NEW article 🎉 mTORC1 (via RAPTOR) rewires amino acid metabolism in lymphatic endothelial cells, disrupting glutaminolysis, altering BCAA handling, and impacting vessel formation. Metabolism is central to lymphatic biology.
#mTORC1 #Lymphatics #Metabolism #VascularBiology
doi.org/10.1016/j.vp...

Congrats to Tiger Jian on leading this innovative study advancing vascularized human organoid systems for therapeutic testing.

Great team science from the Pelletier, Wrana, and Attisano labs.

@sinaihealth.bsky.social @utoronto.bsky.social
#Organoids #HumanModels #VascularBiology

Don't miss out! Register now for the EMBO Workshop "Building networks: Engineering in vascular biology" in #Barcelona, #Spain, 13–15 May 2026.

Deadline: 1 April 2026

www.embl.org/about/info/course-and-co...
#EMBOBuildNetworks #VascularBiology #EMBOevents 🧪

Maybe I can entice you to take a look at the fancy full spectrum flow cytometry figures? There is more where that came from! #endothelialcells #vascularbiology #liver #fibrosis

There's still time to register to attend the "Building networks: engineering in vascular biology" EMBO Workshop, taking place at EMBL Barcelona 13 - 15 May 2026! #vascularbiology #angiogenesis

Register online here ➡️ www.embl.org/about/info/c...

#EMBOBuildNetworks @events.embl.org @embo.org

#WIMMSpotlight #WIMMCommunity #IBDResearch #VascularBiology #Inflammation #EndothelialBiology #TranslationalResearch

WMSM26 Best Abstract: targeting vascular dysfunction and fibrosis in diabetes-induced female sexual dysfunction via allosteric modulation of TG2 (Elif Alan Albayrak, Denmark).
#WMSM26 #SexualMedicine #WomensHealth #Diabetes #TranslationalResearch #Fibrosis #VascularBiology

Green graphic with yellow and white text reads, "Vascular Contributions to Cognitive Impairment and Dementia (VCID) | 3 Reasons to attend | April 28 – May 1, 2026 | Washington University in St. Louis."

Green graphic with yellow and white text reads, "#1 Opportunities to present talks or posters and develop grantsmanship through expert guidance and real-time feedback."

Green graphic with yellow and white text reads, "#2 Engaging seminars cover molecular approaches, mouse models of ADRD and computational methods, highlighting current research and future directions."

Green graphic with yellow and white text reads, "#3 Travel awards available for trainees to support skill development and career momentum. Apply during registration!"

⏰ Submit an abstract by April 3 to present a talk or poster!

@jacksonlab.bsky.social's workshop brings together researchers in #VascularBiology and #Neurodegeneration to advance work in #AlzheimersDisease and related dementias.

🔜 Register: www.jax.org/education-an...

#NeuroSkyence #CompBio #ADRD

Flyer for the Vascular Contributions to Cognitive Impairment and Dementia (VCID) workshop. Visit www.jax.org/vcid for more information.

🧠 Do you study #Neurodegeneration or #VascularBiology?

Join this upcoming workshop bringing together researchers across disciplines to advance foundational and emerging research on Alzheimer's disease and related dementias. ⤵️

🔜 Register now: www.jax.org/education-an...

#NeuroSkyence

New article:
This study reveals that EndMT contributes to atherosclerosis by generating osteogenic- and chondrogenic-like cells, linking endothelial dysfunction to vascular calcification in disease
#EndMT #Atherosclerosis #VascularBiology #CardiovascularScience
doi.org/10.1016/j.vp...

With Tong Xu, @verajanssen.bsky.social and Nathalie Reinhard as shared first authors, we would like to thank everyone who contributed!

