Top: Micrographs of Anabaena filaments of WT, ΔcdgSpICT-all1219 strains (left), and Δ8DGC-1 strain (right) cultured in BG11 medium with (+) or without (−) Cu2+ and theophylline at the indicated time points. Scale bars represent 15 µm. Bottom: Schematic of the proposed dual-threshold c-di-GMP regulatory system that governs cell growth and survival in Anabaena.
Cyclic‑di‑GMP regulates diverse #bacterial functions, but what #enzymes coordinate its homeostasis? This study shows that the 16 enzymes involved in #c-di-GMP turnover in #Anabaena function as an electromechanical-like dual relay to control #CellSize & viability @plosbiology.org 🧪 plos.io/3QubUVG