Comprehensive Physiology | Review Spotlight 🔦 Deciphering the Molecular Dialogue: #Mitochondria, #Epigenetics, and Extracellular Vesicles in #Placental Function and #Pregnancy Complications by Yu-Chin Lien and Rebecca A. Simmons. Read more:
https://ow.ly/EkF550YCuii
#BAP1 overexpression induces early onset #preeclampsia–like features in #placental #organoids: ❌blocked extravillous #trophoblast differentiation
❌impaired syncytialization
🔥persistent pro-inflammatory signatures @cbm-csic-uam.bsky.social @csic.es 👏🥳team! www.nature.com/articles/s41...
A recent study by Veronica B. Bothaand colleagues investigates #placental iron utilisation in fetal growth restriction, examining alterations in mitochondrial haem synthesis and iron–sulphur cluster assembly pathways 🔬 🔃
📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Rui Zhou and colleagues observed that methionine adenosyl-transferase 2A promotes #placental angiogenesis by regulating VEGF-A translation via the mTORC1 #signalling pathway 🔬🚦
📜 Read the #Research here:
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Antonysunil Adaikalakoteswari presented at #SFEBES2026 on how maternal vitamin #B12 deficiency affects #placental development. Using #multiomics data from the #PRiDE cohort, the study found changes in #DNAmethylation, gene expression and #miRNAs linked to low B12.
@socendocrinology.bsky.social
📢 Check out this new study from the lab of Dr. Alison Paquette (@alisonpaquette.bsky.social) at Seattle Children’s Research Institute!
It shows that the placental transcriptome serves as a mechanistic link between prenatal #phthalate exposure and #placental efficiency.
🔗 https://bit.ly/4rFwgcV
🚨Preprint! #Placental #organoids developing #preeclampsia (PE)?🤯Boosting #BAP1 induced key traits of early-onset PE:
❌impaired syncytialization & EVT differentiation
🔥persistent pro-inflammatory signals
🤒broad placental dysfunction
🚀🥦🎉team!
@cbm-csic-uam.bsky.social
www.biorxiv.org/content/10.1...
The four P's: #preeclampsia puerperal #sepsis #placental and uterine complications and #peripartum #cardiomyopathy
#Research by India A. Brooker et al. observed that angiotensin-converting enzyme 2 regulates the #placental response to repeated #hypoxia–reoxygenation insult 💉 🧪
📜 Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Recent research investigated if there were #sexdifferences in the response of the #placental transcriptome to #maternal #foodrestriction, and found that while there were few interactions between sex and food restriction, the sex-stratified analyses yielded several of ‘sex-specific’ effects
Das gilt übrigens auch für diejenigen die #Covid für einen Witz halten ... Warum?
Nun unsere #Luftqualität hat definitif nichts mehr mit der #Atemluft aus Jurassic Park zu tun
Hier: #Urban #air #pollution disrupts #placental microarchitecture ...
www.sciencedirect.com/science/arti...
🚀 We are hiring!
Prof Felicia Basilicata joined us and is currently offering:
🔹 #PhD #position in #Neurodevelopmental #Disorders
🔹 PhD position in Human X #Chromosome #Regulation
🔹 #MSc #Thesis in #Placental #Cell #Biology Regulation
🔹 Lab #Assistant (BTA / MTA )
www.med.lmu.de/bmc/en/jobs-...
Overall, we show that #placental #epigenetics may further our understanding of the association between #IVF and negative pregnancy outcomes, and that sex-specific differences in #DNAmethylation and cell composition should be considered when analyzing placental data.
We estimated #placental cell composition for each sample using cell type specific #DNAmethylation patterns, and found that there were differences between fetal sex and between conception type in main placental cell type proportions.
Very excited to share the results from our latest Meta-analysis at the Wilson Pregnancy Lab examining #placental DNA methylation in #IVF pregnancies doi.org/10.1093/mole...
@smithk63.bsky.social @samanthalwilson.bsky.social
@oxfordacademic.bsky.social
Three-dimensional confocal image of a swine trophoblast organoid immunostained for ZO-1 (green) and actin (purple), with nuclei counterstained using DAPI (grey). ZO-1 highlights tight junctions at the apical borders in the center of the organoids, while actin outlines cellular architecture, revealing organized epithelial polarity within the organoid structure. Image credit: Cole McCutcheon, Duke University.
