https://www.nature.com/articles/s43587-026-01075-5

New #NatureAging paper: Exercise alleviates cognitive dysfunction in Alzheimer’s disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia. #Myoblue tinyurl.com/3r9adfb2

Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions - Nature Aging Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...

🚨Thrilled to share this exciting new paper by our #FOR5762 project leader @bjornschumacher.bsky.social, published in #NatureAging!

The study uncovers neuron-specific aging patterns and points to potential neuroprotective interventions.

Congratulations! 🎉

www.nature.com/articles/s43...

The Population Neuroscience-Dementia Syndemics Framework to better understand global sex and gender-based risk in low- and middle-income countries - Nature Aging This Perspective proposes the Population Neuroscience-Dementia Syndemics Framework and model to develop knowledge of how multiple factors may interact to perpetuate inequities in dementia, especially ...

Read the full perspective here: 🔗 doi.org/10.1038/s435...

Free access link: 🔗 rdcu.be/eZ7fL

#Dementia #PublicHealth #NatureAging #BrainHealth #GlobalHealth #Neuroscience #HealthEquity #LMIC #BrainHealthEquity

Learning a second language can protect your brain. Here’s how. A new study suggests that everyday multilingual habits—from chatting with neighbors to revisiting a childhood language—may help preserve memory, attention, and brain flexibility as we age.

📰 “Learning a second language can protect your brain”.

Do not miss this publication from #NationalGeographic covering the study published in #NatureAging involving Lucia Amoruso, which reveals that #multilingualism helps keep us younger.

👀👇

www.nationalgeographic.com/health/artic...

Absence of care among community-dwelling older adults with dementia and functional limitations - Nature Aging Using data from the United States, England, Europe, Israel and China, Lin, Qian et al. identify that at least one-fifth of persons with dementia and functional limitations received no care for daily a...

Care is not distributed equally...
💡 Research in Nature Aging

1 in 5 older adults with dementia receives no care for daily needs.
In China, nearly 100% lack formal care.

📄 doi.org/10.1038/s435...

#NatureAging #Dementia #EconSky #HealthInequity #LTC

12/ 🔗 Want to know more or collaborate? DMs open or reach me at adrian.carballo.casla@ki.se #HealthyAging #Multimorbidity #Nutrition #Epidemiology #NatureAging

[1/10] For the first time, we can answer this question with the world's largest neurodegeneration proteomics consortium, GNPC @neuroproteome.bsky.social #GNPC #Neurodegeneration #Proteomics #OpenScience #ADRD #Biomarkers #Parkinsons #ALS #FTD #NatureMedicine #NatureAging #SomaScan #Plasma #CSF

Sarcosine decreases in sarcopenia and enhances muscle regeneration and adipose thermogenesis by activating anti-inflammatory macrophages - Nature Aging Using two cohorts, Liu, Ge, Xiao, Lu and colleagues perform plasma metabolomics and lipidomics, linking reduced sarcosine to sarcopenia diagnosis. In mice, they demonstrate that sarcosine enhances mus...

New #NatureAging paper: Sarcosine decreases in sarcopenia and enhances muscle regeneration and adipose thermogenesis by activating anti-inflammatory macrophages. #Myoblue tinyurl.com/mr28xjkd

Social media card featuring an image of Dr Stefanía Benónísdóttir, first author and Postdoctoral Researcher at Leverhulme Centre for Demographic Science, and our logo with the following quote: 'By consolidating this research, we offer a clearer picture of how genetic factors shape reproductive health. This is essential for advancing healthcare, especially when it comes to infertility and reproductive ageing.' There is also a link to the news story: https://www.demography.ox.ac.uk/news/genetic-basis-fertility-family-and-longevity

🧬 buff.ly/41zhQ3k #ICYMI our recent #NatureAging review revealed how your DNA shapes reproductive health, fertility, and even life expectancy.

@vincentjstraub.bsky.social @melindacmills.bsky.social @leverhulme.bsky.social @oxpop.bsky.social

A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging - Nature Aging This study identifies a novel immune checkpoint in senescent cells that is linked to the ganglioside GD3 and that contributes to the evasion of immune clearance by these cells and to aging and age-rel...

I am thrilled to share that my PhD research project has just been published in @natureportfolio.bsky.social #NatureAging !
We discovered how senescent cells use the ganglioside GD3 as a Senescence Immune Checkpoint to escape immune clearance. #NKcells #Siglec7
www.nature.com/articles/s43...

Societal inequality may reduce brain health: Study - Yes Punjab News Study links socio-economic disparities to brain ageing, dementia, reduced brain volume, and connectivity. Highlights need for targeted global brain health interventions

Societal inequality may reduce brain health: Study yespunjab.com?p=76497

#BrainHealth #DementiaResearch #SocioEconomicDisparities #Neurodegeneration #AlzheimersDisease #GlobalHealth #StructuralInequality #BrainAging #HealthEquity #CognitiveFunction #TrinityCollege #NatureAging #InequalityImpact

Social media card featuring an image of Professor Melinda Mills, senior lead author and Director of the Leverhulme Centre for Demographic Science, and our logo with the following quote: 'As more people delay parenthood to later ages, it is important to understand the genetic factors underpinning an individual’s reproductive health and fertility window.' There is also a link to the news story: https://www.demography.ox.ac.uk/news/genetic-basis-fertility-family-and-longevity

🧬 Our new #NatureAging review shows how #DNA impacts both fertility and overall health. The review identified 159 genetic studies and 37 key genes that are linked to reproductive traits https://buff.ly/3VD5y62

@melindacmills.bsky.social @vincentjstraub.bsky.social @leverhulme.bsky.social

The CALERIE Genomic Data Resource - Nature Aging Ryan and colleagues present multi-tissue, multi-omics, longitudinal datasets from the CALERIE phase 2 randomized controlled trial of caloric restriction in humans, providing a powerful resource for tr...

