This review highlights #NLRP3 as a key driver of #DiabeticCardiomyopathy, integrating #MetabolicStress to fuel inflammation, #pyroptosis & #fibrosis, and proposes strategies to target NLRP3 to break the metabolism–inflammation cycle.

#OpenAccess: doi.org/10.1016/j.ge...

Jianpi Qinghua Formula Alleviates Diabetic Myocardial Injury Through Inhibiting JunB/c-Fos Expression

The Jianpi Qinghua formula alleviates #DiabeticCardiomyopathy by reducing #myocardial #apoptosis and inflammation while improving #cardiac structure and function, underscoring its therapeutic potential in #diabetes‑related #HeartInjury. @ShanghaiUni_TCM
Read: doi.org/10.1007/s115...

#DiabeticCardiomyopathy #FGF9

FGF9⬇️in db/db 🐭🫀

AAV9-cTnt-FGF9 in db/db🐭
⏫🫀function LVEF LVFS
⏬Myocyte hypertrophy
⏬Myocyte lipid droplet
⏬Interstitial fibrosis
Abrogated by AMPKα2 T172A (domi neg)

FGF9-autophagy-p62-KEAP1-NRF2 cardioprotective axis

#CommsBio 2025
www.nature.com/articles/s42...

MicroRNAs Have an Immunomodulatory Role in Diabetes Mellitus and Diabetic Cardiomyopathy miRNAs play a key role in immune regulation in diabetic cardiomyopathy, offering potential therapeutic targets for improved treatment strategies.

This #CVIA review provides an overview of the #Epidemiology & #Pathology of #DiabeticCardiomyopathy (DCM) with insights into the complex interactions between #miRNAs & immune pathways in DCM, highlighting the potential of miRNA-based interventions in DCM management. #OpenAccess: tinyurl.com/2c9gy4dw

#Medsky🧪 #IDsky #Cardiosky #immunosky #publichealth Pre-existing #diabeticcardiomyopathy (DCM) & #COVID share several pathogenic mechanisms, creating an intersecting relationship that significantly amplifies 🫀 risks.

The heart of diabetes: unraveling metabolic drivers of cardiomyopathy Diabetic cardiomyopathy is a distinct complication of diabetes, propelled by metabolic remodelling of the myocardium. Understand the complex interplay driving this change and explore the emerging…

#DiabeticCardiomyopathy is a distinct complication of #diabetes, propelled by metabolic remodeling of the myocardium.

Understand the complex interplay driving this change and explore the emerging therapies that could mitigate it.

👉https://buff.ly/c4OnrCe

#CardioSky

Mitochondrial Dysfunction as a Therapeutic Target in Diabetic Cardiomyopathy: Progress and Prospects This review highlights new targets and drugs to address mitochondrial dysfunction in diabetic cardiomyopathy (DCM) and slow its progression.

This review outlines strategies to enhance mitochondrial function, such as regulating biogenesis, promoting #mitophagy, using antioxidants, modulating the calcium balance, & optimizing #LipidMetabolism, providing new insights for #DiabeticCardiomyopathy treatment.

#OpenAccess: tinyurl.com/29a62mqs

MicroRNAs Have an Immunomodulatory Role in Diabetes Mellitus and Diabetic Cardiomyopathy miRNAs play a key role in immune regulation in diabetic cardiomyopathy, offering potential therapeutic targets for improved treatment strategies.

miRNAs play a key role in immune regulation in diabetic cardiomyopathy, offering potential therapeutic targets for improved treatment strategies.

Read More: cvia-journal.org/diabetic-car...

#diabeticcardiomyopathy #diabetesmellitus #Immune #inflammation #CVIAJournal #cardiology #CardioEd