BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia Preeclampsia, a life-threatening hypertensive disorder of pregnancy, is a leading cause of maternal and perinatal morbidity and mortality. Its early-onset form (EO-PE), requiring delivery before 34 we...

🚨Preprint! #Placental #organoids developing #preeclampsia (PE)?🤯Boosting #BAP1 induced key traits of early-onset PE:
❌impaired syncytialization & EVT differentiation
🔥persistent pro-inflammatory signals
🤒broad placental dysfunction
🚀🥦🎉team!
@cbm-csic-uam.bsky.social
www.biorxiv.org/content/10.1...

A Photograph of Dr. Samuel Peña-Llopis & Dr. Silvia Vega-Rubin-de-Celis

Researchers at University Hospital Essen have uncovered that #Autophagy suppression via #SRC induction represents a therapeutic vulnerability for #BAP1 -mutant cancers.
Read more: www.tandfonline.com/doi/full/10....

May is #SkinCancerAwarenessMonth! Pathogenic variants in #CDKN2A #BAP1 #POT1 & #CDK4 are associated with increased #melanoma risk. #GorlinSyndrome, caused by pathogenic variants in #PTCH1, is associated with increased #basalcellcarcinoma risk. Learn more👇
www.cancer.gov/types/skin/h...

May is #SkinCancerAwarenessMonth! Pathogenic variants in #CDKN2A #BAP1 #POT1 & #CDK4 are associated with increased #melanoma risk. #GorlinSyndrome, caused by pathogenic variants in #PTCH1, is associated with increased #basalcellcarcinoma risk. Learn more👇
www.cancer.gov/types/skin/h...