Potential benefits of #FGF9 + #VaporicAcid in the neuronal (NES+ CHAT+ TH+) differentiation of Human omental adipose-derived #MesenchymalStemCell
What is the differentiation efficiency?
Adding CHIR to VA+F9 actually block neural committment
#AlternLabAnim 2025
journals.sagepub.com/doi/10.1177/...
#FGF9 #HNSCC #HeadandNeckSquamousCellCarcinima
High FGF9 HR=2.5⬇️HNSCC survival
7-gene NOTCH module score➡️
Survival
Immunosuppressive TME
Anti-PD-1 immunotherapy response (low NOTCH score 92%; high 8%)
Chemo sensitivity
#JStomatolOralMaxillofacSurg 2025
www.sciencedirect.com/science/arti...
#FGF9 Poultry 2/2
GWAS 🐣
N=159 hens, 754 eggs
Thermogelled egg yolk water content
Egg number
#BMCGenom 2023
link.springer.com/article/10.1...
#FGF9 Poultry 1/2
GWAS 🦆
N=166 66-wk
Possible link b/w FGF9 SNP & Shaoxing duck (>60% 🇨🇳population) Leg muscle weight (PVE 1.4%)
#BMCGenom 2025
link.springer.com/article/10.1...
Horse🐴 Adipose Transcriptome + Metabolomics
Subcutaneous vs Pericardial
#FGF9 pos corr. MUFA (Monounsaturated fatty acid)
minus corr. SFA PUFA
#FoodChem 2026
www.sciencedirect.com/science/arti...
#FGF9 Adhesive Capsulitis
cytoHubba➡️FGF9 as an AC hub gene
FGF9 ⬆️in 👤AC glenohumeral joint capsule & 🐭Shoulder Stiffness (joint immobilization)
Which cell type?🧐
& FGF9 Ab info?😳
FGF9 ⏫fibroblast proliferation migration & αSMA level
#FrontCellDevBio 2025
www.frontiersin.org/journals/cel...
#FGF9 #Glioblastoma
A possible FGF9-FGFR2-CREB axis in mitochondria biogenesis in cultured glioma cells (U-87 U-251), but not astrocytes (SVG p12)
This paper reads too AI......😩
Wish these results were reproducible😶🌫️
Peptides 2026
www.sciencedirect.com/science/arti...
#FGF9 or FGF2/4/8 ⏫UCP1 in both Brown & White Preadipocytes
FGF-induced UCP1 can be artificially activated by TTNPB
But NOT enhance browning or adipocytic differentiation per se
Non-conventional anti-inflamm effect of UCP1 in preadipocyte
#FASEBJ 2025
faseb.onlinelibrary.wiley.com/doi/10.1096/...
#DiabeticCardiomyopathy #FGF9
FGF9⬇️in db/db 🐭🫀
AAV9-cTnt-FGF9 in db/db🐭
⏫🫀function LVEF LVFS
⏬Myocyte hypertrophy
⏬Myocyte lipid droplet
⏬Interstitial fibrosis
Abrogated by AMPKα2 T172A (domi neg)
FGF9-autophagy-p62-KEAP1-NRF2 cardioprotective axis
#CommsBio 2025
www.nature.com/articles/s42...
#FGF9 renal mRNA (2 RNAseq datasets), renal (glomerular + tubular) protein (IHC), serum level (49 case vs 51 ctrl)⬇️in👤#DiabeticNephropathy
FGF9 protein⬇️in kidney glomeruli & tubule (IHC) in STZ diabetic🐭
FGF9⏬hi glucose-induced #EMT
#JCellMolMed 2025
onlinelibrary.wiley.com/doi/10.1111/...
#FGF9 ➡️Mechanosensitive Osteocyte-to-Osteoblast/Osteoclast signaling in Maxillary Bone formation
#CyclicStretch ➡️⏬FGF9 in MC3T3 preosteoblasts (😆)
FGF9⏫ in underdeveloped🧍♂️Maxilla
FGF9 ⏬osteogenesis &⏫osteoclastogenesis
ATF4/5/6 NR2F1
#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
#SpatialTranscriptomics #ParkinsonsDisease
A role of #FGF9 in Glia #Ferroptosis in PD?😁
+snRNAseq
MPTP🐭 #SubstantiaNigra
FGF9 ⏬in PD Neuron ⏫in PD Ependymal cell
FGF9-to-FGFR1/2/3 (CellChat, likely Neuron-to-Oligodendrocyte/Astrocyte) ⏬in PD
#NPJParkinsonsDis 2025
www.nature.com/articles/s41...
