Proteinase 3 Drives Murine Diabetic Kidney Disease by Mediating Caspase-3-dependent Apoptosis of Podocytes

doi.org/10.1016/j.kint.2026.02.020

#MedSky #NephSky #OpenAccess #diabetes #diabeticnephropathy

USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells

#USP19 promotes high glucose– and fatty acid–induced kidney cell dysfunction by stabilizing TAK1, driving #apoptosis, mitochondrial stress, and PINK1/Parkin pathway disruption, highlighting USP19–TAK1 signaling as a target for #DiabeticNephropathy.
Read: doi.org/10.1007/s115...

Prevalence and Risk Factors of Stroke in Inpatients with Type 2 Diabetes Mellitus in China

A cross-sectional study identified a 13.1% stroke prevalence among #Type2DiabetesMellitus Chinese patients, showing that age, #Hypertension, diabetic duration, and #DiabeticNephropathy are significant independent risk factors.
Read: doi.org/10.1007/s115...

The mTOR pathway plays a central role in diabetic nephropathy progression—highlighting promising therapeutic targets.
#mTOR #DiabeticNephropathy #RenalDisease #TherapeuticTargets #Nephrology
www.sciencedirect.com/science/arti...

Reviewing the pathological mechanisms associated with four distinct resident renal cell types & #ImmuneCells within the #Diabetic environment, highlighting recent research in #mTOR-targeted treatment of #DiabeticNephropathy.

#OpenAccess: doi.org/10.1016/j.ge...

#DiabeticNephropathy

Endothelial Cell FGF13 (a non-secreted FGF) as a Parkin-#Mitophagy inhibitor▶️Mitochondrial dysfunction▶️
⏫Glomerular EC Apoptosis
⏬Glomerular endothelial fenestration
⏫Glomerular Fibrosis
⏫Renal injury
in Diabetic🐭

#Diabetes_ADA 2023
diabetesjournals.org/diabetes/art...

Interesting evidence that FGF9 protects high glucose-induced EMT in vitro

FGF9⏬in human #DiabeticNephropathy

A possible Exosomal circRNA-miRNA-FGF9 regulatory axis (in silico only, needs experimental validation)

@plosone.org 2025
journals.plos.org/plosone/arti...

This review outlines recent progress in treating #DiabeticNephropathy via drugs and molecules targeting the #mTORpathway, offering insights for improved prevention and therapy. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Heterogeneity in the relationships between #albuminuria and glomerular structure in type 1 and type 2 #diabetes.

doi.org/10.1016/j.kint.2025.08.034

#NephySky #MedSky #diabetes #diabeticnephropathy
@uwdeptmedicine.bsky.social

This study identifies the role of USP19 in promoting HK-2 cell dysfunction induced by combined #HighGlucose and #FreeFattyAcid stimulation by stabilizing #TAK1, providing a potential therapeutic strategy for combating #DiabeticNephropathy. #medsky
Read more:
link.springer.com/article/10.1...

Protein UHRF1-mediated dual dysregulation of molecular chaperone GRP78 induces endoplasmic reticulum stress and aggravates #diabeticnephropathy

doi.org/10.1016/j.kint.2025.07.023

#MedSky #NephSky #OpenAccess

This #STTT review summarizes the complex mechanisms underlying the #pathophysiology of #DiabeticNephropathy (DN), outlining recent advances in diagnostic & therapeutic strategies and future directions for managing DN. #medsky

#OpenAccess: doi.org/10.1038/s413...

Is #preeclampsia ever “mild?” Lessons on long-term consequences for offspring from a Danish registry–based study

Commentary by S Jesudason & G Piccoli
doi.org/10.1016/j.kint.2025.05.011

Original article: doi.org/10.1016/j.kint.2025.04.017

#MedSky #NephSky #CKD #diabeticnephropathy #PedsNeph

ℹ️ New Review out!

Current trends in single-cell RNA sequencing applications in diabetes mellitus

👉 buff.ly/1R29Yi1

#DiabetesMellitus #scRNAseq #DiabeticNephropathy

Amir Abdipour from #LomaLindaUniversityMedicalCenter discusses his study on the alignment of AI models with nephrologists when answering patient questions about #diabeticnephropathy.

Watch now: www.youtube.com/watch?v=yqDP...

Read the full article: diabetes.jmir.org/2025/1/e65846/

#AI #LLU

Restoration of branched chain amino acid catabolism improves kidney function in preclinical cardiovascular-kidney- #metabolicsyndrome models

doi.org/10.1016/j.kint.2025.04.025

#OpenAccess #Nephsky #MedSky #chronickidneydisease #CKD #diabeticnephropathy #cardiovasculardisease #CVD #kidney

A nationwide register-based cohort study examined the association between #preeclampsia in mothers and the risk of #kidneydisease in their offspring

doi.org/10.1016/j.kint.2025.04.017

#OpenAccess #chronickidneydisease #CKD #Glomerulonephritis #PedsNeph #NephSky #MedSky #diabeticnephropathy

Painting by Dr. Tiff Caza! @glombandit.bsky.social #ArtofMedicine #CKDAwareness #DiabeticNephropathy

https://www.sciencedirect.com/science/article/pii/S2352304224000576

This bibliometric analysis discusses mTOR signaling-associated pathological mechanisms in various renal cell types within a #diabetic environment & highlights the therapeutic implications of targeting the mTOR pathway in #DiabeticNephropathy. #medsky

#OpenAccess: https://buff.ly/3WHjuwr

Rutin and Glimepiride Combination: A Novel Approach for Managing Diabetes Nephropathy in Streptozotocin Induced Diabetes in Wistar Rats Announcing a new article publication for BIO Integration journal. Diabetes mellitus remains a global health concern, because of its associated complications, including diabetic nephropathy. Glimepirid...

Discover how #Rutin and #Glimepiride synergistically manage #DiabeticNephropathy, improving #glycemiccontrol and renal health in STZ-diabetic models.

Explore more at bio-integration.org/managing-dia...

#BIOI #DiabetesResearch #Science @scienceopen.bsky.social #sciencejournal

What is the Link Between Diabetes and Kidney Disease?


#ACEinhibitors #ARBs #artificialintelligence #biomarkers #BloodSugarControl #chronickidneydisease #CKD #diabetes #diabeticnephropathy #dialysis #GeneticStudies #GFR #glomerularfiltrationrate #Hypertension
thediabeticwriter.com/?p=6293

C3aR antagonist limits podocyte dysfunction in BTBR ob/ob mice

🛠️C3a blockade's therapeutic response in #diabeticnephropathy for preserving podocyte integrity through maintenance of mitochondrial functions

C3aR antagonist limits podocyte dysfunction in BTBR ob/ob mice

🛠️C3a blockade's therapeutic response in #diabeticnephropathy for preserving podocyte integrity through maintenance of mitochondrial functions