Inducible POU2F3 expression in human intestinal organoids as a model of human tuft cells All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.

Interested in studying #humanTuftCells? C. Bomidi, S. Blutt, M. Estes et al found a way using human intestinal #organoids. @bcmhouston.bsky.social www.sciencedirect.com/science/arti...

Using retinal organoids, we find that reduced YAP1 function disrupts early retinal progenitor development.

A step toward better variant interpretation in developmental eye disorders.

📄 doi.org/10.1016/j.bb...

👏 Great team effort!

#Coloboma #StemCells #Organoids #Genetics #DevelopmentalBiology

The rise of bone marrow organoids as next-generation models for blood formation and failure The bone marrow (BM) serves as the primary site of postnatal hematopoiesis, where hematopoietic stem cells (HSCs) reside within a specialized, hypoxic microenvironment known as the BM niche1. This com...

#WIMMReads🧪
#MRCWIMM Group Leader Abs Khan contributes to a review on bone marrow organoids, highlighting their potential for modelling blood diseases and advancing personalised therapies. Read more 👇

#Haematology #Organoids @abattacks.bsky.social @rdm.ox.ac.uk @medsci.ox.ac.uk #AcademicSky

New organoids offer deeper insights into pediatric brain cancer Researchers from the University of Trento, in collaboration with Bambino Gesù Children's Hospital in Rome, are using biopsy-derived organoids to search for new drugs.

Patient-derived #organoids (PDOs), or tumoroids, for pediatric #braincancer show promise in helping researchers find new drugs and better understand the different responses of #ependymoma and #medulloblastoma tumors.

Qkine human BMP-2 (Qk007) is animal -origin free, carrier free and tag-free. We test every lot for consistent bioactivity lot-to-lot for long-term reproducible stem cell cultures > zurl.co/z42bL

#stemcells #organoids #research #growthfactors

🌍 This #WorldHealthDay, we are advancing #NAMs like #organoids to build a healthier future.
Our collaboration with CelVivo makes 3D cell culture faster, reproducible, and impactful.
✨ Together for health. #Standwithscience.
🔗 Learn more: zurl.co/59E8q
@who.int

Figure showing experimental set-up for ototoxicity study, demonstrating that vibratome sectioning preserves otic vesicles. Panel A illustrates vibratome sectioning of day‑75 IEOs into ~200 µm slices, followed by 48 h recovery and 24 h drug treatment at day 77. Sections were fixed were fixed at 1, 3 or 7 days after treatment. (B) Side-view representative image of an IEO sectioned into 200 µm-thick slices. (C) Top-view representation of a vibratome slice of an IEO, with arrowheads annotating the otic vesicles (inset). Scale bars: 100 µm and 500 µm. (D) Intact morphology of an otic vesicle without vibratoming (I), directly after vibratoming (II) and after 48 h recovery (III), showing Hematoxylin and Eosin (H&E) histological staining, followed by immunofluorescent staining of otic epithelium [CDH1+ (green)/SOX10+ (cyan)] and of otic vesicles containing hair cells (MYO7A+, yellow), neurons (TUBB3+, magenta) and cell nuclei (DAPI+, dark blue). In III, the apparent MYO7A–TUBB3 colocalization likely reflects immature hair cell precursors that transiently co-express neuronal β-III-tubulin during development. Scale bars: 25 µm.

In a new paper in our #InVitroModelling Special Issue, @amylucassen.bsky.social, Heiko Locher & co develop human #iPSC derived inner ear #organoids that reveal ototoxicity in response to cisplatin and gentamicin

doi.org/10.1242/dmm....

BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia - Cell Death & Disease Cell Death & Disease - BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia

#BAP1 overexpression induces early onset #preeclampsia–like features in #placental #organoids: ❌blocked extravillous #trophoblast differentiation
❌impaired syncytialization
🔥persistent pro-inflammatory signatures @cbm-csic-uam.bsky.social @csic.es 👏🥳team! www.nature.com/articles/s41...

Stress tested, testing stress: Novel organoid models how the adrenal gland develops Sitting above each kidney are two small endocrine glands about the size of walnuts. These are the adrenal glands, responsible for producing hormones that help control some of the body's most critical ...

"the organoid was functional: It produced cortisol and androgens in response to adrenocorticotropic hormone, a key signal from the brain that regulates stress responses." medicalxpress.com/news/2026-04... #organoids

Our new manuscript on novel technology for drug development is online (www.nature.com/articles/s42...).
See video summary below . A unique piece that combined #Chemputer, #Drosophila #genetics, #organoids and #kinase profiling. Fun collaboration with @leecronin.bsky.social @rosscagan.bsky.social

Organoids + AI is the convergence everyone in the field is watching right now. ML is being used to stabilize culture conditions, segment morphology in real time, and integrate imaging with spatial omics.
#organoids #stemcells #neuroscience

Through epigenetic profiling of patient-derived #organoids, scientists have shown distinct #BreastCancer subtypes, offering new insights into disease progression and potential therapeutic targets.

🔗 https://bit.ly/4t9FE8k
🎧 https://bit.ly/4sKXLlt

Computational and Structural Biotechnology Journal (CSBJ), a Science Partner Journal published in collaboration with AAAS, is inviting submissions for its upcoming special issue: “Advanced 3D Tissue Models for Improving Translational Pharmacology and Toxicology” For more info about the Call for Papers, please visit: https://spj.science.org/journal/csbj/si/advanced-3d-tissue-models

📢 Call for Papers: Advanced 3D Tissue Models for Improving Translational Pharmacology and Toxicology

⏳ Submission Deadline: 30 November 2026

🔗 Submit your work: spj.science.org/journal/csbj...

