Evidence on Bitter taste receptor TAS2R agonist (flufenamic acid) in vasorelaxation of endothelium-denuded 🐷coronary artery ex vivo

#FrontPharmacol 2025
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Alcohol dependence disrupts signaling balance in a stress-processing brain region, according to new findings from the Fardon lab published in #FrontPharmacol. Blocking either pathway reduces relapse-like behavior, while inhibiting both cancels the effect.

Frontiers | Multimode MALDI-MSI deciphers matrine-induced metabolic reprogramming in prostate cancer xenografts: spatial mapping of low-molecular-weight compound alterations BackgroundMatrine, a bioactive isoquinoline alkaloid, exhibits antitumor efficacy by modulating multiple signaling pathways to suppress cancer cell prolifera...

Multimode MALDI-MSI deciphers matrine-induced metabolic reprogramming in prostate cancer xenografts: spatial mapping of low-molecular-weight compound alterations #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Serum metabolomics identifies novel prognostic biomarkers in amanita poisoning BackgroundAmanita poisoning causes 90%–95% of global mushroom-related deaths, yet early prognostic biomarkers for Amanita poisoning are lacking.Methods33 pat...

Serum metabolomics identifies novel prognostic biomarkers in amanita poisoning #FrontPharmacol #MassSpec www.frontiersin.org/journals/pha...

Frontiers | Identification, biotransformation, and neuroprotective potential of the ethanol extract of Alpiniae oxyphyllae fructus in neuroinflammation-related cognitive impairment BackgroundNeuroinflammation is a key pathological mechanism underlying various central nervous system (CNS) disorders. Alpiniae Oxyphyllae Fructus (AOF), the...

Identification, biotransformation, and neuroprotective potential of the ethanol extract of Alpiniae oxyphyllae fructus in neuroinflammation-related cognitive impairment #FrontPharmacol #MassSpec www.frontiersin.org/journals/pha...

Frontiers | Mass spectrometry-guided discovery of novel GCPII inhibitor scaffolds IntroductionThere is an unmet need for therapeutics with a novel mechanism to address Q9 symptoms associated with conditions where aberrant glutamatergic neu...

Mass spectrometry-guided discovery of novel GCPII inhibitor scaffolds #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Comparison of the pharmacokinetic profiles of three triterpenoids after oral administration of a cucurbitacin tablet and nanosuspension by UHPLC-MS/MS IntroductionCucurbitacin, a class of triterpenoid compounds isolated from Pedicellus Melo, possesses various biological activities and is the primary active ...

Comparison of the pharmacokinetic profiles of three triterpenoids after oral administration of a cucurbitacin tablet and nanosuspension by UHPLC-MS/MS #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Synthesis, pharmacokinetic studies, and metabolite analysis of meridianin C in rats using a validated ultra high performance liquid chromatography-tandem mass spectrometry method IntroductionMeridianin C (MC) is a marine-derived indole alkaloid that has demonstrated kinase inhibitory and anti-tumor activities. Despite its diverse biol...

Synthesis, pharmacokinetic studies, and metabolite analysis of meridianin C in rats using a validated ultra high performance liquid chromatography-tandem mass spectrometry method #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Electrochemical simulation of psychotropic drug metabolism compared to in vivo processes using liquid chromatography and mass spectrometry IntroductionPsychotropic drugs strongly affect the human psyche through their ability to modulate the neurotransmitter activity and to treat mental disorders...

Electrochemical simulation of psychotropic drug metabolism compared to in vivo processes using liquid chromatography and mass spectrometry #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Therapeutic drug monitoring of selumetinib in pediatrics: a combined LC-MS/MS and LC-HRMS approach Neurofibromatosis type 1 (NF1) is a genetic disorder characterized by the development of plexiform neurofibromas (PNs), benign yet potentially debilitating t...

Therapeutic drug monitoring of selumetinib in pediatrics: a combined LC-MS/MS and LC-HRMS approach #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Biological potential of Lophosoria quadripinnata fern extract: integration of UHPLC/ESI/QToF/MS analysis, antioxidant activity, molecular docking and molecular dynamics simulation Lophosoria quadripinnata (J.F.Gmel.) C.Chr., a fern species from the Dicksoniaceae family, is widely distributed in Central and South America. This study aim...

Biological potential of Lophosoria quadripinnata fern extract: integration of UHPLC/ESI/QToF/MS analysis, antioxidant activity, molecular docking and molecular dynamics simulation #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Pharmacokinetics and tissue distribution analysis of ginsenoside Rh3 in rats using a novel LC-MS/MS quantification strategy Introduction:Ginsenoside Rh3 (GRh3), a rare ginsenoside, demonstrates diverse pharmacological activities in vitro; however, the lack of pharmacokinetic and t...

Pharmacokinetics and tissue distribution analysis of ginsenoside Rh3 in rats using a novel LC-MS/MS quantification strategy #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Explore the changes of metabolites in feces and serum of acute pancreatitis patients with different etiologies by LC-MS based metabolomics strategy BackgroundAcute pancreatitis (AP) is a common abdominal inflammatory disease, which is mainly caused by gallstones, hyperlipidemia, and so on. Previous studi...

Explore the changes of metabolites in feces and serum of acute pancreatitis patients with different etiologies by LC-MS based metabolomics strategy #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Determination of nine prostaglandins in the arachidonic acid metabolic pathway with UHPLC-QQQ-MS/MS and application to in vitro and in vivo inflammation models BackgroundProstaglandins play a vital role as crucial metabolites and inflammatory indicators within the arachidonic acid (AA) metabolic pathway. Conventiona...

