Nuclear SIRT3 binds to #Heterochromatin proteins (HP1s/KAP1/Lamin B1/LBR) & maintains Heterochromatin homeostasis in hESC-derived #MesenchymalStemCell

SIRT3 CRISPR KO▶️DNA damage, Heterochromatin loss & #Senescence in MSC, w/o impacting hESC stemness

#NAR_Open 2021
academic.oup.com/nar/article/...