This #STTT study reveals that #Gaylussacin inhibits CK2-dependent aberrant activation of CTCF to prevent #ChromatinRemodeling in macrophages, thereby suppressing #ParticulateMatter-induced #ChronicObstructivePulmonaryDisease (#COPD). #Medsky

#OpenAccess: doi.org/10.1038/s413...

#chronicobstructivepulmonarydisease exacerbation,.
#congestiveheartfailure exacerbation, #arrhythmia was significantly higher than during the control period This risk remained elevated up to 180 days for some cardiorespiratory events.

COPD: Causes, Symptoms, Investigations, Red Flags & Management
#COPD #VikaasShandily #ChronicObstructivePulmonaryDisease #Pulmonology #RespiratoryMedicine

COPD patients will get access to Dupixent via NHS Almost 30,000 people in England with COPD stand to get access to Dupixent, the first biologic for the devastating disease, after NICE backs its use.

#COPDpatients #Dupixent #dupilumab #NHS #chronicobstructivepulmonarydisease #COPD #biologics #Sanofi #Regeneron #uncontrolledCOPD #lungdisease #COPDtherapies #NICEfinaldraftguidance #COPDflareups #COPDdiagnosis #NICE #NHScostsavings #uncontrolledCOPD #COPDcare
zurl.co/7i5io

Chronic Obstructive Pulmonary Disease (COPD) Causes Chronic obstructive pulmonary disease (COPD) develops due to damage in the airways. COPD causes include smoking, chemical exposure, and more. Learn more here.

Chronic Obstructive #Pulmonary Disease ( #COPD) Causes

How COPD develops:
#Smoking
#Pollution
#Chemicalexposure

#Chronicobstructivepulmonarydisease develops due to damage and #inflammation in the #airways.

resources.healthgrades.com/right-care/c...

Development of a Virtual Home-Based Cycling Intervention for Individuals With Chronic Obstructive Pulmonary Disease: Qualitative Study Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality, and exercise has been shown to reduce both. Health conditions, environmental factors, and logistical challenges are often barriers for participation in pulmonary rehabilitation (PR). Given the barriers many individuals with COPD face when attending health care centers for PR, virtual home-based cycling exercise could be an option. Objective: This study aimed to explore the development of a home-based cycling exercise intervention for individuals with COPD, focusing on aspects such as bicycle selection, app functionality, and pilot testing. Furthermore, it aimed to explore participants' and nonparticipants' attitudes toward the intervention. Methods: Using a phenomenological-hermeneutic approach, data were gathered from 15 semistructured interviews, including test pilots, participants, and nonparticipants. A thematic analysis was used to analyze the data. Results: Thematic analysis identified 8 key themes: bicycle selection, individual guidance needs, geographical and video quality, online connectivity, comfort and accessibility of home-based cycling, flexibility, energy levels, and practical limitations. Findings highlighted a preference for pedal bicycles with adjustable intensity, the importance of flexibility in scheduling, and the autonomy provided by a home-based setup. While participants appreciated the virtual journey on videos, barriers such as lack of energy, stress, and limited space were reported by nonparticipants. Conclusions: Recommendations include enhancing app features and addressing individual needs to improve adherence. The study underscores the potential of tailored home-based exercise interventions in overcoming traditional PR challenges.

JMIR Formative Res: Development of a Virtual Home-Based Cycling Intervention for Individuals With Chronic Obstructive Pulmonary Disease: Qualitative Study #COPD #ChronicObstructivePulmonaryDisease #VirtualRehabilitation #HomeExercise #CyclingForHealth

Merck shells out $10 billion for Verona in bid to diversify beyond Keytruda Merck will buy UK-based Verona Pharma for about $10 billion, the companies said on Wednesday, strengthening the U.S. drugmaker's respiratory treatments as part of efforts to reduce dependence on its blockbuster cancer treatment.

#Reuters #pharma #pharmaceuticals #healthcare #Merck #MSD #lungtherapy #respiratory #Verona #FT #VeronaPharma #lungdiseases #FinancialTimes #inhalable #nonsteroidtreatment #Ohtuvayre #patients #chronicobstructivepulmonarydisease #COPD #Ohtuvayretherapy
www.reuters.com/business/hea...

Evaluation of a Novel eHealth Tool for Pulmonary Rehabilitation in People With Chronic Obstructive Pulmonary Disease: Randomized Controlled Pilot and #feasibility Trial Background: There is a growing interest in eHealth solutions to enhance access to and use of pulmonary rehabilitation for people with chronic obstructive pulmonary disease (COPD). Objective: This study aims to evaluate the #feasibility of a novel eHealth tool (Me&COPD) to support pulmonary rehabilitation concerning #usability, exercise adherence, intensity, progression, and adverse events. Moreover, this study aims to evaluate clinical outcome measures to prepare for a future larger trial. Methods: A multicenter, parallel-group randomized controlled pilot and #feasibility trial was conducted in 6 primary health care centers. People with mild to severe COPD were recruited by physiotherapists at the included health care centers and randomized either to the intervention group with access to Me&COPD for 3 months or to the control group receiving usual care. The Me&COPD tool comprised audio-visual and written self-management strategies, including an individually tailored home-based exercise program and interaction with a physiotherapist. The exercise program was prescribed in a face-to-face meeting with a physiotherapist, and thereafter it was regularly reviewed and adjusted through the eHealth tool. The primary outcome, #usability, was self-assessed at intervention completion in the intervention group and among participating physiotherapists (n=7) using the Swedish version of the Mobile Health App #usability Questionnaire (S-MAUQ). In addition, use data on exercise adherence, intensity, and progression and adverse events were exported from the eHealth tool. Clinical outcomes, assessed by blinded assessors at baseline and 3 months in the intervention and control groups, included exercise capacity, balance, physical activity level, COPD-related symptoms, and health-related quality of life. Descriptive statistics were used for analysis. Results: In total, 22 participants (women: n=12, 55%), aged 72.3 (SD 8.4) years on average, were included in the intervention (n=15) and control (n=7) groups. The mean overall S-MAUQ scores out of 7 (highest possible #usability) were 4.4 (SD 1.5) for participants and 4.5 (SD 1.2) for physiotherapists. Among the subscales, the highest score was assigned to usefulness among participants (S-MAUQ: mean 4.9, SD 1.3) and physiotherapists (S-MAUQ: mean 5.1, SD 1.7). No severe adverse events were registered, although exercise adherence, intensity, and progression evaluation were limited by incomplete exercise session registration. The test procedures and the clinical outcome measures used were found to be feasible for the participants and the assessors. Conclusions: The novel eHealth tool, Me&COPD, seemed feasible in terms of safety and had acceptable #usability among people with COPD and participating physiotherapists. #usability may be improved by better organization of the information and simplification of the exercise diary to enable collection of data on exercise adherence, intensity, and progression through the eHealth tool. The test procedures seemed feasible, although the recruitment process needs further consideration. The effectiveness of the intervention remains to be evaluated in a future larger trial. Trial Registration: ClinicalTrials.gov NCT05086341; https://clinicaltrials.gov/study/NCT05086341

