Day 7: #ticagrelor is usually stopped after 12 months. The ‘dual anti-platelet therapy (DAPT)’ is justified when thrombosis risk is high in the post event period, but once risk drops, the bleeding risk outweighs the anti-thrombotic value. There are exceptions to this & individual assessment needed
Day 5 (cont): Reversal of #ticragelor in emergency is possible via new monoclonal antibody drug Bentracimab. This has been designed to reverse #ticagrelor bleeding and is currently awaiting NICE/NHS approval, as well as FDA review.
Day 4: Mechanism of action #ticagrelor. It is a potent reversible platelet P2Y12 receptor antagonist. This receptor normally promotes platelet aggregation via ADP binding as part of haemostasis. Blocking this pathway inhibits platelet activation/aggregation, exerting an anti-thrombotic effect
Day 3 (cont) #ticagrelor is a CYP3A4 & P-gp substrate & can itself cause inhibition of aforementioned processes. Some ethnic variation in response, for example, Asian populations may have higher bleeding risks
Day 1: The limitations of prodrug clopidogrel drove development of alternative orally active P2Y12 inhibitors for anti-platelet therapy. In 2003, a structure was discovered based on ATP, an endogenous P2Y12 inhibitor. #ticagrelor was licensed EMA 2011
New drug information series starting today '7 days of #ticagrelor'. Enjoy!
¿Por qué murió una mujer esperando un fármaco en Marbella? #Marbella #Andalucía #Sanidad #SAS #VisadoFarmacéutico #Ticagrelor #Cardiología #SeguridadDelPaciente #Farmacia #Noticias #España #CostaDelSol #22denoviembre #felizsabado
donporque.com/murio-mujer-...
CytoSorbents Technology Dramatically Lowers Bleeding Risks in Urgent CABG Patients on Ticagrelor #United_States #Princeton #CytoSorbents #Ticagrelor #CABG
In patients with stable #ischemic #HeartDisease or NSTE-ACS, chewing rather than swallowing #ticagrelor may lead to slightly faster inhibition of platelet aggregation at one hour with no increase in MACE or major bleeding. institutionalrepository.aah.org/jpcrr/vol10/...
#Koronarsyndrom: Neue Erkenntnisse zur #PLATO-Studie mit #Ticagrelor (BRILIQUE)?
Wie valide sind die Daten zu Ticagrelor (BRILIQUE) beim akuten Koronarsyndrom? Zu den Zweifeln an der PLATO-Studie.
www.arznei-telegramm.de/html/2025_02...
Is Ticagrelor better than Clopidogrel? The BMJ Investigation Unit details the controversy and casts doubt about the claims of Ticagrelor superiority. It is an interesting but worrying story.
tinyurl.com/3zu5kunb #ticagrelor
