This review highlights protein #citrullination as a key #PostTranslationalModification influencing #ChromatinRemodeling & gene transcription, outlining its physiological roles & recent advances in understanding its interplay with other modifications.
Read: doi.org/10.1016/j.ge...
This #STTT study reveals that #Gaylussacin inhibits CK2-dependent aberrant activation of CTCF to prevent #ChromatinRemodeling in macrophages, thereby suppressing #ParticulateMatter-induced #ChronicObstructivePulmonaryDisease (#COPD). #Medsky
#OpenAccess: doi.org/10.1038/s413...
By mapping the metabolic-#Epigenetic-immune axis, this review identifies how the interplay of nutrient competition and #ChromatinRemodeling drives cancer plasticity and #ImmuneEvasion, offering new multitargeted therapeutic strategies.
#STTT #OpenAccess: doi.org/10.1038/s413...
This #STTT review synthesizes the “metabolic-#Epigenetic-immune axis” to show how metabolic-driven #ChromatinRemodeling fuels #ImmuneEvasion, identifying nodal convergence points for next-gen multi-target precision oncology.
#OpenAccess: doi.org/10.1038/s413...
By mapping 3,534 genome-wide binding sites, the study shows PKL coordinates with transcription factors HY5, PIFs, and TCPs to establish permissive chromatin environments for regulated gene expression.
#PekingUniversity #PKUResearch #GeneRegulation #Epigenetics #PlantGenomics #ChromatinRemodeling
The CHD Protein, Kismet, Restricts Synaptic BMP Signaling at Glutamatergic Synapses
Neuroscience Insights
@journals.sagepub.com
journals.sagepub.com/doi/10.1177/...
#chromatinremodeling #synapticplasticity #neurodevelpmentaldisorders #openaccess
Loss of function of chromatin remodeler OsCLSY4 leads to RdDM-mediated mis-expression of endosperm-specific genes affecting grain qualities
Dey, R., Pal, A. et al.
Paper
Details
#ChromatinRemodeling #RNAiDirectedDNAMethylation #GrainQualityGenetics
The #histone variant H2A.Z is key to neurodevelopment—but how is it placed at the right #genes? This new study from @gildastef.bsky.social shows how SRCAP ensures proper H2A.Z loading during neuronal differentiation
buff.ly/tk5PyQe
#Epigenetics #Neuroscience #ChromatinRemodeling
👏 A new study by @jamesaoo7.bsky.social and colleagues published in @naturecomms.bsky.social demonstrates that trans-acting long non-coding RNAs (lncRNAs) direct the SWI/SNF complex to cell type-specific enhancers. #chromatinremodeling #lncRNAs Read more here: cpi-online.de/paperofthemo...
In today’s lesson, we discussed the role of nuclear receptors, transcription factors, and chromatin remodelers in cancer. We also examined the main mutations and their roles during transformation. #CancerBiology #TranscriptionFactors #ChromatinRemodeling
Dual loss of #SMARCA2 & #SMARCA4 is rare. PhD candidate Natisha Field in our gp leads an insightful review in #CancerLetters on poor prognosis malignancies with this loss that impacts on #ChromatinRemodeling. #SWISNF #OvarianCancer #LungCancer #epigenetics. Read here:
10.1016/j.canlet.2024.217282
My #firstpost & curious to rebuild in this space. Keeping an eye on the other for now while trying to understand our polarised world. Celebratory mugs from our last 2 papers for first author students! #ScienceGrit #Science #Genetics #Epigenetics #ChromatinRemodeling #SWISNF #ovariancancer #cancer
A #cryoem model of the RSF–NCP complex reveals distinct binding characteristics compared with the SNF2h–NCP complex and biochemical analyses indicate that RSF possesses unique chromatin-remodeling properties #ChromatinRemodeling #RSF #Nucleosome t.co/ZP6ZglquKq
