An overview of the molecular mechanisms driving #OrganFibrosis across diverse tissues, the key signaling pathways, the therapeutic strategies for mitigating or reversing #Fibrotic progression and relevant #ClinicalTrials.

#OpenAccess: doi.org/10.1038/s413...

Host-derived FSTL1 potentiates Ly6C+ monocytes /macrophages recruitment via the CD14/TLR4/NF-κB axis to modulate the hepatic #Fibrotic #ImmuneMicroenvironment, serving as a key #Biomarker for #MesenchymalStemCell therapy outcomes.

#STTT #OpenAccess: doi.org/10.1038/s413...

Researchers from the University of Helsinki report new insights into long-term liver injury after Kasai portoenterostomy for BA in a review published in World Journal of Pediatric Surgery.
#Fibrotic liver injury #biliary atresia
Details: doi.org/10.1136/wjps-2025-001098

This #TopicalReview by Dallas E. Altamirano of @johnshopkinssph.bsky.social et al. examines engineering the #immune and #fibrotic response in volumetric muscle loss (VML) 🔎 📜

🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

This research identifies #SMAD4 #SUMOylation as a critical molecular switch in lens fibrosis and highlights SUMO inhibitors as potential novel therapeutic strategies against #Fibrotic #Cataracts. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

Clinical Features Associated With Fatigue in People With #Fibrotic #InterstitialLung Disease: Cross-Sectional Study
onlinelibrary.wiley.com/doi/10.1111/...

TRPC6 knockdown alleviates #RenalFibrosis by reducing the expression of #fibrotic markers and mitigating #apoptosis and #inflammation of primary tubular epithelial cells (PTECs) via downregulating the PI3K/AKT/GSK3β pathway. #medsky

#MostDownloaded: link.springer.com/article/10.1...

🧵6️⃣ ⚡️Therapeutic modality to improve antifibrotic efficacy⚡️

📌 #Zevaquenabant treatment effectively reduces #fibrosis in human precision-cut lung slices (#hPCLS).

📌 Pulmonary delivery of zevaquenabant may offer a more targeted and safer #therapeutic modality for #fibrotic #lung #diseases

🟣 June 29 – #Scleroderma Awareness Day — a rare and often invisible disease that profoundly impacts lives.
#Fibrotic diseases can affect internal organs, including the lungs, heart, and kidneys. Delta4 is involved in initiatives to halt the progressive scarring process with targeted treatments.

SCI members Michael Longaker, Tushar Desai, Howard Chang, & others establish an atlas of pro- and anti-fibrotic factors that underlie lung matrix architecture and implicate fibroblast-associated biological features in modulating #fibrotic progression vs resolution. www.nature.com/articles/s41...

Objective Effects and Patient Preferences for #AmbulatoryOxygen in #Fibrotic #InterstitialLungDisease With Isolated Exertional Hypoxaemia: A Placebo-Controlled 6-Minute Walk Test Study
onlinelibrary.wiley.com/doi/10.1111/...