DUSP6 ablation restores CAR T-cell fitness impaired by tumor CD58 loss through invigoration of AP-1 signaling
Ablating DUSP6 invigorates AP-1 signaling to restore CAR T-cell metabolic fitness, proliferation and #Cytotoxicity, providing a strategic engineering target to bypass tumor CD58-mediated immune resistance.
#STTT #OpenAccess: doi.org/10.1038/s413...
#Hypoxia-driven antigen loss and #VEGF secretion drive resistance to MUC16-targeted BITEs in #OvarianCancer, while VEGF blockade restores #cytotoxicity, highlighting #TumorMicroenvironment targeting to boost BITE immunotherapy. @harvardmed.bsky.social
#STTT: doi.org/10.1038/s413...
Model describing the effect of CUL5 on the sensitivity of bladder cancer cells to CD8+ T cell-mediated killing. CUL5-KO could reduce the ubiquitination of PTBP1, thereby increasing the alternative splicing of RUBCN pre-mRNA, leading to an increase in Rubicon-S which inhibits autophagy, and thus enhances the sensitivity of bladder cancer cells to CD8+ T cell-mediated killing (cartoon created in BioRender).
CD8+ T cells can target & eliminate malignant #tumor cells, but tumors can develop resistance mechanisms to escape them. This study shows that loss of the E3 #ubiquitin ligase CUL5 enhances CD8+ #Tcell #cytotoxicity & anti PD-1 efficacy by inhibiting #autophagy @plosbiology.org 🧪 plos.io/3Mv1EuR
Model describing the effect of CUL5 on the sensitivity of bladder cancer cells to CD8+ T cell-mediated killing. CUL5-KO could reduce the ubiquitination of PTBP1, thereby increasing the alternative splicing of RUBCN pre-mRNA, leading to an increase in Rubicon-S which inhibits autophagy, and thus enhances the sensitivity of bladder cancer cells to CD8+ T cell-mediated killing (cartoon created in BioRender).
CD8+ T cells can target & eliminate malignant #tumor cells, but tumors can develop resistance mechanisms to escape them. This study shows that loss of the E3 #ubiquitin ligase CUL5 enhances CD8+ #Tcell #cytotoxicity & anti PD-1 efficacy by inhibiting #autophagy @plosbiology.org 🧪 plos.io/3Mv1EuR
Model describing the effect of CUL5 on the sensitivity of bladder cancer cells to CD8+ T cell-mediated killing. CUL5-KO could reduce the ubiquitination of PTBP1, thereby increasing the alternative splicing of RUBCN pre-mRNA, leading to an increase in Rubicon-S which inhibits autophagy, and thus enhances the sensitivity of bladder cancer cells to CD8+ T cell-mediated killing (cartoon created in BioRender).
CD8+ T cells can target & eliminate malignant #tumor cells, but tumors can develop resistance mechanisms to escape them. This study shows that loss of the E3 #ubiquitin ligase CUL5 enhances CD8+ #Tcell #cytotoxicity & anti PD-1 efficacy by inhibiting #autophagy @plosbiology.org 🧪 plos.io/3Mv1EuR
Biogenic synthesized selenium nanoparticles combined chitosan nanoparticles controlled lung cancer growth via ROS generation and mitochondrial damage pathway
#Greensynthesis of selenium and selenium–chitosan #nanoparticles using #GrapeSeedExtract demonstrates selective, dose-dependent #cytotoxicity in lung cancer cells via #ROS-mediated mitochondrial dysfunction and #apoptosis. #anticancer
Nanotechnology Reviews: doi.org/10.1515/ntre...
Scientists highlight how #lncRNAs regulate #NKcell development, activation, #cytotoxicity, and #TumorInfiltration via transcriptional control, #miRNA sponging, metabolism, ubiquitination, and epigenetics, highlighting their therapeutic potential.
#OpenAccess: doi.org/10.1016/j.ge...
Hypoxia-driven MUC16/CA125 downregulation, #VEGF secretion, and #EMT emerge as #tumor-intrinsic mechanisms of resistance to MUC16-directed bispecific #TcellEngagers in #OvarianCancer, and VEGF blockade restores #cytotoxicity. @harvardmed.bsky.social
#STTT: doi.org/10.1038/s413...
Synthesis and characterization of zinc sulfide nanoparticles and their genotoxic and cytotoxic effects on acute myeloid leukemia cells
ZnS #nanoparticles fabricated via #ThermalDecomposition exhibit high colloidal stability and selective #cytotoxicity, reducing #cancercell viability through #ROS generation, mitochondrial depolarization, and #apoptosis. #Nanomedicine
#OpenAccess Open Chemistry: doi.org/10.1515/chem...
Relapsed #AML drives #NKCell exhaustion via the NKG2A/HLA‑E axis and PI3K‑AKT suppression; blocking NKG2A or restoring #AktPhosphorylation enhances #cytotoxicity, highlighting a strategy to optimize NK cell‑based #immunotherapies. @pku1898.bsky.social
#STTT: doi.org/10.1038/s413...
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Many heating coils contained heavy metals such as copper, iron, aluminum, silver, and titanium. The study noted that these metals can increase the risk of inflammation and #cytotoxicity, which causes cell death or severe damage—once inhaled.
#HealthRisks
#HomeAppliances
#HouseholdAppliances
Green-synthesized royal jelly–selenium #nanoparticles show strong stability, potent #antimicrobial effects, and notable #cytotoxicity, outperforming raw #RoyalJelly and emerging as a promising multifunctional therapeutic candidate.
