Antonysunil Adaikalakoteswari presented at #SFEBES2026 on how maternal vitamin #B12 deficiency affects #placental development. Using #multiomics data from the #PRiDE cohort, the study found changes in #DNAmethylation, gene expression and #miRNAs linked to low B12.
@socendocrinology.bsky.social

Exploring Biomarkers for Early Diagnosis of Abdominal Aortic Aneurysms Exploring the circulating biomarkers for abdominal aortic aneurysm (AAA), emphasizing its potential prognostic and diagnostic abilities.

This review explores different circulating molecules related to #Inflammation and ECM degradation, regulatory #miRNAs, metabolites, and cellular and vesicular entities as #Biomarkers for AAA, highlighting their prognostic and diagnostic potential.

#OpenAccess: cvia-journal.org/circulating-...

New year and new opportunities! There is an open call for a PhD student to join our lab.
#RNA biology #circRNAs #miRNAs #neuroscience #neuroedocrinology

Please share with potential candidates 🙏🫶.
A link to the call & more details here: www.phdscanner.com/opportunitie...

Representative confocal images of a control testis (top row), a testis somatically depleted of chinmo (middle row), and a testis with somatic co-depletion of chinmo and zld (bottom row). Testes are stained for Vasa (gray), Fas3 (green, grayscale), and Tj (magenta).

How is somatic gonadal #sex fate maintained throughout adulthood? This study identifies a post-transcriptional mechanism involving repression of the TF Zelda by #miRNAs, safeguarding male identity & preventing activation of the female program in #Drosophila #testis @plosbiology.org 🧪 plos.io/4pMT6hq

Representative confocal images of a control testis (top row), a testis somatically depleted of chinmo (middle row), and a testis with somatic co-depletion of chinmo and zld (bottom row). Testes are stained for Vasa (gray), Fas3 (green, grayscale), and Tj (magenta).

How is somatic gonadal #sex fate maintained throughout adulthood? This study identifies a post-transcriptional mechanism involving repression of the TF Zelda by #miRNAs, safeguarding male identity & preventing activation of the female program in #Drosophila #testis @plosbiology.org 🧪 plos.io/4pMT6hq

Representative confocal images of a control testis (top row), a testis somatically depleted of chinmo (middle row), and a testis with somatic co-depletion of chinmo and zld (bottom row). Testes are stained for Vasa (gray), Fas3 (green, grayscale), and Tj (magenta).

How is somatic gonadal #sex fate maintained throughout adulthood? This study identifies a post-transcriptional mechanism involving repression of the TF Zelda by #miRNAs, safeguarding male identity & preventing activation of the female program in #Drosophila #testis @plosbiology.org 🧪 plos.io/4pMT6hq

Join us on Friday for @uam-ibmib.bsky.social IBMiB seminar of Halina Petrykowska from our Department of Gene Expression to learn about male-specific #miRNAs whihc regulate sperm development and function in Marchantia polymorpha!

MicroRNAs Have an Immunomodulatory Role in Diabetes Mellitus and Diabetic Cardiomyopathy miRNAs play a key role in immune regulation in diabetic cardiomyopathy, offering potential therapeutic targets for improved treatment strategies.

This #CVIA review provides an overview of the #Epidemiology & #Pathology of #DiabeticCardiomyopathy (DCM) with insights into the complex interactions between #miRNAs & immune pathways in DCM, highlighting the potential of miRNA-based interventions in DCM management. #OpenAccess: tinyurl.com/2c9gy4dw

This review highlights how #miRNAs regulate #AdiposeTissueFibrosis and how #Secretomes from miRNA-transfected stem cells contribute to combating #FibroticDiseases. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

For #LiverAwarenessMonth, let's take a look at a study that found adipose tissue macrophage-derived sEVs promote liver fibrosis in obesity via pro-fibrogenic miRNAs.
Read it here: 🔗 ow.ly/Wx9550XcMkB
#LiverFibrosis #MASH #sEVs #miRNAs

Here’s a visual overview of #microRNA biogenesis 👇
From #transcription to maturation, #miRNAs are processed through #canonical and #non-canonical pathways, loaded into #RISC complexes, and regulate #gene expression by translation #inhibition or mRNA #degradation
#MolecularBiology #Neurobiology

Early #diagnosis is key in #neurodegenerative #diseases — and #miRNAs could make it possible.
Learn how they’re reshaping #biomarker discovery and #therapy design 🧬👇
🔗 rdcu.be/eJJJ3
#Alzheimers #Parkinsons #ALS #Huntingtons #miRNA #Neurobiology

Researchers from Gansu Agricultural University report a new study published in Horticulture Research. The team performed genome-wide profiling of small RNAs and degradome sequencing to investigate potato dormancy release.
#miRNAs #Tuber dormancy
Details: doi.org/10.1093/hr/u...

