RESEARCH COMMUNICATION: A brain-specific microRNA, miR-1000, regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster
By Verma et al. and David Van Vactor
➡️ https://genesdev.cshlp.org/content/40/7-8/444.full

Harvard Medical School
#Drosophila #lipidmetabolism #miRNA

This review highlights #Neuregulin4 as a versatile regulator of #inflammation and tissue homeostasis, improving #LipidMetabolism, #InsulinSensitivity, and liver health, while emphasizing its complex involvement in #cancer & metabolic diseases.
#OpenAccess: doi.org/10.1016/j.ge...

#PRKAR2B emerges as a key #biomarker in capsular contracture, linking #LipidMetabolism and immune cell infiltration, where reduced expression is associated with severe #fibrosis, highlighting its potential role in diagnosis and disease progression.
#OpenAccess: doi.org/10.1016/j.ge...

U01.01.090 Rate-determining enzymes of metabolic processes A comprehensive review of U01.01.090 Metabolic Pathways. Identify the "bottleneck" enzymes of carbohydrate, lipid, and nucleotide metabolism and the allosteric effectors that control fuel storage versus mobilization.

🚦 The Metabolic Traffic Lights: Master the Rate-Limiting Steps! 🚦
#USMLEStep1 #MedEd #Biochemistry #Metabolism #Enzymes #Step1Prep #HighYield #MedSchool #Endocrinology #Glycolysis #LipidMetabolism #Statins #FutureDoctor #StudyGram

U01.01.069 Essential fatty acids Test your knowledge of U01.01.069 Essential Fatty Acids. Practice identifying the structures of Linoleic and α-Linolenic acid, their metabolic derivatives, and the clinical signs of lipid deficiency with this expert-curated MCQ set.

🐟 The Building Blocks of Health: Mastering Essential Fatty Acids! 🐟
#USMLEStep1 #MedEd #MedicalStudent #Biochemistry #Nutrition #Step1Prep #HighYield #MedSchool #LipidMetabolism #Omega3 #Omega6 #HealthyFats #USMLE #FutureDoctor #StudyGram #MedTwitter

🚀From Bench to Paper | New work in EClinicalMedicine: a circulating three-lipid signature (3LS)—previously identified as a poor prognostic #biomarker in metastatic castration-resistant #ProstateCancer (#mCRPC), actively contributes to disease progression.
#LipidMetabolism #CancerResearch

Grateful to all our amazing co-authors for making this work possible!

#CellBiology #celegans #NuclearEnvelope #LipidMetabolism #OpenScience

An overview of #LipidMetabolism in #Homeostasis & disease, highlighting how lipid signaling reprograms #ImmuneCells and exploring innovative therapeutic strategies for #Cancer, #CardiovascularDisease, and metabolic disorders.

#OpenAccess: doi.org/10.1038/s413...

Synapse: Your Connection to our MSK Authors
Meet: Tobias Christian Walther
Research Focus: Cell Biology; Non-Stipend Program Chair

DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function

synapse.mskcc.org/synapse/work...
#DGAT #LipidMetabolism #Thermogenesis

This review highlights #LipidMetabolism in #ImmuneCells, showing how #LipidPathways regulate proliferation, differentiation, and activation, their roles in #cancer, #autoimmune, and metabolic diseases, and emerging therapies and #biomarkers.

#STTT: doi.org/10.1038/s413...

Male in tye dye shirt smiline with beard and a heart sign made with his hands over his chest. . Study 1. Malkin CJ, Pugh PJ, Morris PD, Kerry KE, Jones RD, Jones TH, Channer KS. Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life. Heart. 2004;90:871–876. . image: freepik.com

TRT timeline: Early metabolic changes occur sooner than many expect.

📊 Reductions in serum total cholesterol have been observed within ~4 weeks in clinical studies, suggesting early improvements in lipid metabolism alongside hormonal optimization. [1]

#TRT #LipidMetabolism #EvidenceBasedCare

🚨 New collaborative paper out on lipid metabolism in MASLD, starting from MAPK15. A nice example of how signaling pathways intersect with metabolic regulation. It was a pleasure to contribute and be involved. #MASLD #LipidMetabolism #MAPK15 #TBT #TBlab

journals.lww.com/hepcomm/full...

