Oxygen Deprivation and the Aging Brain: A Hidden Trigger for Cognitive Decline - Aging-US Research As we age, our brains become more sensitive to stress and disease. A recent study sheds light on a lesser-known risk: reduced oxygen levels.

✅ Read our #blog post about the #research paper, titled "Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age."

#Summary ⬇️
aging-us.org/2025/06/oxyg...

#aging #trendingwithimpact #brain #microglia #endothelial #oa #peerreview #publishing

Oral–systemic links: periodontal microbes and the blood-brain barrier at Queen Mary University of London on FindAPhD.com PhD Project - Oral–systemic links: periodontal microbes and the blood-brain barrier at Queen Mary University of London, listed on FindAPhD.com

🔬 Using human #endothelial co-culture models, multi-omics and human samples, the project explores microbial–host communication along the oral #microbiome–brain axis.

🔗 Apply via link in the ad
www.findaphd.com/phds/project...

#Paniekaanval OF #Cardiovasculair ?

🫀 #INOCA #ANOCA #MINOCA 🫀
#CMD #CAS #MVA #VSA
#Endothelial #Dysfunction
#Coronary #Vasospasm
#MicrovascularDysfunction
#NOCAD
#coronary #FUNCTION #TESTING ❗️
#Acetylcholine #Adenosine

#Hormoonschommelingen
#MenstrueleCyclus
#Perimenopause

⏰ New preprint from @lizihegarty.bsky.social, @erinwatson.bsky.social, @bainlab.bsky.social & @doctoremmerson.bsky.social shows that 1hr in PFA-based fixative allows detection of #macrophage subsets in the #salivarygland, #pancreas & #kidney while preserving #epithelial & #endothelial architecture

Oxygen Deprivation and the Aging Brain: A Hidden Trigger for Cognitive Decline - Aging-US Research As we age, our brains become more sensitive to stress and disease. A recent study sheds light on a lesser-known risk: reduced oxygen levels.

✅ Read our #blog post about the #research paper, titled "Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age."

#Summary ⬇️
aging-us.org/2025/06/oxyg...

#aging #trendingwithimpact #brain #microglia #endothelial #oa #peerreview #publishing

With Tong Xu, @verajanssen.bsky.social and Nathalie Reinhard as shared first authors, we would like to thank everyone who contributed!

#Angiogenesis #VascularBiology #Endothelial #PortWineStains #SturgeWeberSyndrome #AmsterdamUMC

Dr. Volker Busskamp's lab at @unibonn.bsky.social used #endothelial cells to induce transient vascular support in retinal #organoids.

At later stages, these organoids displayed photoreceptor-driven light responses! 💡

📃 https://bit.ly/49x2UoK
🗨️ https://bit.ly/3ZjiWxM

BMP9 Modulates IL-33 Signaling to Mitigate EndMT in Pulmonary Arterial Hypertension | Hypertension BACKGROUND: Pulmonary arterial hypertension (PAH) is a progressive disorder involving disrupted BMP (bone morphogenetic protein) signaling, pulmonary inflammation, and endothelial-to-mesenchymal trans...

The last work from Clarissa’s thesis is finally published! Hereby we show a new BMP/IL33 interplay in #rare pulmonary arterial hypertension, regulating #endothelial plasticity. @rarascsic.bsky.social www.ahajournals.org/doi/10.1161/... don’t forget to check also the Editorial commentary! #PAH #CVD

Oxygen Deprivation and the Aging Brain: A Hidden Trigger for Cognitive Decline - Aging-US Research As we age, our brains become more sensitive to stress and disease. A recent study sheds light on a lesser-known risk: reduced oxygen levels.

✅ Read our #blog post about the #research paper, titled "Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age."

#Summary ⬇️
aging-us.org/2025/06/oxyg...