Determination of nine prostaglandins in the arachidonic acid metabolic pathway with UHPLC-QQQ-MS/MS and application to in vitro and in vivo inflammation models #FrontPharmacol #MassSpec www.frontiersin.org/journals/pha...

Frontiers | Bioanalytical assay for the quantification of rucaparib in rat plasma using UPLC-MS/MS: development, and validation for interaction with myricetin Rucaparib is used to treat ovarian cancer patients with BRCA gene mutations. Myricetin, a flavonol that strongly inhibits CYP450, is widely found in natural ...

Bioanalytical assay for the quantification of rucaparib in rat plasma using UPLC-MS/MS: development, and validation for interaction with myricetin #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | A sex-sensitive LC-MS/MS method with isotopic internal standard for prazosin bioequivalence: bridging precision medicine and generic drug policy in China ObjectiveTo develop a rapid, sensitive, and high-throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for prazosin quantification in h...

A sex-sensitive LC-MS/MS method with isotopic internal standard for prazosin bioequivalence: bridging precision medicine and generic drug policy in China #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Liquid chromatography–tandem mass spectrometry assay for the simultaneous determination of apalutamide and its active metabolite N-desmethyl apalutamide, and its application in real-world ... BackgroundApalutamide is used in the treatment of castration-resistant prostate cancer. A simple, specific, selective, and effective liquid chromatography–ta...

Liquid chromatography-tandem mass spectrometry assay for the simultaneous determination of apalutamide and its active metabolite N-desmethyl apalutamide, and its application in real-world patients with castration-resistant prostate cancer #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Development and application of a UHPLC-MS/MS method for the simultaneous determination of firmonertinib and its main metabolite AST-5902 in rat plasma: a study on the in vivo drug interact... Due to the potential occurrence of drug interactions, the combined application of firmonertinib and paxlovid carries a relatively high risk. Nevertheless, as...

Development and application of a UHPLC-MS/MS method for the simultaneous determination of firmonertinib and its main metabolite AST-5902 in rat plasma: a study on the in vivo drug interaction between firmonertinib and paxlovid #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Integrated metabolomics and network pharmacology analysis to reveal the mechanisms of Wenshenyang decoction in the treatment of chronic kidney disease

Integrated metabolomics and network pharmacology analysis to reveal the mechanisms of Wenshenyang decoction in the treatment of chronic kidney disease #FrontPharmacol #MassSpec www.frontiersin.org/journals/pha...

Frontiers | Mechanism of total saponins of Ranunculus ternatus Thunb. in treatment of breast cancer based on liquid chromatography–mass spectrometry and network analysis

Mechanism of total saponins of Ranunculus ternatus Thunb. in treatment of breast cancer based on liquid chromatography-mass spectrometry and network analysis #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | The development of a high-throughput acoustic droplet ejection mass-spectrometry assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological in...

The development of a high-throughput acoustic droplet ejection mass-spectrometry assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of SLC1-A3, -A2 and -A1 in a drug discovery program #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Unveiling the processing mechanism of Hezi-decoction-processed Tiebangchui: a synthesis approach using UPLC-Q-TOF-MS-based metabolomics and DESI-MSI

Unveiling the processing mechanism of Hezi-decoction-processed Tiebangchui: a synthesis approach using UPLC-Q-TOF-MS-based metabolomics and DESI-MSI #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | High-performance liquid chromatography–tandem mass spectrometry for simultaneous determination of 23 antidepressants and active metabolites in human serum and its application in therapeuti...

High-performance liquid chromatography–tandem mass spectrometry for simultaneous determination of 23 antidepressants and active metabolites in human serum and its application in therapeutic drug monitoring #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Innovative applications and future perspectives of chromatography-mass spectrometry in drug research

Innovative applications and future perspectives of chromatography-mass spectrometry in drug research #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Metabolomic and lipidomic profiling of traditional Chinese medicine Testudinis Carapax et Plastrum and its substitutes

Metabolomic and lipidomic profiling of traditional Chinese medicine Testudinis Carapax et Plastrum and its substitutes #FrontPharmacol #MassSpec www.frontiersin.org/journals/pha...

Frontiers | Metabolomics of the effects of Yishenjiangya granules in older adults with hypertension

Metabolomics of the effects of Yishenjiangya granules in older adults with hypertension #FrontPharmacol #MassSpec www.frontiersin.org/journals/pha...

Frontiers | UPLC-MS/MS method for simultaneous determination of pyrantel, praziquantel, febantel, fenbendazole and oxfendazole in dog plasma and its application to a bioequivalence study

UPLC-MS/MS method for simultaneous determination of pyrantel, praziquantel, febantel, fenbendazole and oxfendazole in dog plasma and its application to a bioequivalence study #FrontPharmacol www.frontiersin.org/journals/pha...

Frontiers | Toxicological landscape of Fuzi: a comprehensive study on the spatial distribution of toxicants and regional neurotoxicity variability in zebrafish

Toxicological landscape of Fuzi: a comprehensive study on the spatial distribution of toxicants and regional neurotoxicity variability in zebrafish #FrontPharmacol #MassSpec www.frontiersin.org/journals/pha...

Frontiers | Spatial metabolomics in mental disorders and traditional Chinese medicine: a review

Spatial metabolomics in mental disorders and traditional Chinese medicine: a review #FrontPharmacol #MassSpec www.frontiersin.org/journals/pha...

Frontiers | Compound identification of Shuangxinfang and its potential mechanisms in the treatment of myocardial infarction with depression: insights from LC-MS/MS and bioinformatic prediction

Compound identification of Shuangxinfang and its potential mechanisms in the treatment of myocardial infarction with depression: insights from LC-MS/MS and bioinformatic prediction #FrontPharmacol www.frontiersin.org/journals/pha...