Epigenetics Update - SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence go.nature.com/47VUKan

#Epigenetics #Cancer #Metastasis #SMAD4
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Discover the breakthrough at epigenometech.com

This research identifies #SMAD4 #SUMOylation as a critical molecular switch in lens fibrosis and highlights SUMO inhibitors as potential novel therapeutic strategies against #Fibrotic #Cataracts. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

#MyhreSyndrome in Adulthood
#SMAD4
N=24

Genotype-Phenotype associations
6 with progressive arterial/aortic stenosis
9 with cardiac diseases
Face2Gene - #FacialGenotyping
Use AI to detect facial traits of genetic diseases

#ejhg_journal 2024 @markelindsay.bsky.social
www.nature.com/articles/s41...

Nature history & phenotype-genotype associations of #MyhreSyndrome #SMAD4
47 case

Aortic Hypoplasia (Z<-2.0) 60% penetrance

Renal artery stenosis 13%

+ Cerebrovascular abnormalities

Am J Med Genet A 2024 @markelindsay.bsky.social
onlinelibrary.wiley.com/doi/full/10....