Congrats to Beth Barton and team on their new #PNAS paper: Fibro-adipogenic progenitor cells from murine SMA muscles are intrinsically adipogenic. #Myoblue tinyurl.com/4kwzbjjp
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#MyoBlue
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New #SkeletalMuscle paper: A Pax7::Foxo1 conditional mouse strain. #Myoblue tinyurl.com/sex3ec52 #aRMS
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New #SkeletalMuscle paper: CtBP1 sustains activity-dependent muscle properties and dampens synaptic, contractile and metabolic changes triggered by denervation. #Myoblue tinyurl.com/2rv75k4f
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New #SkeletalMuscle paper: Integrin αVβ5 regulates myoblast proliferation and differentiation in sarcopenia mice treated with FNDC5 gene delivery. #Myoblue tinyurl.com/b5af287m
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New #NatureComms paper: Humans with function-disrupting variants in the myostatin gene (MSTN) have increased skeletal muscle mass and strength, and less adiposity. #Myoblue tinyurl.com/mhsksrte
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New #MolTherapy paper: Delpacibart Etedesiran Improves the Molecular Pathology of Myotonic Dystrophy Type 1 in the Phase 1/2 MARINA® Study. #Myoblue tinyurl.com/3kbu3ty3
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New #MolTherNucAcids paper: AAV-Mediated Gene Transfer of a Novel Microdystrophin Ameliorates Pathology and Enhances Muscle Function in a Mouse Model of DMD. #Myoblue tinyurl.com/mrxhvrhm
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The picture shows some figures from the manuscript
New preprint alert from our lab 🚨
Lipoxins Regulate Intercalated Disk-Associated Signaling and Immune Remodeling in Dilated Cardiomyopathy
www.biorxiv.org/content/10.6...
#dilated #cardiomyopathy #DCM #cardiac #inflammation #sex-specificity #lipoxin #intercalated-disk #myoblue
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New #StemCells paper: Prostaglandin E2 receptor EP2 is indispensable for maintenance of skeletal muscle stem cells. #Myoblue tinyurl.com/3xu8ryc6
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New #NatureAging paper: Exercise alleviates cognitive dysfunction in Alzheimer’s disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia. #Myoblue tinyurl.com/3r9adfb2
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New mini-review by Cesanelli & colleagues:
Methodological framing in muscle morphology and mechanics: aligning experimental protocols with scientific questions
doi.org/10.1007/s109...
#myoblue #muscle #morphology #mechanics #experimental-protocols
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New researcj article by Fang & colleagues:
Short-duration electrical pulse stimulation induces myokines and mitochondrial adaptations in C2C12 myotubes.
doi.org/10.1007/s109...
#myoblue #C2C12 #myokines #mitochondria
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New article alert! Mini-Review by Roger Kissane:
Assessing muscle morphology and mechanics-one protocol does not fit all.
doi.org/10.1007/s109...
#myoblue #muscle-mechanics #fibre-characterisation
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New #moltherapyadvances paper: Preclinical Evaluation of INS1201 AAV9-Micro-Dystrophin Via CSF Administration as a Potential Therapy for Duchenne Muscular Dystrophy. #Myoblue tinyurl.com/3633sxmx
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New #MolTherapy paper: AUF1 therapy blocks atrophy, promotes regeneration, re-innervation and strength for severe muscle injury. #Myoblue tinyurl.com/3bmnxr8d
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New #SkeletalMuscle paper: Functional and structural pathologies in skeletal muscle of a rat model of Duchenne muscular dystrophy. #Myoblue tinyurl.com/bdxjm3ne
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New #jclinicalinvest paper: Distinct HIF1α and HIF2α functions control skeletal muscle metabolism and erythropoiesis. #Myoblue tinyurl.com/my447mjx
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Nice new work in #jclinicalinvest from @athalackm.bsky.social #BenCosgrove and #DanielBerry: PDGFRbeta signaling restrains myocyte function to limit the regenerative capacity of skeletal muscle. #Myoblue tinyurl.com/yc69zzrb
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New #SkeletalMuscle paper: FGF2 rescues denervation-induced muscle atrophy in Ambystoma mexicanum. #Myoblue tinyurl.com/ybnpjufd
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New #TheLancetNeuro paper: Safety and efficacy of fordadistrogene movaparvovec in ambulatory participants with Duchenne muscular dystrophy (CIFFREO): a phase 3, double-blind, randomised, placebo-controlled study. #Myoblue tinyurl.com/3jyb89va
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New #AJHG paper: Enhanced muscle uptake of chemically optimized miR-23b antisense oligonucleotides as lead compounds for myotonic dystrophy type 1. #Myoblue tinyurl.com/3f64wpdt
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Congrats to Jim Dowling and colleagues for their new #ScienceTM paper: AAV8 gene therapy and dietary insults together precipitate cholestatic liver disease in a mouse model of X-linked myotubular myopathy. #Myoblue tinyurl.com/ctdha2wc
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New #SciReports paper: MyoFuse is a fully AI-based workflow for automated quantification of skeletal muscle cell fusion in vitro. #Myoblue tinyurl.com/4tjbcnvd
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New #AJHG paper: SMN1 variants identified by false-positive SMA newborn screening tests: Therapeutic hurdles and functional and epidemiological solutions. #Myoblue tinyurl.com/2ak3suf4
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New #stemcellreports paper: M-cadherin regulates the formation of adherens junctions and secondary myofibers during fetal myogenesis to determine adult myofiber number and muscle mass. #Myoblue tinyurl.com/mubht234
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New #SkeletalMuscle paper: Unveiling FLNC variants: iPSC-derived myogenic cells as a model to study disease mechanisms. #Myoblue tinyurl.com/3tmzbsu5
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New bioRxiv preprint from Pascal Maire’s group is out! I’m happy to have made a small contribution and to be included as a co-author.
“c-MAF transduces motor neuron firing to sustain fast-glycolytic myofibers and neuromuscular junctions” www.biorxiv.org/content/10.6...
#myoblue
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Huge thanks to Anders Aagaard Hansen @andersaagaard.bsky.social for pushing this project forward, Jacob Egebjerg for model development, and our co-authors for samples, validation, and biochemical analyses.
#MyoBlue #OpenScience
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New #SkeletalMuscle paper: The transcriptomic signature of age and sex is not conserved in human primary myotubes. #Myoblue tinyurl.com/2jf79e87
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New #SkeletalMuscle paper: TRPV1 manipulating polarization of M1/M2 macrophages to promote skeletal muscle regeneration. #Myoblue tinyurl.com/57vytz8v
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