"We analysed Hitler’s DNA – and what we discovered made us gasp" Turi King and Alex J Kay have married genetics with history to study a sample of DNA from Adolf Hitler – and, as they reveal, their research has thrown up some extraordinary insights into the Nazi dic...

“… #Hitler … well-known deletion in a #gene that is associated with #KallmannSyndrome & the elaborately named #Congenital #hypogonadotropic #hypogonadism”
… genital organs were almost freakishly underdeveloped”
…
#polygenicscore placed him in the #top1% for schizophrenia, #autism & #bipolardisorder”

Reversal of congenital hypogonadotropic hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation The identification and characterisation of kisspeptin represents a milestone in our understanding of the mechanisms underlying gonadotropin-releasing hormone (GnRH) neurosecretion.1,2 Kisspeptin is th...

Abrogation of #kisspeptin does not prevent #GnRH late activation and #hypogonadism reversal, indicating the pervasive and redundant nature of neuropeptides and mediators operating upstream of GnRH www.thelancet.com/journals/lan...
#hypogonadotropic #hypogonadism
#FREE to read

#MedSky #EndoSky

Reversal of congenital hypogonadotropic hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation The identification and characterisation of kisspeptin represents a milestone in our understanding of the mechanisms underlying gonadotropin-releasing hormone (GnRH) neurosecretion.1,2 Kisspeptin is th...

New Research Letter:

Reversal of #congenital #hypogonadotropic #hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation www.thelancet.com/journals/lan... #CHH #kisspeptin
#FREE to read

#MedSky #EndoSky #GeneticSky

TikTok - Make Your Day

www.tiktok.com/@neilsmith38...

I was still labelled as a "late bloomer" at the age of 20. I did not get the correct diagnosis of having #Kallmann syndrome until I was 23.

Kallmann syndrome is a form of #hypogonadotropic hypogonadism that prevents puberty from occurring correctly.

Going to restart using Nebido (testosterone undecanoate)
Going to take it every 8 weeks. Hopefully it should give a slightly higher and more stable testosterone level.

#kallmann #hypogonadism #hypogonadotropic #testosterone #hormonereplacementtherapy #nebido #undecanoate #puberty #latebloomer

We are creating a channel on You Tube where I will be asking a Kallmann medical expert some frequently asked questions on #Kallmann syndrome and #Hypogonadotropic Hypogonadism.

We aim to produce a series of 3 - 5 minute videos to help raise awareness of the condition.

youtu.be/QDfpA8NsoFY?...

Kallmann's Syndrome /r/kallmann_syndrome is a Subreddit dedicated to mutual support and aide of fellow Kallmann's patients. In addition, it serves as a point of public education, and discussion of the effects of Kallmann...

We have patient groups on Reddit and Facebook where you can talk to other patients with #Kallmann syndrome and #Hypogonadotropic hypogonadism.

www.reddit.com/r/kallmann_s...

There is perhaps a reason I do not put myself in these videos often but I do like talking about Kallmann syndrome to help raise awareness of the condition. Kallmann syndrome is a rare genetic hormonal... TikTok video by Neil Smith

Kallmann syndrome is a rare genetic hormonal condition that affects puberty & fertility. Associated with a lack of sense of smell.

www.tiktok.com/@neilsmith38...

#rarediseaseday #rarediseaseday2025 #kallmann #puberty #hypogonadism #hypogonadotropic #hormone #infertility #anosmia #endocrinology

#rarediseaseday2025 #raredisease #kallmann #hypogonadotropic #hypogonadism #puberty #infertility #anosmia #gonadotropin

Current landscape of fertility induction in males with congenital hypogonadotropic hypogonadism You have to enable JavaScript in your browser's settings in order to use the eReader.

nyaspubs.onlinelibrary.wiley.com/share/H6CMMN...

Kallmann syndrome / hypogonadotropic hypogonadism affects normal puberty and fertility in both males & females.

Fertility treatments are available in the form of gonadotropin therapy.
#kallmann #hypogonadotropic #infertility #puberty #gonadotropin

For Rare Disease Day. Kallmann syndrome is a hormone condition where puberty fails to start correctly. I also have no sense of smell and poor hearing. I was incorrectly labelled as a “late bloomer” a... TikTok video by Neil Smith

www.tiktok.com/@neilsmith38...

#kallmann #hypogonadotropic #puberty #latebloomer #rarediseaseday #raredisease #testosterone #anosmia #infertility

I was diagnosed with #kallmannsyndrome when I was 23 years old, after being misdiagnosed as being a "late bloomer".

This is one of the first You Tube videos I created, 15 years ago.

youtu.be/NdugznakBGo?...

#puberty #kallmann #hypogonadotropic #infertility #anosmia

Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating...

#GnRH deficiency is perhaps a better term to describe both #Kallmann syndrome & #hypogonadotropic #hypogonadism.

Kallmann syndrome / HH is a secondary hypogonadism condition due to a disruption in GnRH production preventing correct gonadotropin release.

www.ncbi.nlm.nih.gov/books/NBK1334/

Mini-Puberty, Physiological and Disordered: Consequences, and Potential for Therapeutic Replacement There are 3 physiological waves of central hypothalamic-pituitary-gonadal (HPG) axis activity over the lifetime. The first occurs during fetal life, the second—termed “mini-puberty”—in the first month...

Patients with #Kallmann syndrome / #hypogonadotropic hypogonadism do not experience #mini-puberty, the post natel hormone surge around 3 to 6 months of age.

Testing at this stage can offer a chance of early diagnosis and treatment for male patients.

pmc.ncbi.nlm.nih.gov/articles/PMC...

#Kallmann syndrome is a form of a condition called #hypogonadotropic hypogonadism (HH).

There is a failure in the production of hormones that control puberty and fertility.

It is not the same condition as delayed puberty or being a "late bloomer".