Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia

Relapsed #AML drives #NKCell exhaustion via the NKG2A/HLA‑E axis and PI3K‑AKT suppression; blocking NKG2A or restoring #AktPhosphorylation enhances #cytotoxicity, highlighting a strategy to optimize NK cell‑based #immunotherapies. @pku1898.bsky.social

#STTT: doi.org/10.1038/s413...