Nanotechnology Reviews: doi.org/10.1515/ntre...
🧬Molecule of the Moment | Another major breakthrough: #CDH17-targeting #ADC #7MW491 that conjugates Topi MF-6 via a cleavable linker, specifically designed to tackle the #MDR challenge in #GI tumors.
#TopiMF-6 #GastrointestinalTumor #Cytotoxicity #HighSpecificity
Bioactivity of Decavanadate Compounds: Can Their In Vitro and In Vivo Effects Be Assessed in a Simple Manner? | Inorganic Chemistry pubs.acs.org/doi/10.1021/... Pessoa, López, and co-workers @InorgChem #decavanade #DFT #bioactivity #cytotoxicity #hydrolysis
#SUMOylation inhibitor TAK-981 suppresses #BurkittsLymphoma (BL) and enhances #CD19 #CARTcell therapy by promoting Th2 polarization and boosting #cytotoxicity, highlighting the potential of SUMOylation blockade to overcome refractory BL.
#OpenAccess #STTT: doi.org/10.1038/s413...
🧬 Detect apoptosis & necrosis in real time: no dyes, no bias.
Nanolive’s AI-powered, label-free LIVE Cytotoxicity Assay tracks cell death & health phenotypes continuously & non-invasively.
Discover more: bit.ly/47rrLdK
#CellPainting #Cytotoxicity #Nanolive
CUDC-907 is a highly potent dual PI3K/HDAC inhibitor that exhibits excellent #cytotoxicity and high selectivity against MEF2D fusion–expressing B-cell precursor acute lymphoblastic #leukemia (#BCPALL) cells. #medsky
#OpenAccess: doi.org/10.1038/s413...
Vertex Engineering of the Dodecaborate-Based Broadband Membrane Carriers | Inorganic Chemistry pubs.acs.org/doi/10.1021/... @organomimetic and co-workers @InorgChem #perhalogenated #boron #clusters #dodecaborate #vertex #cytotoxicity #membrane #carriers #transport #hydrophilicity
Relapsed #AML drives #NKCell exhaustion via NKG2A/HLA-E–mediated suppression of the PI3K-AKT pathway, while NKG2A blockade restores AKT signaling & #cytotoxicity, offering a strategy to boost NK cell–based #immunotherapy. @pku1898.bsky.social
#OpenAccess: doi.org/10.1038/s413...
Baicalein Sensitizes Triple Negative Breast Cancer Cells to Cisplatin by Activating Apoptosis
@naturalproductcomm.bsky.social
@journals.sagepub.com
journals.sagepub.com/doi/10.1177/...
#cytotoxicity #cancerresearch #oncosky #oncology #openaccess
From images to data: quantifying cytotoxicity.
Nanolive transforms imaging into real-time metrics, capturing cell dynamics missed by endpoint assays.
👉 Learn more about the 3D Cell Explorer 96focus: bit.ly/3JScCcd
#Cytotoxicity #DrugDiscovery #Imaging
Dynamic, label-free classification of cell death. Nanolive’s LIVE Cytotoxicity Assay distinguishes living, apoptotic & necrotic cells in real time, uncovering subtle drug effects missed by traditional methods.
🔗 bit.ly/474Y0zN
🎥 Ebastine effect on fibroblasts over 20h
#Cytotoxicity #DrugDiscovery
Understanding drug effects in co-culture is key for discovery
Nanolive’s LIVE Cytotoxicity Assay delivers real-time, label-free insights into how healthy & cancer cells respond side by side
📊 Track apoptosis, necrosis & viability in 1 experiment
🔗 bit.ly/4fOW6p2
#Cytotoxicity #DrugDiscovery
How fast do T cells engage? How sustained is their killing? Traditional assays can’t answer.
Nanolive’s LIVE T Cell Assay reveals T cell–mediated killing in real time: label-free & dynamic.
🔗 bit.ly/3VbNUWv
#TCells #ImmunoOncology #Cytotoxicity
Cytotoxicity matters for drug discovery & safety testing. Most assays only give static snapshots. Nanolive lets you track cells dynamically: swelling, vacuolization & death, all label-free & in real time.
👉 bit.ly/3JsQjJZ
#Cytotoxicity #Imaging #Innovation
🚨 New marine natural product!
The @mehiri_group reports amesilide, a novel bicyclic polyketide from the marine fungus Amesia nigricolor MUT6601.
#Amesia nigricolor #cytochalasan #polyketide #bis-naphtho-γ-pyrone #antimicrobia #cytotoxicity
www.mdpi.com/1420-3049/30...
Pitfalls in cytotoxicity studies could be tripping up chemists #Science #Chemistry #Biochemistry #Cytotoxicity #ChemistryResearch #LabSafety
#MSLASpheroidStamp: #OpenSource 3D #cell #spheroids for everyone:
- #3Dprinted molds/stamps
- time-lapse #confocal #microscopy of spheroids
- #cytotoxicity screens
Preprint: doi.org/10.1101/2024...
GitHub: github.com/arteys/MSLAS...
#DIYbio #lab #instruments #MSLA #3Dprinting #bioprinting #imaging
Profiling of #cytotoxicity across immune subsets and tissues from single-cell RNA seq data. NKG7 expression is a strong marker of cytotoxicity, surpassing traditional markers such as granzyme B and perforin. Can't wait t try on on our TILs.
onlinelibrary.wiley.com/share/GYGB67...