A comprehensive review of how lipid metabolism shapes osteoporosis, from clinical implications to cellular mechanisms.
#LipidMetabolism #Osteoporosis #BoneMetabolism #Adipogenesis #BoneHealth #MetabolicDisease
www.sciencedirect.com/science/arti...

Impact of peroxisomal biogenesis protein PEX11a deficiency on cardiomyocyte structure and cardiac function in a mouse model. #cardiomyocyte #peroxisome #ischemia #oxidativestress #lipidmetabolism #MALDIMSI
www.mdpi.com/2073-4409/15...

#Review #ccRenalCellCarcinoma #mRCC
#kidneys #lipids #membranes #lipidmetabolism #dehydration #protein
Salt levels to be considered. #metals #microelements

In November's #EditorsChoice, Katerina Yamamoto, @cswormlab.bsky.social & co investigate the connection between #InnateImmunity and #LipidMetabolism, using the worm model #Celegans

⚡ doi.org/10.1242/dmm....
📰https://doi.org/10.1242/dmm.052357

Integrating #Transcriptomics & #Metabolomics, this study analyzed the phase-specific characteristic signaling & metabolism changes in hepatic IRI, revealing the critical role of #LipidMetabolism in its progression.

#OpenAccess: doi.org/10.1016/j.ge...

Deciphering the active site: Why motif conservation in Pah1 matters for yeast lipid homeostasis The enzyme Pah1 is a central figure in the lipid metabolism of Saccharomyces cerevisiae, acting as a Mg2+-dependent phosphatidate (PA) phosphatase that converts PA into diacylglycerol. This catalytic ...

Using sequence alignment and AlphaFold modeling, the Carman lab at Rutgers identified four conserved motifs in yeast Pah1 essential for catalytic activity and lipid balance. go.njmicrobe.org/lmCbZg #Microbiology #YeastResearch #LipidMetabolism #Pah1 #AlphaFold #Lipin #MajeedSyndrome #Rhabdomyolysis

Katerina Yamamoto, Cathy Savage-Dunn & co report that BMP-dependent #LipidMetabolism not only regulates classical aspects of #InnateImmunity, but potentially also promotes resilience against microbial pathogens.

@cswormlab.bsky.social

Read here journals.biologists.com/dmm/article/...

This month's Editor's Choice highlights an article on the connection between #InnateImmunity and #LipidMetabolism, investigated using the worm model #Celegans

Read the short, simple retelling here journals.biologists.com/dmm/article/...
More details in the thread.

@cswormlab.bsky.social

a cartoon drawing of a brain with arms and legs Alt: a cartoon drawing of a brain with arms and legs

Heading to my FIRST #sfn2025 come catch up and check out my posters on Saturday C25 PSTR009.17, C10 PSTR0009.02 and Early Career session B44 for all things #astrocytereactivity #whitematter #lipidmetabolism and #microglia

U01.01.124 Key enzymes in lipid transport Analyze the mechanism of action described in the question stem. Focus on how the drug inhibits degradation of LDL receptors and thereby enhances LDL receptor recycling. Determine which enzyme normally promotes LDL receptor breakdown. Match this with your knowledge of lipid metabolism pathways to select the correct answer.

Master the enzymes that drive lipid transport and metabolism. #Biochemistry #USMLE #LipidMetabolism #MedicalEducation #Cholesterol

New research reveals that 8-Cl-Ado inhibits #Hepatocarcinogenesis by suppressing #ADAR1 and regulating PPARγ-driven #LipidMetabolism, offering new #therapeutic targets for #HCC. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

3D reconstructions of local synaptic connectivity in hippocampal CA1 pyramidal neurons obtained by volume electron microscopy. Dendritic segments (gray) are shown either alone or with their innervating axons in a wild-type mouse (left) and in a Cyfip2+/R87C knock-in mouse model of West syndrome (right). Yellow puncta indicate postsynaptic densities. Compared with wild-type neurons, knock-in neurons exhibit markedly reduced dendritic spines, with excitatory synapses forming directly on dendritic shafts and showing dense clustering of presynaptic axon terminals. Scale bar, 1 µm. Image credit: Kea Joo Lee and Gyu Hyun Kim.

