Description This application is a 371 of PCT/US99/08769 filed Apr. 21, 1999, which claims benefit of No. 60/082,589 filed Apr. 21, 1998, which claims benefit of No. 60/095,993 filed Aug. 10, 1998. FIELD OF THE INVENTION The present invention concerns pharmaceutical compounds and compositions that are useful as tissue protectants, such as neuroprotectants and cardioprotectants. The compounds and compositions may be used, for example, in the treatment of acute ischemic neurological insults or chronic neurodegenerative diseases.

🌱 #Cannabis #Hanfwissen #Wissenschaft

Fühlt sich jemand in der Lage über das #Cannabispatent der US-Regierung zu debattieren? Zu erklären was dieses #Patent6630507 medizinisch und politisch bedeutet ❓ 🙏 ❓ ❓

https://patents.google.com/patent/US6630507B1/en […]

[Original post on mastodon.social]

Tenecteplase for Acute Non–Large Vessel Occlusion 4.5 to 24 Hours After Ischemic Stroke Onset This trial tests whether intravenous tenecteplase thrombolysis initiated between 4.5 and 24 hours after symptom onset benefits patients with acute ischemic stroke due to non–large vessel occlusion wit...

En pac c/ictus isquémico agudo x oclusión de vaso no grande y tej cerebral salvable, tenecteplasa IV 4.5 a 24 h desp del inicio de síntomas aum probab de excelente result funcional a 90d c/riesgo elevado de hemorragia intracraneal sintomática #tenecteplase #ischemic jamanetwork.com/journals/jam...

Older Women With CVD, CVD Features at Higher Risk for Ischemic Colitis Low diastolic blood pressure and multiple antihypertensive medications are linked to higher ischemic colitis risk, while higher fiber intake was protective.

Low diastolic blood pressure and use of multiple hypertensive medications are associated with increased #ischemic #colitis risk among older women.

Read More: https://bit.ly/4aalcwb

Brain-derived tau for monitoring brain injury in acute ischemic stroke Brain-derived tau in plasma reflects the extent of brain injury in acute ischemic stroke, predicts functional outcomes, and detects treatment effects.

Brain-derived tau for monitoring brain injury in acute ischemic stroke - Great work by Steffen Tiedt, his team of ISD researchers and international partners now published in Science Translational Medicine: www.science.org/doi/10.1126/...
🎊🙌 #BD-tau #ischemic

Benefits of #ischemic #preconditioning - This Short Report provides new data that a single session of IC can increase blood pressure in older adults with knee #osteoarthritis, but did not affect other measures of #cardiovascular function.
doi.org/10.14814/phy...
#Ageing #Physiology

Investigating the causes of brain ischaemia: value of arterial spin labelling for perfusion imaging - European Radiology European Radiology -

A new commentary on the diagnostic value of ASL for perfusion imaging 🧠✨

This new commentary by Wilhelm Kuker highlights how #ASL perfusion mapping enriches the imaging workup of patients with suspected #ischemic symptoms.

Stroke, Stroke is about experiencing a stroke the symptoms, challenges, and perplexities before, during, and after having a stroke, and the often long recovery afterward. Told with a sense of wonder and often humor, Stroke, Stroke finds the humor… #poetry #stroke #neurodivergent #brain #ischemic

Cerebri: A Web-App to Reduce Door-to-Treatment Decision Time and Improve Guideline Adherence in Acute Ischemic Stroke | Stroke BACKGROUND: Clinical decision support systems hold promise for improving adherence to guidelines and reducing decision-making time in acute ischemic stroke management. We developed a stroke-specific c...

Cerebri: A Web-App to Reduce Door-to-Treatment Decision Time and Improve Guideline Adherence in Acute #Ischemic #Stroke www.ahajournals.org/doi/10.1161/... #hvhebron #neuro [Text complet]

Hspa8 modulation of immune responses mitigates ischemic brain injury - Genes & Immunity Genes & Immunity - Hspa8 modulation of immune responses mitigates ischemic brain injury

🚨 #Research #alert
#Hspa8 modulation of #immune #responses mitigates #ischemic #brain #injury

#Genes & #Immunity @springernature.com
www.nature.com/articles/s41...

FLP CHAPBOOK OF THE DAY: Stroke, Stroke by Marcella Remund
On SALE: www.finishinglinepress.com/product/stro...

Stroke, Stroke is about experiencing a strokethe symptoms, challenges, and perplexities before, during, and after having a stroke….. #poetry #stroke #neurodivergent #brain #ischemic

Resveratrol Benefits for Heart Health: Unlock the Longevity Protein and Avoid Dosing Mistakes In today's episode we're diving deep into Resveratrol Benefits for Heart Health, the natural compound found in red wine linked to the famous "French Paradox". We explore the sophisticated science behind heart protection, specifically how resveratrol activates the SIRT1 "longevity protein" to promote mitochondrial biogenesis and enhance endothelial function. Learn what the latest clinical breakthroughs reveal about reducing systolic blood pressure and supporting overall cardiovascular aging. Most importantly, we cover the critical dosing recommendations (150-500mg daily of trans-resveratrol) and potential, serious interactions with cardiovascular drugs like blood thinners, ensuring you use this powerful supplement safely and effectively.  All scientific sources can be found here: https://foodnourish.net/resveratrol-benefits-for-heart-health/

📣 New Podcast! "Resveratrol Benefits for Heart Health: Unlock the Longevity Protein and Avoid Dosing Mistakes" on @Spreaker #anti_inflammatory #antioxidant #atherosclerosis #bloodpressure #compound #dosing #endothelial #health #heart #ischemic #longevity #metabolism #mitochondria #paradox

Original post on mastodon.social

https://pubchem.ncbi.nlm.nih.gov/patent/US-6630507-B1 {...makes cannabinoids useful in the treatme.nt and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. ...}

#Hanf #hemp #marijuana #Streeck #NinaWarken […]

#thrombosis #ischemic #CVD #primaryhealthcare

Platelet hyperreactivity and aggregation

are promoted by
gut-liver metabolites, such as
indoxyl sulfate,
phenylacetylglutamine (PAGln),
and TMAO,

and reduced by
sunlight (near-infrared, vitamin D),
and nighttime endogenous melatonin synthesis.

