogonadotropic hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation The identification and characterisation of kisspeptin represents a milestone in our understanding of the mechanisms underlying gonadotropin-releasing hormone (GnRH) neurosecretion.1,2 Kisspeptin is th...

Abrogation of #kisspeptin does not prevent #GnRH late activation and #hypogonadism reversal, indicating the pervasive and redundant nature of neuropeptides and mediators operating upstream of GnRH www.thelancet.com/journals/lan...
#hypogonadotropic #hypogonadism
#FREE to read

#MedSky #EndoSky

Reversal of congenital hypogonadotropic hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation The identification and characterisation of kisspeptin represents a milestone in our understanding of the mechanisms underlying gonadotropin-releasing hormone (GnRH) neurosecretion.1,2 Kisspeptin is th...

New Research Letter:

Reversal of #congenital #hypogonadotropic #hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation www.thelancet.com/journals/lan... #CHH #kisspeptin
#FREE to read

#MedSky #EndoSky #GeneticSky

Gonadotropin Therapy for Mini-Puberty Induction in Male Infants With Hypogonadotropic Hypogonadism AbstractContext. Congenital hypogonadotropic hypogonadism (CHH) is defined as an isolated deficiency of gonadotropin hormones. Mini-puberty, a transient po

Gonadotropin therapy for mini-puberty induction in male infants with hypogonadotropic #hypogonadism. #pediatrics #DSD Featured study in #JCEM #FreeToView
doi.org/10.1210/clin...
@endocrinesociety.bsky.social

Organic #male #hypogonadism due to irreversible hypothalamic–pituitary–testicular (HPT) pathology is easily diagnosed and treated with #testosterone-replacement therapy www.thelancet.com/journals/lan...
#MensHealth
#MedSky #EndoSky

Going to restart using Nebido (testosterone undecanoate)
Going to take it every 8 weeks. Hopefully it should give a slightly higher and more stable testosterone level.

#kallmann #hypogonadism #hypogonadotropic #testosterone #hormonereplacementtherapy #nebido #undecanoate #puberty #latebloomer

There is perhaps a reason I do not put myself in these videos often but I do like talking about Kallmann syndrome to help raise awareness of the condition. Kallmann syndrome is a rare genetic hormonal... TikTok video by Neil Smith

Kallmann syndrome is a rare genetic hormonal condition that affects puberty & fertility. Associated with a lack of sense of smell.

www.tiktok.com/@neilsmith38...

#rarediseaseday #rarediseaseday2025 #kallmann #puberty #hypogonadism #hypogonadotropic #hormone #infertility #anosmia #endocrinology

Kallmann syndrome - not a late bloomer.

#rarediseaseday2025 #rarediseaseday #rarediseaseawareness #kallmannsyndrome #kallmann #hypogonadotropichypogonadism #hypogonadism #puberty #infertility #anosmia #latebloomer #hormonereplacementtherapy #endocrinology #hypothalamus #testosterone #oestrogen

#rarediseaseday2025 #raredisease #kallmann #hypogonadotropic #hypogonadism #puberty #infertility #anosmia #gonadotropin

Kallmann syndrome - a form of hypogonadotropic hypogonadism.

Rare hormone condition that prevents normal puberty and fertility.

#rarediseaseday #rarediseaseday2025 #kallmannsyndrome #kallmann #hypogonadism #hypogonadotropichypogonadism #puberty #anosmia #hormonereplacementtherapy #endocrinology

Kallmann syndrome - a form of hypogonadotropic hypogonadism.

Rare hormone condition that prevents normal puberty and fertility.

#rarediseaseday #rarediseaseday2025 #kallmannsyndrome #kallmann #hypogonadism #hypogonadotropichypogonadism #puberty #anosmia #hormonereplacementtherapy #endocrinology

Gonadal function and pathology in 17beta-HSD 3 and 5alpha-reductase deficiency AbstractObjective. 17β-Hydroxysteroid dehydrogenase 3 deficiency (17β-HSDD) and 5α-reductase type 2 deficiency (5α-RD) are rare 46,XY differences of sex de

Gonadal function and pathology in 17beta-HSD type 3 and 5alpha-reductase deficiency by Lidewij S Boogers et al

EJE Volume 192, Issue 1, January 2025
Open access paper 👉 doi.org/10.1093/ejen...

#endocrinology #hypogonadism

youtu.be/d_jIk5zyaVU?...
#youtube #shorts #vlog #hypogonadism

youtu.be/N4zR9MaQWAs?...
#youtube #vlog #hypogonadism

youtu.be/iU-tXxgXjf8?...
#youtube #vlog #hypogonadism

Male hypogonadism: pathogenesis, diagnosis, and management Organic male hypogonadism due to irreversible hypothalamic–pituitary–testicular (HPT) pathology is easily diagnosed and treated with testosterone-replacement therapy. However, controversy surrounds th...

Male #hypogonadism: pathogenesis, diagnosis, and management thelancet.com/journals/lan...
#MensHealth #testosterone

Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating...

#GnRH deficiency is perhaps a better term to describe both #Kallmann syndrome & #hypogonadotropic #hypogonadism.

Kallmann syndrome / HH is a secondary hypogonadism condition due to a disruption in GnRH production preventing correct gonadotropin release.

www.ncbi.nlm.nih.gov/books/NBK1334/

Said this yesterday, but I'll sum it up here. While doing some research with my own blood and with the help of my GP and another specialist...I might have #hypoandrogenism & #hypogonadism. Which explains a lot of things about my #gender identity crisis and my lack of sexuality. #Asexuality

Contributions of Common Genetic Variants to Constitutional Delay of Puberty and Idiopathic Hypogonadotropic Hypogonadism AbstractContext. Constitutional delay of puberty (CDP) is highly heritable, but the genetic basis for CDP is largely unknown. Idiopathic hypogonadotropic h

Contributions of common genetic variants to constitutional delay of #puberty and idiopathic hypogonadotropic #hypogonadism.
doi.org/10.1210/clin...
Featured study in #JCEM. #FreeToView
#genetics #KallmanSyndrome
@endocrinesociety.bsky.social