#Angiogenesis #VascularBiology #Endothelial #PortWineStains #SturgeWeberSyndrome #AmsterdamUMC

📣 EVBO Seminar this Wednesday with talks by
🔬 @gluxan.bsky.social
🧠 @lbejarano.bsky.social
🧬 Sébastien Dumas
Kindly supported by nanoEntek.
🗓️ Wednesday | 15:00–16:00 CET
💻 Online
I’m happy to chair and moderate and hope many of you can join us!
#EVBO #VascularBiology #EndothelialCells #Seminar

From the latest issue:
Ööbik and colleagues compare arterial vs. venous metabolic profiles in patients with peripheral artery disease —revealing novel metabolic insights in ischemic vascular beds.
🔗 DOI: 10.1177/1358863X251370352
#PeripheralArteryDisease #VascularBiology

Multiple lesion-specific somatic mutations and bi-allelic loss of ACVRL1 in a single patient with hereditary haemorrhagic telangiectasia - European Journal of Human Genetics European Journal of Human Genetics - Multiple lesion-specific somatic mutations and bi-allelic loss of ACVRL1 in a single patient with hereditary haemorrhagic telangiectasia

📢 A new study confirms the “second-hit” model in Hereditary Haemorrhagic Telangiectasia ( #HHT): Multiple lesion-specific ACVRL1 mutations were found in one patient, supporting the somatic mutation-driven formation of telangiectasias and AVMs 🧬 #VascularBiology #EJHG

www.nature.com/articles/s41...

Research Associate (Fixed Term) Postdoctoral Research Associate in vascular cell plasticity and translation (single-cell and omics) (Fixed Term) We invite applicants for a postdoc position (Research Associate) for a project in Dr

Happy New Year!

We are looking for a postdoc with computational expertise to join our group. Deadline for application is 13th January.

www.cam.ac.uk/jobs/researc...

#newjob #postdoc #vascularbiology #atherosclerosis #cellplasticitycontrol #functionalgenomics #cellheterogeneity

Vascular smooth muscle cells are the underrated shapeshifters driving plaque evolution. Our new review unpacks how mechanics, molecular signals, and RNA regulation push vSMCs toward phenotypes that fuel plaque growth and vulnerability.
#Atherosclerosis #VascularBiology #SmoothMuscleCells

Postgraduate Associate – Koh Lab, Yale Stem Cell Center, Department of Comparative Medicine, Yale School of Medicine

postdocs.yale.edu/posts/2025-1...

The Koh Lab is hiring!! Please reach out to join our newly established lab as a postgraduate associate! Come help us write the first exciting chapter of our (hopefully epic) saga! #CraniofacialBM #HSCniche #Vascularbiology #Immunology #YaleStemCellCenter #YaleCMED

Proteomic and Functional Analysis on Endothelial Cell Heterogeneity Identifies Key Regulators in Hyperglycemia-Induced Dysfunction. | American Journal of Physiology-Cell Physiology | American Physiological Society Endothelial cells (ECs) play a critical role in managing vascular homeostasis and neovascularization. EC functions vary significantly depending on their anatomic locations, especially for ECs forming macrovascular versus microvascular vessels. ECs possess heterogeneous signaling pathways, energy metabolism, and cellular behaviors that enable them to handle both physiological and hyperglycemic conditions. These variations can impact the efficacy of pharmacotherapy and influence the likelihood of unexpected side effects. In this study, we compared human aortic ECs (HAECs) and human dermal microvascular ECs (HDMVECs) to observe the functional and proteomic differences potentially contributing to EC heterogeneity. Compared to HAECs, HDMVECs exhibited faster proliferation, but lower migration and permeability. Under high glucose, migration was worsened for both cell types, whereas proliferation was unaffected, and permeability increased for HDMVECs. Using proteomic analysis, we identified 126 proteins whose abundance was significantly different between HAECs and HDMVECs. DAVID analysis revealed their biological processes, cellular compartments, molecular functions, and pathways. under high glucose, WARS1 increased while SOD2 decreased. Reversing WARS1 or SOD2 expression levels improved HDMVEC migration and permeability functions. The combined treatment of WARS1 knockdown and SOD2 overexpression fully restored EC migration and reduced permeability to levels comparable to those of their counterparts under normal glucose conditions. Furthermore, in the cutaneous wound in type 2 diabetic mice, the combination therapy of Wars1 knockdown and SOD2 overexpression accelerated the wound closure and augmented wound angiogenesis. Our studies provide novel molecular insights into EC heterogeneity and identified WARS1 and SOD2 as potential targets for dermal angiogenesis during tissue repair.