Microglia are prominent producers of inflammatory cytokines during the hyperacute phase of ischemic stroke - Communications Biology In-depth characterization of the hyperacute phase (<3 h) following ischemic stroke reveals severe neuroinflammation before the arrival of brain-infiltrating peripheral immune cells, driven by micro...

#Microglia→early activation #ischemic stroke → #inflammation. Inflammatory #cytokines present in abundance in brain 3 h following stroke onset. Modulate their function → ↑ #stroke recovery. go.nature.com/46QIvLF [open access]

New research on acute intermittent passive stretching (PS) or #ischemic #preconditioning shows each increase #microvascular responsiveness and #muscle oxidative capacity, suggesting PS as a possible intervention for individuals unable to take traditional #exercise.
doi.org/10.14814/phy...
#MyoBlue

In patients with stable #ischemic #HeartDisease or NSTE-ACS, chewing rather than swallowing #ticagrelor may lead to slightly faster inhibition of platelet aggregation at one hour with no increase in MACE or major bleeding. institutionalrepository.aah.org/jpcrr/vol10/...

19th Annual Women and Ischemic Heart Disease Symposium - Cedars-Sinai - Continuing Education (CE) Cedars-Sinai, 19th Annual Women and Ischemic Heart Disease Symposium, 4/11/2025 7:30:00 AM - 4/11/2025 2:00:00 PM, The 19th Annual Women and Ischemic Heart Disease Symposium will explore sex- and gend...

Registration is now open for our 19th Annual #Women & #Ischemic #HeartDisease Symposium
Hope to see you there!
🔗 bit.ly/4fL9Qj1
#CardioSky #MedSky

Howard G. Smith MD, AM on Instagram: "Blood Test Pinpoints Stoke Type In Ambulance A handheld device carried in ambulances can rapidly determine whether a stroke is caused by a blocked brain blood ve... 0 likes, 0 comments - drhowardsmithreports on February 21, 2025: "Blood Test Pinpoints Stoke Type In Ambulance A handheld device carried in ambulances can rapidly determine whether a stroke is caused...

Blood Test Pinpoints Stoke Type In Ambulance: Hand-held device rapidly determines if a stroke is hemorrhagic or ischemic permitting earlier therapy. #stroke #gfap #hemorrhagic #ischemic #ambulance #prehospital
www.instagram.com/drhowardsmit...

Comprehensive analysis of autophagy status and its relationship with immunity and inflammation in ischemic stroke through integrated transcriptomic and single-cell sequencing - Genes & Immunity Genes & Immunity - Comprehensive analysis of autophagy status and its relationship with immunity and inflammation in ischemic stroke through integrated transcriptomic and single-cell sequencing

Comprehensive analysis of #autophagy status and its relationship with #immunity and #inflammation in #ischemic #stroke through integrated #transcriptomic and #singlecell #sequencing

#Genes & #Immunity @springernature.com
www.nature.com/articles/s41...

Interleukin-34 and Its Role in Inflammation and Disease | Nature Research Intelligence Learn how Nature Research Intelligence gives you complete, forward-looking and trustworthy research insights to guide your research strategy.

Interleukin-34 (#IL-34) → regulation of macrophages, → Recruitment and polarization of macrophages→ either promotes healing or contributes to #inflammation depending on their state. Assoc. w cardiac remodeling and dysfunction after #ischemic events, leukemia and other cancers. go.nature.com/42x41TE

We share our collaborative work between #ICN2 (@icn2.bsky.social), #IDIBELL and our spin-off company #PaperdropDx:

"Empowering #Ischemic Stroke Risk Assessment: A #DNA-Based #LateralFlow Assay for #miRNA-638 Detection"

#OpenAccess download: zenodo.org/records/1467...

By Ana Rubio-Monterde et al.

New Directions in #viralInfection -Associated #Ischemic Stroke
pmc.ncbi.nlm.nih.gov/articles/PMC...

assets.cureus.com/uploads/orig...

✨ Why this study matters:

This research shows that a #ML model based on non-contrast cardiovascular MR parameters may discriminate between #ischemic and #non-ischemic #cardiomyopathy, enabling wider access to #cardiovascular #MRI examinations with lower costs and faster imaging acquisition.

Riccardo Cau et al. aimed to derive a #MachineLearning model for the differentiation between #ischemic #cardiomyopathy and #non-ischemic cardiomyopathy on non-contrast cardiovascular magnetic resonance (#CMR).

🎁 Unwrap the whole article here 👇
https://bit.ly/3DcFJUd (Riccardo Cau et al.)

Bili-stained waxy cast surrounded by yeast. #AKI #ischemic #ATN septic shock not #hepatorenal #UrinarySediment #pisseprophet #urinemicroscopy

Cellular casts containing #renal #tubular #epithelial cells and a few WBCs SM-stained (left) and unstained. #AKI due to #ischemic #ATN Plus toxic ATN 2/2 cisplatin #nephrotoxicity #urinarysediment #pisseprophet #spinyourownurine #liquidkidneybiopsy