Hi all! 👋
Looking for a plasmid with the gnrh3 promoter driving a FP (GFP or similar) 🐟
The construct itself — not a transgenic fish line.
Does anyone have it or know a lab that does? 🙏
#zebrafish #GnRH #neurodev #AcademicSky #developmentalBiology #neuroscience

A Novel Peptide, HS1002, Enhances Antitumor Activity via Dual Targeting of the GnRH Receptor and Human Telomerase Reverse Transcriptase in Prostate Cancer Cells HS1002, a new peptide targeting GnRHR and hTERT, demonstrates significant Anticancer activity in prostate cancer cells. The mechanism of HS1002 can be attributed to the reduction of serum testosteron...

#Article in #MedComm

A Novel #Peptide, #HS1002, Enhances #Antitumor Activity via Dual Targeting of the #GnRH Receptor and Human #Telomerase Reverse Transcriptase in Prostate Cancer Cells doi.org/10.1002/mco2...

Research team from Sungkyunkwan University

#hTERT #ImmuneResponse #ProstateCancer

⚖️ #Agonistas vs. #Antagonistas de #GnRH
En el tratamiento del cáncer de próstata:
✔ Efecto “flare” vs. sin “flare”
✔ Acción progresiva vs. rápida
✔ Diferentes vías de administración

#CáncerDePróstata
#TerapiaGnRH #ADT #SupresiónDeTestosterona #EducaciónMédica #DengYueMedicinasEnHongKong

🎉 Honoured to have delivered the Ernst Knobil Distinguished Lecture! Huge thanks to Ludmila Filaretova for the warm and thoughtful introduction, and to everyone who joined—your energy made it unforgettable! So excited about the bright future of integrative physiology! 🚀 #IUPS #GnRH #Cognition

Day 2 started with the Symposium on #Rhythms and Hormonal Interactions.

"Looking forward to talks on #Chrononutrition, #astrocytes and metabolic control, retinal ganglion cell-> #SCN rhythms, and brainstem regulation of #GnRH pulse generator. 🕘🍔🧠 "

- Dr Rebecca Dumbell @rebeccadumbell.bsky.social

Day 2 of #BSNbradford2025 I'm co-chairing session 1: #Rhythms and Hormonal interactions 9am. Looking forward to talks on #Chrononutrition, #astrocytes and metabolic control, retinal ganglion cell-> #SCN rhythms, and brainstem regulation of #GnRH pulse generator. 🕘🕥🍔🧠 @bsneuroendo.bsky.social

Neurotrophic Effects of GH and GnRH in a Full Sciatic Nerve Transection Model in Male Rats <p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d2624021e215"> <b> <i>Introduction:</i> </b>...

'Neurotrophic Effects of #GH and #GnRH in a Full Sciatic Nerve Transection Model in Male Rats' - a @kargerpublishers.bsky.social #Endocrinology article on #ScienceOpen:

🖇️ #Neuroendocrinology #Neuroregeneration #PeripheralNerveRepair

Reversal of congenital hypogonadotropic hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation The identification and characterisation of kisspeptin represents a milestone in our understanding of the mechanisms underlying gonadotropin-releasing hormone (GnRH) neurosecretion.1,2 Kisspeptin is th...

Abrogation of #kisspeptin does not prevent #GnRH late activation and #hypogonadism reversal, indicating the pervasive and redundant nature of neuropeptides and mediators operating upstream of GnRH www.thelancet.com/journals/lan...
#hypogonadotropic #hypogonadism
#FREE to read

#MedSky #EndoSky

GnRH—Gonadotropes Interactions Revealed by Pituitary Single-cell Transcriptomics in Zebrafish Abstract. GnRH governs reproduction by regulating pituitary gonadotropins. Unlike most vertebrates, gnrh−/− zebrafish are fertile. To elucidate the role of

#GnRH —gonadotropes interactions revealed by #pituitary single-cell #transcriptomics in #zebrafish. Featured study in #Endocrinology. #FreeToView #SexualDevelopment
@endocrinesociety.bsky.social
doi.org/10.1210/endo...

Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating...

#GnRH deficiency is perhaps a better term to describe both #Kallmann syndrome & #hypogonadotropic #hypogonadism.

Kallmann syndrome / HH is a secondary hypogonadism condition due to a disruption in GnRH production preventing correct gonadotropin release.

www.ncbi.nlm.nih.gov/books/NBK1334/