📚MedChemExpress Digest | Targeting #Lipid #Metabolism in #Cancer
🔬Cancer cells reprogram lipid uptake, synthesis & oxidation to fuel growth, survive stress & evade immunity. These pathways (#CD36, #FASN, #ACLY, #ACC, #SREBP) offers promising anticancer strategies. 👉Discover more: ow.ly/8RmS50XgbgE

Therapeutic strategies targeting SREBP transcription factors: an update to 2024 In addition to regulating lipid biosynthesis and uptake, sterol regulatory element binding protein (SREBP) is involved in mediating biological signaling networks.

'Therapeutic strategies targeting SREBP transcription factors: an update to 2024' - an @amm-journal.org review article on #ScienceOpen:

🔗 www.scienceopen.com/hosted-docum...

🖇️ #Pharmacology #SREBP #LipidMetabolism #TherapeuticTargets

SREBP: clave central en la regulación del metabolismo de lípidos y su implicación en enfermedades Investigadores han consolidado a las proteínas SREBP como reguladoras maestras del metabolismo de lípidos, fundamentales para el control de la síntesis de colesterol, ácidos grasos y triglicéridos.

SREBP: clave central en la regulación del metabolismo de lípidos y su implicación en enfermedades killbait.com/es/srebp-cla... #ciencia #srebp #metabolismo #lípidos

Glutamine sensing licenses cholesterol synthesis | The EMBO Journal imageimageWhether cholesterol biosynthesis can be adjusted to the availability of input carbon sources remains unclear. This study demonstrates that glutamine is directly sensed by and required for ac...

“Glutamine sensing licenses cholesterol synthesis”

#glutamine interacts with SCAP to alter the ER to Golgi trafficking needed to activate #SREBP transcriptional response.

www.embopress.org/doi/full/10....

Is this relevant to #immunometabolism, such as SREBP-dependent #NKcell responses?