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#WeightLossDrugs #LongTermEffects #HealthConsequences #BodyComposition #MuscleLoss #BoneLoss #WeightRegain #CaseStudy #wellnessadvocate #wellnesscoaching #wellnessfitness #wellnesscenter #HealthRisks #MedicalScience

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Weight Loss is Good, but Maybe Not for Your Bones There's a downside to weight loss that many older adults may not know about: It can speed bone loss. Weight-bearing exercise can help.

Weight Loss is Good, but Not for Your Bones
Many older adults may not know that losing weight speeds bone loss. Weight-bearing exercise or a weighted vest can help. bit.ly/4bAKky7 #seniors #glp1weightloss #bonehealth #BoneDensity #obesitymedicine #agingwell @wakeforest.bsky.social #boneloss #aging

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Comprehensive Physiology ☕ Monday Briefing: New TOC- Volume 16, Issue 1! #PostTranslationalModification in #Preeclampsia, #Zebrafish model of #ICH, PSEN1 and #BoneLoss in #AD, and interviews with AEs; this issue is not to be missed! Read more ow.ly/YpRy50YmBGh

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Measurement of glenoid bone loss and glenoid bone fragment on preoperative 3D-CT. a) Yellow line: diameter of the best-fitting circle outlining the inferior glenoid contour; b) blue line: width of the glenoid defect; c) white line: width of the bone fragment. GBL% was calculated as (b/a) × 100; GBF% as (c/a) × 100.

Measurement of glenoid bone loss and glenoid bone fragment on preoperative 3D-CT. a) Yellow line: diameter of the best-fitting circle outlining the inferior glenoid contour; b) blue line: width of the glenoid defect; c) white line: width of the bone fragment. GBL% was calculated as (b/a) × 100; GBF% as (c/a) × 100.

Patients without recurrence were generally older, had shorter delay from the initial instability event, fewer preoperative instability events, and larger glenoid bone fragment for incorporation in the repair.

#Bone #BoneLoss #CTScan #Orthopedics

ow.ly/2ckt50YbIRY

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The resurgence of Vitamin D deficiency is occurring, leading to consequences such as #boneloss, weakened #immunefunction, & reduced #musclestrength. Key dietary sources include fortified milk, fish, & fortified products such as orange juice that contains added #calcium & #vitaminD. #healthyaging

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#WeightLossDrugs #LongTermEffects #HealthConsequences #BodyComposition #MuscleLoss #BoneLoss #WeightRegain #CaseStudy #wellnessadvocate #wellnesscoaching #wellnessfitness #wellnesscenter #HealthRisks #MedicalScience

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NKD2 directs #MesenchymalStemCell fate toward #osteoblasts, inhibits #osteoclasts via Wnt/β‑catenin and mTORC1, and reduces #boneloss in vivo, highlighting NKD2 as a therapeutic target for #osteoporosis.

#OpenAccess: doi.org/10.1016/j.ge...

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Naked cuticle homolog 2 (NKD2) regulates osteoblast and osteoclast differentiation and improves bone loss in ovariectomized mice.
#NKD2 #Osteoblasts #Osteoclasts #BoneLoss #BoneMetabolism #OsteoporosisModel
doi.org/10.1016/j.ge...

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#WeightLossDrugs #LongTermEffects #HealthConsequences #BodyComposition #MuscleLoss #BoneLoss #WeightRegain #CaseStudy #wellnessadvocate #wellnesscoaching #wellnessfitness #wellnesscenter #HealthRisks #MedicalScience

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TIGAR protects against #GIOP by promoting #osteogenic differentiation and reducing #OxidativeStress through activation of the autophagy–Nrf2–ROS pathway, highlighting TIGAR as a potential therapeutic target for improving #BoneLoss in GIOP.

#OpenAccess: doi.org/10.1016/j.ge...

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#WeightLossDrugs #LongTermEffects #HealthConsequences #BodyComposition #MuscleLoss #BoneLoss #WeightRegain #CaseStudy #wellnessadvocate #wellnesscoaching #wellnessfitness #wellnesscenter #HealthRisks #MedicalScience

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Graphic is The Menopause Society logo and Leading the Conversation tagline and text reading "does hormone therapy prevent bone loss and protect against fracture risk?".

Graphic is The Menopause Society logo and Leading the Conversation tagline and text reading "does hormone therapy prevent bone loss and protect against fracture risk?".

"Question: Does hormone therapy prevent bone loss and protect against fracture risk?
Yes. Hormone therapy is US-government approved for prevention of bone loss and can be used for this purpose in women who do not have contraindications and who are appropriate candidates.
Hormone therapy prevents bone loss and reduces fracture risk in healthy, postmenopausal women, with dose-related effects on bone density. Hormone therapy is not US-government approved for treatment of osteoporosis, and other management strategies should be considered in women with osteoporosis. 
Stopping hormone therapy results in initial rapid bone loss and potentially in transiently increased fracture risk with longer-term protection. 
Unless contraindicated, women with premature menopause should use hormone therapy to prevent bone loss and reduce fracture risk until the average age of menopause when treatment may be reassessed. 
References: 
The 2022 Hormone Therapy Position Statement of The Menopause Society
Discontinuation of Menopausal Hormone Therapy and Risk of Fracture".