In vitro model of porcine placental development: @crm110.bsky.social &co develop a swine trophoblast #organoid model that mimics in vivo #trophoblast diversity & gene expression, providing a platform for studying #placental biology & #MaternalFetalInteractions @plosbiology.org 🧪 plos.io/47jf3yd
#Placental transfer of #medications to treat #COVID19, #molnupiravir, #favipiravir and #nirmatrelvir/ritonavir, in the ex vivo human cotyledon model, etidiohnew.blogspot.com/2025/09/plac...
Three-dimensional confocal image of a swine trophoblast organoid immunostained for ZO-1 (green) and actin (purple), with nuclei counterstained using DAPI (grey). ZO-1 highlights tight junctions at the apical borders in the center of the organoids, while actin outlines cellular architecture, revealing organized epithelial polarity within the organoid structure. Image credit: Cole McCutcheon, Duke University.
In vitro model of porcine placental development: @crm110.bsky.social &co develop a swine trophoblast #organoid model that mimics in vivo #trophoblast diversity & gene expression, providing a platform for studying #placental biology & #MaternalFetalInteractions @plosbiology.org 🧪 plos.io/47jf3yd
Three-dimensional confocal image of a swine trophoblast organoid immunostained for ZO-1 (green) and actin (purple), with nuclei counterstained using DAPI (grey). ZO-1 highlights tight junctions at the apical borders in the center of the organoids, while actin outlines cellular architecture, revealing organized epithelial polarity within the organoid structure. Image credit: Cole McCutcheon, Duke University.
In vitro model of porcine placental development: @crm110.bsky.social &co develop a swine trophoblast #organoid model that mimics in vivo #trophoblast diversity & gene expression, providing a platform for studying #placental biology & #MaternalFetalInteractions @plosbiology.org 🧪 plos.io/47jf3yd
#Placental expulsion occurred when the placenta came out of the birth canal after childbirth. The time between the expulsion of the baby and the expulsion of the placenta was called the third stage of labor.
Don’t miss this interesting article on #placental DNA methylation.
“Profiling (placental) #DNAmethylation in cell-free DNA across #gestation: the Rotterdam Periconception Cohort”
Free to read 🔗📚
academic.oup.com/molehr/artic...
A recent study suggests potential causal relationship btw fetal genetically predicted ⬆️ #placental weight & ⬇️ risk of #migraine in that offspring, providing insights into potential influence of #prenatal factors on migraine risk
headachejournal.onlinelibrary.wiley.com/share/7W3KIT...
C-C Liao et al
This study by Grace J. Hattersley of cambridge-scm.bsky.social et al. examines the impact of #metformin on #placental ageing in humans and mice 🔍 💊
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Spatial single-cell analysis identifies #placental villi structural and immune remodeling across #gestation from @konnikovalab.bsky.social
www.mucosalimmunology.org/article/S193...
Researchers JParchem, RKeuls, RParchem et al were in the right place at the right time and uncovered key #placental responses to #COVID19. #AJOG_thegray #maternalFetalBarrier @bcmhouston.bsky.social #BCMGradSchool #BCMCancerCenter #preeclampsia #McGovernMed blogs.bcm.edu/2025/04/29/f...
A slide from an immune research discussion at NIAID on April 1, 2025. The research is from the Human Immunology Project. This slide is about maternal immunity and placental sampling. Some info will be archived at https://immunespace.org
Our annual mtg begins today with @edlow.bsky.social
discussing #placental #immune cells + potential links to #pregnancy complications.
Each of 8 centers share during our 2-day mtg.
Later, we will hear from Boris Juelg + Douglas Lauffenberger.
(both part of maternal omics project)
The Role of #VitaminD Deficiency in #Placental Dysfunction: A Systematic Review
Findings from human studies indicate that maternal vitamin D deficiency significantly impairs placental function by reducing vascular integrity, downregulating nutrient transporters, and promoting #inflammation.
In our January issue: #Placental #malaria & #circumsporozoite protein-specific #immunity, authored by Lars Hviid, Nicaise Tuikue Ndam & Stephen J. Rogerson. #CSP #VAR2CSA #Vaccination @upcite.bsky.social @ird-fr.bsky.social @thedohertyinst.bsky.social
www.cell.com/trends/paras...
placental
- Pertaining to or having or occurring by means of a placenta
Learn More...
#definition #placental #meaning #english #ielts