Schematic overview of our project. Dissection of Xenopus neural crest following morpholino knockdown of miRNA, then extraction of RNA for RNA-seq

Our new paper is out in Dev Biol! 🎉 🐸🧬
We show #miR-196a directs #neural crest fate in #Xenopus by repressing immature neural #ectoderm — evidence #miRNAs can potentially drive, not just fine-tune, early patterning
👉 Read more here: doi.org/10.1016/j.yd...
@devbiol.bsky.social @biouea.bsky.social

Excited to share our new preprint: Local Non-Coding Regulatory Elements in the Muscular Dystrophies 🚀
We review how #lncRNAs, #miRNAs, and epigenetic regulators shape disease mechanisms in #DMD, #FSHD, #LGMD & more. www.preprints.org/manuscript/2... #preprints via @Preprints_org

#miRNAs as an bio marker for understanding the molecular mechanisms of #longCOVID, developing innovative diagnostic tools, and exploring potential therapeutic interventions.

Numerous studies have demonstrated the role of #miRNAs in modulating immune responses & inflammation, which are 🔑 characteristics of LC.
- Dysregulated miRNAs, particularly miR-146a & miR-155, which control ACE2 expression & inflammatory mediators,

The relationship between microRNAs and COVID-19 complications Over the past three years, since the onset of COVID-19, several scientific studies have concentrated on understanding susceptibility to the virus, the…

Studies have revealed altered miRNA profiles in LC patients, with specific #miRNAs implicated in immune responses, inflammation, and tissue repair
www.mdpi.com/1422-0067/25...

www.sciencedirect.com/science/arti...

academic.oup.com/jleukbio/art...

pmc.ncbi.nlm.nih.gov/articles/PMC...

Drs Paola Pepe, Elena Ciccone, Nunzio Antonio Cacciola, Chiara Bazzocchi & Laura Rinaldi review the potential of #miRNAs in #cystic #echinococcosis. #Echinococcus #granulosus #Biomarker

authors.elsevier.com/a/1lRGZ5Eb1x...

Our July issue is online now! 🌞
Featuring a Review on how #miRNAs coordinate #metabolism and #immune responses, and research into #Brucella pathogenesis, zinc binding of TLRs, insights into how the multispecific antibody G2 binds to different peptides, and more.

Online here➡️ tinyurl.com/ux99jr7j

Diagram of a water tank, representing the rapid turnover of miRNA repertoire. A tap opening into the top of the tank represents miRNA gain and a drain pipe at the bottom of the tank represents miRNA loss.

We've got your ticket for summer blockbuster season!

First up: "Fast and furious: The rapid turnover of microRNAs in plants." Explore the evolutionary & biological significance of #plant #miRNAs with Guo et al. in this 🔓 #review!
doi.org/10.1111/jse....
#PlantScience #evolution #FreeAccess

A comprehensive discussion on the #HippoSignaling pathway, its key components, and its relevance in #BreastCancer, with insights on its regulation by #miRNAs and other related pathways. #medsky

#OpenAccess:

#microRNAs #miRNAs #RISC #EMT #regulation #transcriptome

Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding

👉 buff.ly/0JDAqlG

#AGO2 #miRNAs #RBCs

Causal role of MiRNAs in chronic rhinosinusitis: mendelian randomization and validation study - Allergy, Asthma & Clinical Immunology Background Despite significant advances in understanding the epigenetic landscape of chronic rhinosinusitis (CRS), the specific microRNAs (miRNAs) with a causal role in CRS pathogenesis remain unclear...

Study identifies causal #miRNAs as potential biomarkers for #CRS, with risk-increasing miRNAs linked to autophagy and MAPK pathways, a protective miRNA tied to apoptosis and PI3K-AKT signaling, advancing CRS understanding and offering novel diagnostic/therapeutic avenues.
🔗 ino.to/0ksLmmA
#ImmunoSky

MicroRNAs in adipose tissue fibrosis: Mechanisms and therapeutic potential

This review discusses the role and mechanisms of various #miRNAs in promoting #AdiposeTissueFibrosis & explores the mechanisms and advantages of miRNA-transfected adipose-derived stem cells #secretome in mitigating adipose tissue fibrosis. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

MicroRNAs unveiled: Nobel recognition of a revolutionary gene regulation mechanism
doi.org/10.1016/j.hl...
#MicroRNAs #miRNAs #academics #AcademicChatter #AcademicTwitter

A panel of #miRNAs in the serum extracellular vesicles serve as novel diagnostic biomarkers for MASLD

www.sciencedirect.com/science/arti... #OpenAcess #liver #MedSky

Check out this paper from Busato et al, showing a first-of-its-kind analysis of 6 #miRNAs simultaneously by Silla #dPCR. A combination of miRNA-specific stem-loop primers and dPCR with hydrolysis probes produced linear and reproducible quantification results: www.sciencedirect.com/science/arti...

🧠 Recent investigation underscores the potential of non-pharmacological treatments in #psychiatry such as #exosomes, #miRNAs, #stemcell, #mitochondria transfer, #exercise therapy, or #transcranial stimulation.
📌↘️

@altmetric.com

@cambridgeup.bsky.social