#CallForPapers #DrugDiscovery #Toxicology #3DTissueModels #Organoids #PrecisionMedicine #Pharmacology

📖 New Article! 📖

👩‍⚕️ Our first Guiding Principles paper is now live! Read it at https://ow.ly/U5n750YyNHX

Stay tuned for the next two articles in the intestinal #organoids topic series: https://ow.ly/guJ150YyNHW

Congrats to Tiger Jian on leading this innovative study advancing vascularized human organoid systems for therapeutic testing.

Great team science from the Pelletier, Wrana, and Attisano labs.

@sinaihealth.bsky.social @utoronto.bsky.social
#Organoids #HumanModels #VascularBiology

Fig 2 from the linked paper: "Modeling human neural repair using human induced pluripotent stem cells (iPSCs)-derived 2D, 2.5D, and 3D platforms."

🆕 🧠 🩹 @sahoolab.bsky.social of @sasn.rutgers.edu review how hiPSC-based models are changing what's possible for neural repair research & treatment.

#Organoids, #assembloids, & #microengineering can do that too!

🔗 doi.org/10.1016/j.pn...

#RegenerativeMedicine #Neuroskyence #Neuroengineering

🌍 This gives researchers worldwide a powerful starting point to develop therapies to preserve vision.

#AcademicBlueSky #VisionResearch #Ophthalmology #OpenScience #DrugDiscovery #Organoids #Retina #Neuroprotection

A long-term and scalable system to record from neural organoids | King's College London A new brain organoid system helps reduce unwanted variability and scales up experiments for higher throughput drug testing and genetic research.

Brain #organoids have huge potential for 💊 testing drugs, 🧬 researching genetics and 🧠 studying brain development.

New research from @ncndgroup.bsky.social @adampavlinek.bsky.social scales up experiments and reduces variability.

🔗 www.kcl.ac.uk/news/a-long-...

Discover our PhD projects 👩🏻‍🔬
🎥 This month: Kobe Outtier (DC10)
She grows mini retinas from patient cells—also known as retinal organoids—to study CRX-related inherited retinal diseases.
📍 Institute for Neurosciences of Montpellier
#MSCA #InheritedRetinalDisease #ScienceCommunication #Organoids #PhD

Good lesson here. #Organoids and organotypic microtissues are fabulous for particular questions, but probably will always need complementary modelling and human studies. A good modeller knows the limitations and works within those.

Brilliant talk by my colleague Dr Dongli Liu from UNSW at ANZGOG (Australia New Zealand Gynaecological Oncology Group) on the Gold Coast this week. All about development of organoids from patients with ovarian and endometrial cancer & their value in drug testing. #organoids #tumoroids #ANZGOGASM2026

#VirtualPub Don't miss Valentin Dunsing-Eichenauer, Charité Universitätsmedizin Berlin, on "Functional & deep imaging of #organoids via light-sheet #FLIM and two-photon microscopy."
🗓️ Fri, March 27 @ 13:00 CET
Register ⤵️
www.eurobioimaging.eu/events/funct...

Best talk award for our presentation on #SYS #organoids and neuronal models at the Neuro&Rare #ciber meeting

WNV can cause serious brain infections. A new study created human cerebral organoids to better understand the disease. Researchers showed that the WNV infects neurons and astrocytes, causing cell damage. Read further about it 👉 nature.com/articles/s41...

#WestNileVirus #Organoids

#VirtualPub We welcome Valentin Dunsing-Eichenauer, Charité Universitätsmedizin Berlin, on "Functional & deep imaging of #organoids via light-sheet #FLIM and two-photon microscopy."
🗓️ Fri, March 27 @ 13:00 CET
Register ⤵️
www.eurobioimaging.eu/events/funct...

comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders Shen et al. report comBO, a combined human bone and bone marrow model that integrates osteolineage, vascular, stromal, and hematopoietic compartments in a single hiPSC-derived organoid system. comBO s...

This image is from Abs Khan and Yuqi Shen’s recent paper. Read the full paper here: www.cell.com/cell-stem-ce....

#Organoids #3DCellCulture #BoneMarrow #Immunology #CellBiology #SciComm

🧩Unique to Qkine - animal origin-free TGF-β1. View TGF-β1 PLUS™ and buy online > zurl.co/Dxa9C

#stemcells #organoids #nams

Join us June 23–24, 2026, Montpellier, for this first‑edition Complex Organoid Systems with Multifaceted InteraCtions Symposium.
Invited speakers :
Katja Wolthers | Amsterdam
Simon Schäfer | Germany
Céline Cougoule | Toulouse
Alexandre Grassart | Lille

#Organoids
buff.ly/wsgMCQg

Can ‘mini brains’ replace lab animals? Organoids are changing how scientists study disease | The-14 Lab-grown organoids offer a humane alternative to animal testing, helping scientists study diseases more accurately and advance personalized medicine research.

Can ‘mini brains’ replace lab animals? Organoids are changing how scientists study disease
#Science #Organoids #MiniBrains #Biomedical #Research #MedicalInnovation #StemCells #Alzheimers #Autism #Brain #LabGrown #HumanCells #Biotech #Toxicology #Ethics
the-14.com/can-mini-bra...

#Xenopus #Celegans #DevelopmentalBiology #ExperimentalModels #Organoids #AnimalCaps #Review
bsky.app/profile/nico...