#Highlight in #MedComm_Oncology
#Metabolic Reprogramming of the Pre-Metastatic Niche: A Sweet Spot for Anti-#Tumor #Immunity doi.org/10.1002/mog2...

The highlighted article in @CellCellPress : doi.org/10.1016/j.ce...

#LowCarbohydrateDiet #Lung #Metastasis #macrophage #NKcell

Interferon stimulation and NKG2D expression drive enhanced natural killer cell antibody-dependent cellular cytotoxicity against viral infections Integrated single-cell transcriptomics and functional assays reveal interferon signaling and NKG2D expression as drivers of antibody-dependent cellular cyt

Leslie Chan @stanfordimmunology.bsky.social, Catherine Blish @blishlab.bsky.social and colleagues @stanfordmedicine.bsky.social identify #Interferon activation and #NKG2D expression as key determinants of #NKcell antibody-dependent cellular cytotoxicity (#ADCC) in #SARS-CoV-2 infection

Scientists highlight how #lncRNAs regulate #NKcell development, activation, #cytotoxicity, and #TumorInfiltration via transcriptional control, #miRNA sponging, metabolism, ubiquitination, and epigenetics, highlighting their therapeutic potential.

#OpenAccess: doi.org/10.1016/j.ge...

A phase 1b/2 trial shows that #allogeneic #NKcell therapy plus #chemotherapy is safe in #AdvancedPancreaticCancer, with 31.6% response; #MultiomicProfiling reveals NK/T‑cell subsets linked to outcomes, offering novel immune insights.

#OpenAccess in STTT: doi.org/10.1038/s413...

#Article in #MedComm
Low Dose of #IL_2 Application for Graft-Versus-Host Disease (#GVHD) Prophylaxis Following Haploidentical Stem Cell Transplantation doi.org/10.1002/mco2...

#Tregs #interleukin_2 #NKcell

Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia

Relapsed #AML drives #NKCell exhaustion via the NKG2A/HLA‑E axis and PI3K‑AKT suppression; blocking NKG2A or restoring #AktPhosphorylation enhances #cytotoxicity, highlighting a strategy to optimize NK cell‑based #immunotherapies. @pku1898.bsky.social

#STTT: doi.org/10.1038/s413...

Cayatte, Picant, Vétizou, & Vivier @ciml.bsky.social review current insights into human #NKcell heterogeneity and function, their roles in viral #infection, #autoimmunity, #neurodegeneration, and #transplantation, and the emerging therapeutic opportunities they offer. rupress.org/jem/article/...

#ACAT1 acquires a nuclear role in #ColorectalCancer, where S60 phosphorylation enables p50 acetylation, relieves #NFκB repression, enhances #NKcell recruitment, while nutrient stress blocks this axis and drives #ImmuneEvasion and poor prognosis.

#STTT: doi.org/10.1038/s413...

@drnicolecampbell.bsky.social once again wowing us with a showstopper at the @ciiid-hudson.bsky.social Xmas party. Individual macarons shaped like different the cells we work on, including #macrophage #neuron #NKcell #astrocyte #bacteria #virus
Amazing! 🧪👩‍🍳

Loss of #EHMT2 enhances #NKcell -driven #AntiTumorImmunity through #TGFβ1 suppression

by S. Chava, R. Gupta, N. Wajapeyee & colleagues
@uofalabama.bsky.social

doi.org/10.1038/s443...

Feeling great to have presented my work at #ASH25. What an amazing conference this has been! Thank you for the wonderful opportunity! Looking forward to the ASH meeting next year and hope to showcase again our work from @danafarber.bsky.social
#Hematology #leusm #lymsm #ashawards #NKCell

Excited to give an Oral Presentation of my work at the @ash.hematology.org Annual Meeting in Orlando, Florida on Dec 6th. Happy to have received the #AbstractAchievementAward
Looking forward to a great meeting and scientific discussions!
#ASH25 #ASHAwards #NKCell #Lymsm #Leusm #ImmunOnc #Hematology

TSC22D3 deficiency enhances #NKcell function, shifting immune responses to CD8+ T cells via cytokine- and contact-dependent pathways, highlighting TSC22D3-regulated NK cells as key regulators of SCARs #Pathogenesis.

#STTT #OpenAccess: doi.org/10.1038/s413...

STAT3 regulates NK and NKT cell differentiation through C-X3-C motif chemokine receptor 1  (CX3CR1) in hyper-IgE syndrome - Molecular Biomedicine Mutations in the signal transducer and activator of transcription 3 (STAT3) gene are strongly associated with Hyper-IgE Syndrome (HIES), a rare immunodeficiency disorder characterized by elevated leve...

#Research
STAT3 regulates NK and NKT cell differentiation through C-X3-C motif chemokine receptor 1 (CX3CR1) in hyper-IgE syndrome doi.org/10.1186/s435...

#STAT3 #mutation #Hyper_IgE #syndrome #NKcell #CX3CR1

This review shows that #lncRNAs govern #NKcell biology in #Pathological conditions, and highlights that their regulatory role in the #TumorMicroenvironment positions them as novel #therapeutic targets in NK cell #Dysfunction. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

This review shows that #lncRNAs govern #NKcell biology in #Pathological conditions, and highlights that their regulatory role in the #TumorMicroenvironment positions them as novel #therapeutic targets in NK cell #Dysfunction. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

Relapsed #AML drives #NKCell exhaustion via NKG2A/HLA-E–mediated suppression of the PI3K-AKT pathway, while NKG2A blockade restores AKT signaling & #cytotoxicity, offering a strategy to boost NK cell–based #immunotherapy. @pku1898.bsky.social

#OpenAccess: doi.org/10.1038/s413...