#FGF9 #Senescence #Senomorphic
Secretome (1204 proteins) screening on Senescent features (p21 Cell area Nuclei area) of primary👤lung fibroblast -/+Etoposide
Inducer▶️IFNα5/14/16/17
Inhibitors▶️FGF4/9/20
FGF9⏬SASP in normal/IPF lung fibroblast
#SLASDiscov 2025
www.slas-discovery.org/article/S247...
#FGF9 #Stomach
FGF9 KO🐭
👉Loss of forestomach
👉Failed differentiation of gastric Squamous epithelium
👉⏬Sox2+GATA4- squamous epithelial progenitor
👉Retained glandular epithelium in posterior stomach
👉A panel of HOXa/b/c⏬
Mesenchyme?🧐
#DevDy 2025
anatomypubs.onlinelibrary.wiley.com/doi/full/10....
GWAS Hu Sheep🐑Body Weight
N=567
Ovine 40K SNP chip
#FGF9 is reported as a candidate (➕?➖?😶🌫️) gene associated with Weaning weight
However, no supportive stats available
No genome-wide significant hits on Chr6 Fig 2b
Raw data Not publicly accessible...😒
#Genes_MDPI 2024
www.mdpi.com/2073-4425/15...
#FGF9 as one hub gene for #Obesity & related #InsulinResistance
(What's the Functional role of FGF9? Which cell types express FGF9?)
Re-analysis of 6 transcriptome datasets
Use CytoHubba to rank network nodes/hub genes
#Obesity 2024
onlinelibrary.wiley.com/doi/10.1002/...
#FGF9 Tooth🦷 development
Dental Epithelia-derived FGF9▶️
⏫Mesenchymal FGF3/10▶️
⏫DESC survival & Ameloblast differentiation/enamelization
Another good example of FGF orchestration of developmental epithelia-mesenchyme crosstalk
Stem Cell Res Ther 2024
stemcellres.biomedcentral.com/articles/10....
Our Primer on #FGF9 is In Print Now!
Thanks again for the great Differentiation @rogerslabucd.bsky.social & reviewers🙏
The fundamentals of fibroblast growth factor 9
www.sciencedirect.com/science/arti...
Here is the whole series😋
FGF1/2/3/5/6/7/9/10/12/18/20/21
www.sciencedirect.com/journal/diff...
Fibroblast-derived #FGF9 as a regulator of bone marrow stroma (bone-adipose balance)
🐭Fgf9 S99N/+
->⏬bone marrow Fat at baseline (4 mo) or induced by Ovariectomy
->⏬ #Osteoporosis induced by Ovariectomy
Any impact on HSPCs?
FGF9 is⏫upon #Aging or Ovariectomy
#IJBS 2024
www.ijbs.com/v20p3461.htm
#FGF9 as a negative regulator of Hepatocyte Lipogenesis
#MASH
Adenoviral FGF9
⏬#HepaticSteatosis
⏫#GlucoseTolerance #InsulinSensivity
in🐭#DietInducedObesity
shFGF9 in liver
⏫ #FattyAcidSynthesis #FattyAcidTransport
⏬ #FattyAcidOxidation
#FrontPharmacol 2022
www.frontiersin.org/journals/pha...
(Hypoxic) Cap-independent translation of #FGF9 via IRES-like 5'-UTR binding by DAP5/eIF4G2
RNA tertiary structure (7 stem-loops formed by FGF9 5'-UTR), instead of nucleotide sequence, stabilizes DAP5 occupancy
#RNA 2024
rnajournal.cshlp.org/content/earl...
Nerve-Bone communication
Temporal responses (day 1/14/56) of sensory neurons to bone fracture🤠
#DorsalRootGanglia Neuron-derived #FGF9 (likely Shh as well?)⬆️fracture healing, via pro-proliferative & pro-osteogenic effects on periosteal mesenchymal cells
bioRxiv 2024
www.biorxiv.org/content/10.1...
#FGF9 physically interacts with Integrin αvβ3
FGF9 R108E acts as dominant-negative mutant - ⏬mitogenic+migratory effects of FGF9 (20:1)
Does FGF9 modify integrin signals?
How integrin blockade affect FGF9 signals?😁
Yoshikazu Takada lab Cells_MDPI 2024
www.mdpi.com/2073-4409/13...
Possible protective effects of #FGF9 FGF16 (out of 40 cytokines, 307 SNPs) on #IntracranialAneurysm #SubarachnoidHemorrhage
#MendelianRandomization analysis
INTERVAL (3622 plasma proteins, 3301👤)
AGES (2091 plasma proteins, 5368👤)
Eur J Med Res 2024
eurjmedres.biomedcentral.com/articles/10....
