Dr. Jewett's study reveals osteoclasts activate NK, CD3+ T & γδ T cells, with highest IFN-γ secretion when cells interact with zoledronate-treated osteoclasts, offering BRONJ insights.

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#BRONJ #Osteoclasts

Vascular and Lymphatic Dysregulation via Non-EndoMT Col2a1 Signaling in Bisphosphonate-Related Osteonecrosis of the Jaw Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the most severe complications of antiresorptive therapy. Although impaired angiogenesis is commonly observed in BRONJ, the underlying ...

www.biorxiv.org/cgi/content/...
#bonehealth #osteonecrosis #BRONJ #vascularbiology #lymphatics