"Question: Does hormone therapy prevent bone loss and protect against fracture risk? Yes. Hormone therapy is US-government approved for prevention of bone loss and can be used for this purpose in women who do not have contraindications and who are appropriate candidates. Hormone therapy prevents bone loss and reduces fracture risk in healthy, postmenopausal women, with dose-related effects on bone density. Hormone therapy is not US-government approved for treatment of osteoporosis, and other management strategies should be considered in women with osteoporosis. Stopping hormone therapy results in initial rapid bone loss and potentially in transiently increased fracture risk with longer-term protection. Unless contraindicated, women with premature menopause should use hormone therapy to prevent bone loss and reduce fracture risk until the average age of menopause when treatment may be reassessed. References: The 2022 Hormone Therapy Position Statement of The Menopause Society Discontinuation of Menopausal Hormone Therapy and Risk of Fracture".

Does #hormonetherapy prevent bone loss and protect against fracture risk?

Yes. HT is US-government approved for prevention of #boneloss and can be used for this purpose in appropriate candidates who do not have contraindications.
References: tinyurl.com/22v85s8f tinyurl.com/35kf8h8v

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This study highlights NKD2 as a key regulator of #BoneMetabolism via #Wnt/-catenin and mTORC1 signaling to enhance #Osteogenesis and reduce #Postmenopausal #BoneLoss. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

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#WeightLossDrugs #LongTermEffects #HealthConsequences #BodyComposition #MuscleLoss #BoneLoss #WeightRegain #CaseStudy #wellnessadvocate #wellnesscoaching #wellnessfitness #wellnesscenter #HealthRisks #MedicalScience

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#WeightLossDrugs #LongTermEffects #HealthConsequences #BodyComposition #MuscleLoss #BoneLoss #WeightRegain #CaseStudy #wellnessadvocate #wellnesscoaching #wellnessfitness #wellnesscenter #HealthRisks #MedicalScience

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#Cancer negatively impacts bone health through various mechanisms, including treatment-induced #boneloss and malignant bone lesions. New review explores whether osteoanabolic agents could help, weighing potential benefits against theoretical cancer risks. doi.org/10.1177/2042...

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#WeightLossDrugs #LongTermEffects #HealthConsequences #BodyComposition #MuscleLoss #BoneLoss #WeightRegain #CaseStudy #wellnessadvocate #wellnesscoaching #wellnessfitness #wellnesscenter #HealthRisks #MedicalScience

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#WeightLossDrugs #LongTermEffects #HealthConsequences #BodyComposition #MuscleLoss #BoneLoss #WeightRegain #CaseStudy #wellnessadvocate #wellnesscoaching #wellnessfitness #wellnesscenter #HealthRisks #MedicalScience

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#apsresearch #WTD25 #raredisease #charity #donate #APS #osteoporosis #bonehealth #boneloss #bonelossawareness

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#WeightLossDrugs #LongTermEffects #HealthConsequences #BodyComposition #MuscleLoss #BoneLoss #WeightRegain #CaseStudy #wellnessadvocate #wellnesscoaching #wellnessfitness #wellnesscenter #HealthRisks #MedicalScience

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Could a drug commonly prescribed to older adults accelerate bone loss? Commonly prescribed thyroid drug levothyroxine was linked with bone mass and bone density loss in a cohort of older adults in a recent study.

#Levothyroxine use in people with typical hormone ranges could lead to lower bone mass and density in older people, over time. #osteoperosis #boneloss #aging #drug

www.medicalnewstoday.com/articles/com...

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#WeightLossDrugs #LongTermEffects #HealthConsequences #BodyComposition #MuscleLoss #BoneLoss #WeightRegain #CaseStudy #wellnessadvocate #wellnesscoaching #wellnessfitness #wellnesscenter #HealthRisks #MedicalScience

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NASA’s latest study on mice aboard the International Space Station shows that long-term exposure to microgravity causes significant damage to weight-bearing bones, particularly the femur, while the lumbar spine remains mostly unaffected.

#NASA #Microgravity #SpaceHealth #BoneLoss #ISSResearch

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A direct link between SARS-CoV-2 and bone loss - Nature Reviews Rheumatology Research demonstrates that the SARS-CoV-2 protein ORF8 drives osteoclastogenesis, establishing a direct link between viral infection and bone loss.

www.nature.com/articles/s41...

#boneloss #covid

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Frequent #heartburn is medically known as #GastroesophagealRefluxDisease or GERD for short. Because frequent use of common #GERD medications may lead to increased #boneloss over time, it is important to consume a diet rich in #calcium. #healthyaging #aging

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Leptin potentiates bone loss at skeletal sites distant from focal inflammation in female ob/ob mice Leptin increases focal inflammation and osteolysis induced by polyethylene particles in leptin-deficient ob/ob mice suggesting the adipokine, an important immune modulator, contributes to orthopedic i...

Even more concerning, the bone loss was seen at sites distant from the inflammation. #BoneLoss #Inflammation #Research #AcademicSky

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And building skeletal muscle also helps slow bone loss and reduce falls in later age. #glucose #diabetes #metabolicsyndrome #boneloss #bonehealth #falling
www.mdpi.com/1422-0067/22...

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Building Bone while Making Milk | NEJM In their study of a mouse model of bone loss during lactation, Babey et al. identified a hormone, secreted by brain cells, that enhances bone mass and strength.

www.nejm.org/doi/full/10....

#boneloss #lactation #Rheumsky

“In their study of a mouse model of bone loss during lactation, Babey et al. identified a hormone, secreted by brain cells, that enhances bone mass and strength.”
🐁🦴🧠

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