#aging #trendingwithimpact #brain #microglia #endothelial #oa #peerreview #publishing

🎓 EDITOR'S CHOICE 🎓

Alessio Daniele and colleagues uncovered #endothelial dysfunction in both fit and untrained males assigned to sit for only 2 hours, which was ablated by preadministration of cocoa containing the #flavanol, (-)-epicatechin🪑 ⏰

physoc.onlinelibrary.wiley.com/doi/10.1113/...

In #diabetes, #endothelial cells are sensitive to changes in blood glucose. Bushell et al. show DHLA supplementation enhances H2S production via 3-MST & improves endothelial function under high glucose conditions, with implications for diabetes treatment.

➡️ doi.org/10.1002/1873-3468.70239

Oxygen Deprivation and the Aging Brain: A Hidden Trigger for Cognitive Decline - Aging-US Research As we age, our brains become more sensitive to stress and disease. A recent study sheds light on a lesser-known risk: reduced oxygen levels.

✅ Read our #blog post about the #research paper, titled "Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age."

#Summary ⬇️
aging-us.org/2025/06/oxyg...

#aging #trendingwithimpact #brain #microglia #endothelial #oa #peerreview #publishing

#Sunitinib is an effective cancer treatment, but can cause #hypertension & #HeartFailure.

Drs. Amit Manhas, Yu Liu, & Dr. Nazish Sayed at @stanfordcvi.bsky.social restored #PIEZO1 expression to reverse sunitinib-induced #endothelial dysfunction.

🔖 https://bit.ly/4s9xrBG
🗨️ https://bit.ly/4p3izlj

a history of #CVD & elevated #Ddimer levels. While the exact mechanism of #thrombosis events has not been elucidated, several features, incl #cytokines, #endothelial injury & complement activation, have been documented as possible attributable factors

Oxygen Deprivation and the Aging Brain: A Hidden Trigger for Cognitive Decline - Aging-US Research As we age, our brains become more sensitive to stress and disease. A recent study sheds light on a lesser-known risk: reduced oxygen levels.

✅ Read our #blog post about the #research paper, titled "Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age."

#Summary ⬇️
aging-us.org/2025/06/oxyg...

#aging #trendingwithimpact #brain #microglia #endothelial #oa #peerreview #publishing

Resistance of #endothelial cells to #SARS-CoV-2 #infection in vitro

Resistance of #endothelial cells to #SARS-CoV-2 #infection in vitro, etidiohnew.blogspot.com/2025/12/resi...

We found #KYN bottlenecks💡in #Microglia 🧠+ #Endothelial cells🧪, revealing synergy🧬points for dual #Inhibitors 🌐+engineered #Probiotics!@mdpiopenaccess.bsky.social #Metabolomics #BrainHealth
👉 www.mdpi.com/2227-9059/13...

Oxygen Deprivation and the Aging Brain: A Hidden Trigger for Cognitive Decline - Aging-US Research As we age, our brains become more sensitive to stress and disease. A recent study sheds light on a lesser-known risk: reduced oxygen levels.

✅ Read our #blog post about the #research paper, titled "Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age."

#Summary ⬇️
aging-us.org/2025/06/oxyg...

#aging #trendingwithimpact #brain #microglia #endothelial #oa #peerreview #publishing

Targeting ESM-1 inhibits spinal metastasis by disrupting tumor-endothelial adhesion - Molecular Biomedicine Molecular Biomedicine -

#Letter
Targeting ESM-1 inhibits spinal metastasis by disrupting tumor-endothelial adhesion doi.org/10.1186/s435...

#ESM_1 #Spinal #metastasis #cancer #mechanism #endothelial #pathway

This study profiles #Endothelial and #ImmuneCells from #Vitrectomy samples of #ProliferativeDiabeticRetinopathy, revealing distinct subtypes driven by immune-mediated vessel clearance or endothelial #MitochondrialDysfunction. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Age, sex, and vessel region affect the vasomotor function and gene expression signature of the aorta in mice Vascular aging is associated with endothelial dysfunction, changes in vascular elasticity or stiffness, and the prevalence of cardiovascular diseases.…

🫀 New in JMCC Plus!