This review focuses on the interaction between #lncRNAs and #NKCell biology, highlighting its potential as a therapeutic target in diseases involving NK cell dysfunction. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

Yan Leyfman: Boosting CAR-T/NK Cell Persistence via the FAS Pathway - OncoDaily Yan Leyfman: Boosting CAR-T/NK Cell Persistence via the FAS Pathway / cancer, Christopher A. Klebanoff, Christopher S Hackett, Doron Betel, Dr. Christopher A.

Boosting CAR-T/NK Cell Persistence via the FAS Pathway - Yan Leyfman
@yleyfman.bsky.social

oncodaily.com/blog/yan-ley...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #CART #NKCell

Happy to announce a post doc (lnkd.in/d4cZvybV) and a PhD position (lnkd.in/dqU6NFmt) in my lab, available from Sept 1. Join us to dive into mechanisms of #NKcell killing of cancer via #extracellularvesicles! Tightly linked to innovation activities. @sni-nkmeeting.bsky.social @isev.org @uio.no

Derivation of ImmunityBio's Car-NK strategy
After AI research, a potential strategy for ImmunityBio's future NK-92 and CAR-NK platform can be inferred from several clues provided by three new AACR25 abstract posters.
#CARNK #immunology #NKcell #immunosky
Details:
cloud.hoststar.ch/s/FG546bHA6w...

Allogeneic NK cells with a bispecific innate cell engager in refractory relapsed lymphoma: a phase 1 trial - Nature Medicine In this phase 1 trial, patients with heavily pretreated and refractory CD30+ lymphoma were safely treated with donor-cord-blood-derived NK cells that were precomplexed with the anti-CD30 and anti-CD16...

🌟NEW in #NatureMedicine! Work led by Yago Nieto & Katy Rezvani @mdanderson.bsky.social shows bispecific antibody-activated cord blood-derived #NKcell #immunotherapy is safe w/ a preliminary efficacy signal in patients w/ #lymphoma #OncSky @natureportfolio.nature.com www.nature.com/articles/s41...

Ammonia: A Hidden Obstacle in Cancer Immunotherapy - Yan Leyfman
@yleyfman.bsky.social

oncodaily.com/science/2665...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Ammonia #Immunotherapy #CART #NaturaKillerCells #NKcell

Maria (Masha) Babak: How fasting reshapes NK cell biology to enhance anti-tumor immunity - OncoDaily Maria (Masha) Babak: How fasting reshapes NK cell biology to enhance anti-tumor immunity / cancer, cancer therapy, fight against cancer, Global fight against

How fasting reshapes NK cell biology to enhance anti-tumor immunity - Maria (Masha) Babak
@thebabaklab.bsky.social

oncodaily.com/blog/255068-...

#Cancer #CancerResearch #CancerTreatment #FightAgainstCancer #NKCell #Medicine #Health #Oncology #OncoDaily

Harnessing natural killer cell effector function against cancer Summary. Natural killer (NK) cells are cytotoxic innate lymphoid cells that participate in anti-tumour and anti-viral immune responses. Their ability to ra

💥 Curious about #NKCells' role in targeting tumours? @unisouthampton researchers review advances in #NKcell #immunotherapy, including CAR-NK cells, NK cell engagers, cytokines & checkpoint inhibitors: 🔗 doi.org/10.1093/imma... (4/8)

Big shout out to one of our PhD students Steph who has presented at her first *proper* national conference - showcasing her work on the #NKcell regulation of T cells in #liver cancer.

Well done Steph!

Glutamine sensing licenses cholesterol synthesis | The EMBO Journal imageimageWhether cholesterol biosynthesis can be adjusted to the availability of input carbon sources remains unclear. This study demonstrates that glutamine is directly sensed by and required for ac...

“Glutamine sensing licenses cholesterol synthesis”

#glutamine interacts with SCAP to alter the ER to Golgi trafficking needed to activate #SREBP transcriptional response.

www.embopress.org/doi/full/10....

Is this relevant to #immunometabolism, such as SREBP-dependent #NKcell responses?

3/3 #NKcell recovery @ day 30 strongly predicts better OS & PFS. One-log increase in NK count was associated with 36% ⬇️ in mortality risk. CD4 Tcell & B cell recovery were not linked to OS/PFS. Inflammatory cytokines and biomarkers were inversely related to NK cell recovery #CARTcells

Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity Targeting TIM-3 palmitoylation mediated by DHHC9 enhances CAR-T cell– and NK cell–based tumor immunotherapy by suppressing immune exhaustion.

In #ScienceImmunology last week, Zhang & al reported that the stability & expression of #ImmuneCheckpoint molecule #TIM3 is regulated by palmitoyltransferase DHHC9. Peptidic inhibitor of DHHC9 accelerates TIM-3 degradation & enhances #CARTCell & #NKCell #antitumor immunity!

bit.ly/SI_adp7302

Representative CD20 staining of spleen and mandibular lymph node sections from animals treated with vehicle or CD20-NKCE-IL2v (0.5 mg/kg). Scale bars: 3 mm

This week in #ScienceImmunology: Olivier Demaria, Eric Vivier, & al. use tetraspecific #NKCell engager (comprising an anti- #NKp46 Ab fragment + #IgG1 #Fc fragment + #IL2 variant + anti- #CD20 Ab) to target #BCell -specific #NonHodgkin #lymphoma (B-NHL) in mouse & NHP models!

bit.ly/SI_adp3720