New #NatureAging paper and resource: The CALERIE Genomic Data Resource. tinyurl.com/yc5kexte

The genetic basis of fertility, family and longevity Published today in Nature Aging, a new review by researchers from Oxford Population Health and the University of Iceland reveals how your DNA shapes reproductive health, fertility, and even life…

📝 https://buff.ly/41zhQ3k A new review in #NatureAging by @oxpop.bsky.social & Iceland Uni reveals how your #DNA shapes reproductive health, fertility, & life expectancy 🧬

@natureportfolio.bsky.social @melindacmills.bsky.social @leverhulme.bsky.social @ox.ac.uk @nuffieldlibrary.bsky.social

A chimeric peptide promotes immune surveillance of senescent cells in injury, fibrosis, tumorigenesis and aging - Nature Aging Ming, Yang, Huang et al. design a chimeric matchmaker peptide, which targets a senescent cell-specific surface marker and modifies the cell surface with polyglutamic acid. This promotes interactions w...

A chimeric peptide promotes immune surveillance of senescent cells in injury, fibrosis, tumorigenesis and aging. #NatureAging

"It induces immune clearance of senescent cells and restores tissue homeostasis, offering a promising direction for aging immunotherapy."

doi.org/10.1038/s435...

Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and Cancer. #NatureAging #Aging #scisky #Medsky #News #Cancer

Open Access
www.nature.com/articles/s43...

How Chronic Social Stress Contributes to Aging. #NatureAging

Life stress can shorten lifespan and increase risk for aging-related diseases, but the biology underlying this phenomenon remains unclear. This study provides a potential mechanism.

Read more
www.nature.com/articles/s43...

#Senescence-associated #EndogenousRetroVirus

#ATF3 ➡️bidirectional transcription of SA-ERV (ERV1 ERVK ERVL ERVL-MaLR)
➡️⏫ RIG-I/MDA5-MAVS- interferon I & #Senescence

SA-ERV transcripts ⏫in skin nerve muscle adipose & blood during👤#Aging

#NatureAging 2024
www.nature.com/articles/s43...

Phase I trial of #NicotinamideRiboside in #ChronicObstructivePulmonaryDisease N=40
NCT04990869
6-wk 2 g oral NR/day

53%⏬sputum IL-8
58%⏬sputum neutrophil
3-fold⏫blood NAD+

⏬#EpigeneticAging (DNA methylation 4 clocks)

+RNAseq Nasal epithelial cell

#NatureAging 2024
www.nature.com/articles/s43...

#Senescence #SpatialTranscriptomics #Xenium

P21-high cell clearance⏫skin wound healing🐭
p21-CreERT2::tdT::DTA

p21-hi cells (mainly fibroblasts EC M1Mφ granulocyte/lymphoid cell) are all enriched in PDGFA MMPs TGFb1/3 MCP1 MIP2

#NatureAging 2024
www.nature.com/articles/s43...
x.com/NatureAging/...

APOE as a destabilizer of Heterochromatin & driver of #Senescence in #MesenchymalStromalCell & Fibroblast

Nuclear ApoE directly binds & disintegrates #NuclearEnvelope via promoting autophagic-lysosomal degradation of NE/Heterochromatin proteins

#NatureAging 2022
www.nature.com/articles/s43...

SGLT2i as #Senolytics
#Aging

#Canagliflozin restored the immune clearance (at least T cell) of senescent cells in HFD🐭#WhiteAdiposeTissue ▶️ improved glucose metabolism

Not a direct seno-killing effect
Instead, ⬆️AICAR-AMPK▶️ ⬇️PD-L1 in senescent cell

#NatureAging 2024
www.nature.com/articles/s43...

#Aging of Human Ovary
#SpatialTranscriptomics #Visium

Aged oocytes
⏫MDK-LRP1 signaling to EC/SMC/theca-stroma/T cell/NK (not Monocyte)

Aging of #GranulosaCell & Theca-Stroma
driven by⏬FoxP1

Ovarian SMC is Mustn1+😁

Cav1 as a #SASP component!?😮

#NatureAging 2024
www.nature.com/articles/s43...

Plasma Membrane Damage (0.005~0.09% SDS) induces Yeast or Fibroblast #Senescence

Activating p53-p21 axis but independently of DNA damage response

Roles of ESCRT (CHMP4B) & Glycoprotein VI

Does PMD-senescence occur in Dysferlin KO?😆

Keiko Kono lab #NatureAging 2024
www.nature.com/articles/s43...

#Aging+#TCell▶️#Atherosclerosis

An Aging Atlas of CD8+ T cells in🐭Spleen+Sorta (AAV-PCSK9+#WesternDiet)

#ClonalExpansion of GranZymeK+CD8+ #EffectorMemory T Cell in aged atherosclerotic plaque

Beautiful work🤩

Dan Tyrrell lab #NatureAging 2023
rdcu.be/drRn7