This review highlights protein #citrullination as a key #PostTranslationalModification influencing #ChromatinRemodeling & gene transcription, outlining its physiological roles & recent advances in understanding its interplay with other modifications.

Read: doi.org/10.1016/j.ge...

Comprehensive Physiology ☕ Monday Briefing: New TOC- Volume 16, Issue 1! #PostTranslationalModification in #Preeclampsia, #Zebrafish model of #ICH, PSEN1 and #BoneLoss in #AD, and interviews with AEs; this issue is not to be missed! Read more ow.ly/YpRy50YmBGh

This review examines lysine #crotonylation (Kcr) as a widespread #PostTranslationalModification regulating gene expression, #DNArepair, protein stability, and disease, highlighting crosstalk with #acetylation and other PTMs as therapeutic targets.

Read: doi.org/10.1016/j.ge...

Lactylation of the SARS-CoV-2 spike protein is required for viral infection - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Lactylation of the SARS-CoV-2 spike protein is required for viral infection

This letter identifies #lactylation as a novel #PostTranslationalModification on the #SARSCoV2 S protein that enhances ACE2 and TMPRSS2 binding, promotes membrane fusion and #ViralEntry, while inhibition reduces infectivity.

#OpenAccess in #STTT:

Furin‐Mediated Cleavage of Zona Pellucida Proteins Is Essential for Oocyte Development The furin cleavage site mutation leads to a failure in transmembrane transport process of non-modified ZP2 protein. This unsuccessful ZP2 secretion might result in the decreased expression of exocyto...

#Article in #MedComm
Furin-Mediated Cleavage of Zona Pellucida Proteins Is Essential for Oocyte Development doi.org/10.1002/mco2...

#EmptyFollicleSyndrome #FemaleInfertility #FurinCleavage #PosttranslationalModification #ZonaPellucida

21] Facts About: Intracellular Protein Glycosylation

🤯 Did you know proteins inside cells can be glycosylated?! 🔬 Our latest blog post dives into the surprising world of intra-cellular protein glycosylation & its vital role in biology!
👉 research.bidmc.org/ncfg/blog/21...

#glycans #glycosylation #posttranslationalmodification #glycotime