JMIR Formative Res: Evaluation of a Novel eHealth Tool for Pulmonary Rehabilitation in People With Chronic Obstructive Pulmonary Disease: Randomized Controlled Pilot and #feasibility Trial #eHealth #PulmonaryRehabilitation #COPD #ChronicObstructivePulmonaryDisease #DigitalHealth

#Medsky🧪 #Casreport #Pneumomediastinum is defined as presence of free air within the mediastinal space & may occur spontaneously or 2ndary to trauma, procedures ( bronchoscopy, endoscopy,dental procedures,head & neck operations),pulmonary disease (eg, #asthma, #chronicobstructivepulmonarydisease),

Remembering Shirley Temple, born April 23, 1928 and passed away February 10, 2014.

Full Post
www.facebook.com/photo/?fbid=...

. #TodayInNerdHistory #April23 #ShirleyTemple #BrightEyes #CurlyTop #Heidi #COPD #ChronicObstructivePulmonaryDisease ##Birthday #History #News #OTD #FYP #Nerd .

Illustration of lungs, half is red and other half is blue. The patients in the background are also either blue or red. The lungs is surrounded by epithelial cells and #SARS-COV2. A volcano plot is emerging out from the centre #sciart #Scicomm #medsky #Biosky #COVID

Our proposed #coverart for a new study in @cp-iscience.bsky.social, from the labs of @loicguillot.bsky.social ky.social and @olivierterrier.bsky.social 🧪

📖 Full paper: lnkd.in/dSfrd8Z5

#biosky #medsky #lunghealth #COVID #Cysticfibrosis #chronicobstructivepulmonarydisease #sciart #scicomm

Und die Zusammenfassung als Langtext-Fassung findet Ihr hier im Blog: shorturl.at/mfosn
#FOAMio #FOAM #Rettungsdienst #Notfallmedizin #LeitlinienKompakt #COPD #GOLD #ChronischObstruktiveLungenerkrankung #ChronicObstructivePulmonaryDisease

Die Zusammenfassung findet Ihr natürlich auch drüben bei Instagram: shorturl.at/3EOpV
#FOAMio #FOAM #Rettungsdienst #Notfallmedizin #LeitlinienKompakt #COPD #GOLD #ChronischObstruktiveLungenerkrankung #ChronicObstructivePulmonaryDisease

Ab jetzt online - die Zusammenfassung der Leitlinie "Global Strategy for the Diagnosis, Management and Prevention of #COPD" der #GOLD
#FOAMio #FOAM #Rettungsdienst #Notfallmedizin #LeitlinienKompakt #ChronischObstruktiveLungenerkrankung #ChronicObstructivePulmonaryDisease

Activity Trackers in Physical Therapy for People With Chronic Obstructive Pulmonary Disease in the Netherlands: Cross-Sectional Study on Current Use and Implementation Determinants Background: In the Netherlands, 545,900 people suffered from COPD in 2022. Physical therapy following the Royal Dutch Society for Physiotherapy (KNGF) guidelines, for COPD treatment is a proven effective treatment for people with COPD. The revised…

JMIR Formative Res: Activity Trackers in Physical Therapy for People With Chronic Obstructive Pulmonary Disease in the Netherlands: Cross-Sectional Study on Current Use and Implementation Determinants #COPD #ChronicObstructivePulmonaryDisease #PhysicalTherapy #ActivityTracker #eHealth

Phase I trial of #NicotinamideRiboside in #ChronicObstructivePulmonaryDisease N=40
NCT04990869
6-wk 2 g oral NR/day

53%⏬sputum IL-8
58%⏬sputum neutrophil
3-fold⏫blood NAD+

⏬#EpigeneticAging (DNA methylation 4 clocks)

+RNAseq Nasal epithelial cell

#NatureAging 2024
www.nature.com/articles/s43...

Leitlinie „Management of Acute Exacerbation of Chronic Obstructive Pulmonary Disease in the Emergency Department“ der IAEM – FOAMio

Ab jetzt online - die Leitlinie "Management of Acute Exacerbation of #ChronicObstructivePulmonaryDisease in the Emergency Department" der @AssocEmergMedIE: shorturl.at/FSC5u
#FOAMio #FOAM #Rettungsdienst #Notfallmedizin #LeitlinienKompakt #COPD #ChronischObstruktiveLungenErkrankung