Potential benefits of #FGF9 + #VaporicAcid in the neuronal (NES+ CHAT+ TH+) differentiation of Human omental adipose-derived #MesenchymalStemCell
What is the differentiation efficiency?

Adding CHIR to VA+F9 actually block neural committment

#AlternLabAnim 2025
journals.sagepub.com/doi/10.1177/...

Host-derived FSTL1 potentiates Ly6C+ monocytes /macrophages recruitment via the CD14/TLR4/NF-κB axis to modulate the hepatic #Fibrotic #ImmuneMicroenvironment, serving as a key #Biomarker for #MesenchymalStemCell therapy outcomes.

#STTT #OpenAccess: doi.org/10.1038/s413...

NKD2 directs #MesenchymalStemCell fate toward #osteoblasts, inhibits #osteoclasts via Wnt/β‑catenin and mTORC1, and reduces #boneloss in vivo, highlighting NKD2 as a therapeutic target for #osteoporosis.

#OpenAccess: doi.org/10.1016/j.ge...

#Exosome from hTERT- #MesenchymalStemCell overexpressing PD-L1 + HGF i.v. Immediately following🐭Stroke
👉⏫Nestin+ neuroblast/astroglia
👉⏬Neural cell apoptosis
👉⏬Pro-inflamm leukocyte ⏫Anti-inflamm leukocyte
👉⏬infarct vol
⏫Neurobehaviors

#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...

In senescent #MesenchymalStemCell

Nanog-induced Proline Biosynthesis via⏫key enzymes PYCR1/2 (not P5CS) ➡️
👉⏫Mitochondria functions via⏫AMPK-Parkin- #Mitopahgy
👉Revert #Senescence
👉⏫TGFβ1-induced #SmoothMuscleCell differentiation

@cp-cellreports.bsky.social 2024
www.cell.com/cell-reports...

The role of MicroRNAs in mesenchymal stem cell differentiation into vascular smooth muscle cells - Cell Division MicroRNAs (miRNAs) are small, noncoding RNA molecules that play a vital role in regulating gene expression, especially in the differentiation of mesenchymal stem cells (MSCs) into vascular smooth musc...

The role of MicroRNAs in #MesenchymalStemCell differentiation into vascular #SmoothMuscleCell

miR-1/-133/-206
miR-143/-145
miR-221/-222-5p
miR-24
miR-181
miR-503

#CellDiv 2025
celldiv.biomedcentral.com/articles/10....

Bladder tissue regeneration using acellular synthetic PRS scaffold + instillation of conditioned medium from #MesenchymalStemCell & CD34+ HSPC

vs blank media
⏫Smooth muscularization
⏫Size of regenerated blood vessel
⏫Innervation
⏫Urodynamics

#AdvTher 2024
onlinelibrary.wiley.com/doi/10.1002/...

Nuclear SIRT3 binds to #Heterochromatin proteins (HP1s/KAP1/Lamin B1/LBR) & maintains Heterochromatin homeostasis in hESC-derived #MesenchymalStemCell

SIRT3 CRISPR KO▶️DNA damage, Heterochromatin loss & #Senescence in MSC, w/o impacting hESC stemness

#NAR_Open 2021
academic.oup.com/nar/article/...

🐷bone marrow #MesenchymalStemCell encapsulated in Alginate #Hydrogel as cell therapy in 🐷model of #LimbIschemia Iliac arterial excision

Some MSCs survive up to 4 wk in vivo

Limb use - force-time impulses✅ trotting pattern✅
Hyperemic perfusion✅

#JAHA 2024
www.ahajournals.org/doi/10.1161/...