Wayne State EACPHS shows microvascular ECs are more vulnerable to high-glucose stress.
🔗 doi.org/10.1152/ajpc...

#Diabetes #VascularBiology #Proteomics

NET1/ARHGEF8 is a mechanosensitive Guanine Exchange Factor controlling vascular smooth muscle cells' contractility Cyclic stretch, generated by pulsatile blood pressure, has been identified as a pivotal regulator of vascular smooth muscle cell (VSMC) behavior and arterial wall homeostasis. Research has demonstrate...

🔬 New preprint !!! 👇
📃 shorturl.at/uTj8m
🧫 We identified NET1/ARHGEF8 as a stretch-sensitive RhoGEF in smooth muscle cells
Thanks to Mary-Adel Mrad and the team for their hard work 💪
#vascularbiology #smoothmusclecell #cyclicstretch↔️
@inserm.fr @cnrsbiologie.bsky.social

4/4
🎯 So next time you hear “turbulent flow” on a scan or in a paper:
Ask — is it really turbulent, or just disturbed?
Because in haemodynamics, language matters.

#Cardiology #VascularBiology #MedicalAccuracy

🚀 EVBO 2026 Conference Sponsorships
Hosting a vascular or cardiovascular meeting? Apply now!
📅 DL: 30th of November, 2025
👉 evbo.org/index.php/ev...
#EVBO #VascularBiology #ConferenceSupport

🌍 EVBO supports your conference!
Apply now for EVBO Conference Sponsorships for vascular & cardiovascular meetings.
👉 evbo.org/index.php/ev... #EVBO #VascularBiology #ConferenceSupport

🌟 EVBO Conference Sponsorships 2026! Planning a (cardio)vascular meeting? Don’t miss your chance to get EVBO support!
👉 evbo.org/index.php/ev...
#EVBO #VascularBiology #ConferenceSupport

Redirecting

Does vessel size truly dictate soluble guanylate cyclase sensitivity? A new commentary on Lubomirov et al. suggests enhanced cinaciguat responses in smaller arteries may reflect hypoxia–reoxygenation and pathological context, not intrinsic diameter effects. #vascularbiology #NOcGMP #sGC

🚀 EVBO Conference Sponsorships 2026! Hosting a (cardio)vascular meeting? Apply now for EVBO support and greater visibility within the community! 👉evbo.org/index.php/evbo-sponsorsh... #EVBO #VascularBiology #ConferenceSupport

🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...

🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...

CARMN orchestrates angiogenesis from behind the opera scenes: signing love letters to the endothelium: www.jci.org/articles/vie...

Shivangi Pande et al. provide a Commentary on Ming Zhai et al. (www.jci.org/articles/vie...)
#Angiogenesis #VascularBiology

Vascular and Lymphatic Dysregulation via Non-EndoMT Col2a1 Signaling in Bisphosphonate-Related Osteonecrosis of the Jaw Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the most severe complications of antiresorptive therapy. Although impaired angiogenesis is commonly observed in BRONJ, the underlying ...

www.biorxiv.org/cgi/content/...
#bonehealth #osteonecrosis #BRONJ #vascularbiology #lymphatics

Online First!
Ööbik and colleagues compare arterial vs. venous metabolic profiles in patients with peripheral artery disease —revealing novel metabolic insights in ischemic vascular beds.
🔗 DOI: 10.1177/1358863X251370352
#PeripheralArteryDisease #CardioSky #VascularBiology