Age, sex & vessel region shape vasomotor function in the descending thoracic #aorta — with #endothelial integrity & relaxation declining with age.

Want to know more- check out Saemann et al.:

sciencedirect.com/science/arti...

#CardioSky @jmccardiology.bsky.social

Aurion Biotech Achieves All Primary, Secondary, and Exploratory Endpoints in AURN001 Phase 1/2 CLARA Trial at 12 Months

www.businesswire.com/news/home/20...

#News #USNews #Business #Medical #Ophthalmology #Endothelial #CornealEndothelial

🔍We mapped enzyme “
#Checkpoints” at single-cell resolution!
📌 #Microglial & #Endothelial hotspots=key regulators!
💡 Found #Sex-specific timing windows & microbial levers that can tilt #Kynurenine away from toxicity and toward protection.
@mdpiopenaccess.bsky.social
👉 www.mdpi.com/2227-9059/13...

Resveratrol Benefits for Heart Health: Unlock the Longevity Protein and Avoid Dosing Mistakes In today's episode we're diving deep into Resveratrol Benefits for Heart Health, the natural compound found in red wine linked to the famous "French Paradox". We explore the sophisticated science behind heart protection, specifically how resveratrol activates the SIRT1 "longevity protein" to promote mitochondrial biogenesis and enhance endothelial function. Learn what the latest clinical breakthroughs reveal about reducing systolic blood pressure and supporting overall cardiovascular aging. Most importantly, we cover the critical dosing recommendations (150-500mg daily of trans-resveratrol) and potential, serious interactions with cardiovascular drugs like blood thinners, ensuring you use this powerful supplement safely and effectively.  All scientific sources can be found here: https://foodnourish.net/resveratrol-benefits-for-heart-health/

📣 New Podcast! "Resveratrol Benefits for Heart Health: Unlock the Longevity Protein and Avoid Dosing Mistakes" on @Spreaker #anti_inflammatory #antioxidant #atherosclerosis #bloodpressure #compound #dosing #endothelial #health #heart #ischemic #longevity #metabolism #mitochondria #paradox

We found #KYN bottlenecks💡in #Microglia 🧠+ #Endothelial cells🧪, revealing synergy🧬points for dual #Inhibitors 🌐+engineered #Probiotics! @mdpiopenaccess.bsky.social #Metabolomics #BrainHealth
👉 www.mdpi.com/2227-9059/13...

Oxygen Deprivation and the Aging Brain: A Hidden Trigger for Cognitive Decline - Aging (Aging-US) Research As we age, our brains become more sensitive to stress and disease. A recent study sheds light on a lesser-known risk: reduced oxygen levels.

✅ Read a #blog post about the #research paper, titled "Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age."

#Summary ⬇️
aging-us.org/2025/06/oxyg...

#aging #trendingwithimpact #brain #microglia #endothelial #oa #peerreview #publishing

Single‐cell transcriptomic analyses of skin vascular endothelial cells in sedentary and voluntary wheel running young mice Physical activity (PA) is a fundamental aspect of preventive medicine, offering profound benefits for cardiovascular health and overall well-being. Despite its widespread benefits, the molecular…

#Transcriptomic analysis on #skin #vascular #endothelial cells from sedentary vs. voluntary wheel running young mice identifies significant upregulation of the transcript encoding #transcription factor #Zbtb16 after #exercise.

doi.org/10.14814/phy...
#CellPhysiology

#ESM1 or #Endocan or #endothelial cell specific molecule 1: a key knot (with #HomoCysteine & #NFKB) of the #metabolic #pathway for #human #health.
Public Open Question .. www.researchgate.net/post/Homocys...

Paper TEXT .. www.researchgate.net/post/Homocys... ........

Recent #Research by Pía C. Burboa of rutgersuniversity.bsky.social et al. observes that the #endothelial TRPV4–Cx43 signalling complex regulates vasomotor tone in resistance #arteries 🔬 ⚙️

🔗 Read the article here: physoc.onlinelibrary.wiley.com/doi/10.1113/...