#WestSyndrome is a severe neurodevelopmental disorder. This study provides a longitudinal picture of glial activation, synaptic remodeling & #LipidMetabolism in a mouse model of West syndrome, uncovering cellular & molecular mechanisms linked to #seizure evolution @plosbiology.org 🧪 plos.io/48tgUkv

3D reconstructions of local synaptic connectivity in hippocampal CA1 pyramidal neurons obtained by volume electron microscopy. Dendritic segments (gray) are shown either alone or with their innervating axons in a wild-type mouse (left) and in a Cyfip2+/R87C knock-in mouse model of West syndrome (right). Yellow puncta indicate postsynaptic densities. Compared with wild-type neurons, knock-in neurons exhibit markedly reduced dendritic spines, with excitatory synapses forming directly on dendritic shafts and showing dense clustering of presynaptic axon terminals. Scale bar, 1 µm. Image credit: Kea Joo Lee and Gyu Hyun Kim.

#WestSyndrome is a severe neurodevelopmental disorder. This study provides a longitudinal picture of glial activation, synaptic remodeling & #LipidMetabolism in a mouse model of West syndrome, uncovering cellular & molecular mechanisms linked to #seizure evolution @plosbiology.org 🧪 plos.io/48tgUkv

3D reconstructions of local synaptic connectivity in hippocampal CA1 pyramidal neurons obtained by volume electron microscopy. Dendritic segments (gray) are shown either alone or with their innervating axons in a wild-type mouse (left) and in a Cyfip2+/R87C knock-in mouse model of West syndrome (right). Yellow puncta indicate postsynaptic densities. Compared with wild-type neurons, knock-in neurons exhibit markedly reduced dendritic spines, with excitatory synapses forming directly on dendritic shafts and showing dense clustering of presynaptic axon terminals. Scale bar, 1 µm. Image credit: Kea Joo Lee and Gyu Hyun Kim.

#WestSyndrome is a severe neurodevelopmental disorder. This study provides a longitudinal picture of glial activation, synaptic remodeling & #LipidMetabolism in a mouse model of West syndrome, uncovering cellular & molecular mechanisms linked to #seizure evolution @plosbiology.org 🧪 plos.io/48tgUkv

This study reveals that CSC-derived EVs deliver #lncRNA ROLLCSC to #LUAD cells by reshaping #LipidMetabolism & boosting #Ferroptosis resistance. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

🦠 Intrabacterial lipid inclusion-associated proteins: a core machinery conserved from saprophyte Actinobacteria to the human pathogen Mycobacterium tuberculosis

🔓https://buff.ly/fI7675n

@canaanlab.bsky.social @lkremer1.bsky.social @pierresantucci.bsky.social

#LipidMetabolism #Mycobacterium

Reciprocal regulation between fibrinolysis and lipid metabolism Sept. 17, 2025 | 12:15 p.m. Eastern

Save the date for our next #ASBMBBreakthroughs webinar, "Reciprocal regulation between fibrinolysis and lipid metabolism."

Details ⬇️ ⬇️ ⬇️

Sept. 17 | 12:15 p.m. EDT

Ze Zheng of @versitiresearch.bsky.social will present her research on lipid metabolism.
ow.ly/beH950WOson
#Lipids #LipidMetabolism

Mitochondrial Dysfunction as a Therapeutic Target in Diabetic Cardiomyopathy: Progress and Prospects This review highlights new targets and drugs to address mitochondrial dysfunction in diabetic cardiomyopathy (DCM) and slow its progression.

This review outlines strategies to enhance mitochondrial function, such as regulating biogenesis, promoting #mitophagy, using antioxidants, modulating the calcium balance, & optimizing #LipidMetabolism, providing new insights for #DiabeticCardiomyopathy treatment.

#OpenAccess: tinyurl.com/29a62mqs