Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression BACKGROUND The noradrenergic locus coeruleus (LC) accumulates pathology early in Alzheimer's disease (AD), with LC dysfunction contributing to symptoms and disease progression. We investigated LC an...

Work from us @imperialbrains.bsky.social @ukdri.ac.uk, driven by Mike David, showing how #locuscoeruleus & #substantianigra integrity affect cognition and behaviour in clinical #AlzheimersDisease. #catecholamines #brainstem #neurodegeneration

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

#SpatialTranscriptomics #ParkinsonsDisease

A role of #FGF9 in Glia #Ferroptosis in PD?😁

+snRNAseq
MPTP🐭 #SubstantiaNigra

FGF9 ⏬in PD Neuron ⏫in PD Ependymal cell

FGF9-to-FGFR1/2/3 (CellChat, likely Neuron-to-Oligodendrocyte/Astrocyte) ⏬in PD

#NPJParkinsonsDis 2025
www.nature.com/articles/s41...

Meaning of #substantianigra SUBSTANTIA NIGRA Heterogeneous portion of the middecephalus and important part of the basal ganglia system . . The compact part contains neurons that in humans are dyed black with the neuromelanin pigment that decreases with ag.. substantia nigra

Significado de #substantianigra SUBSTANTIA NIGRA Porción heterogénea del mesencéfalo y parte importante del sistema de ganglios basales. . La parte compacta contiene neuronas que en los humanos se tiñen de negro con el pigmento neuromelanina que disminuye co.. substantia nigra

Significado de #substantianigra SUBSTANTIA NIGRA Porção heterogênea do middecephalus e parte importante do sistema gânglio basal . . A parte compacta contém neurônios que em humanos são dinamizados de preto com o pigmento neuromelanina que diminui com a i.. substantia nigra

Single-nuclei transcriptomics #SubstantiaNigra 👤#ParkinsonsDisease🤠
23 PD+9 Ctrl

Neuron subtype vulnerability in PD

PD #Perciyte?
⏬PIP2 hydrolysis
⏬Rho GTPase cycle
⏬Actin regulation->
⏬Vasoreactivity #NVC?😆

#ScienceAdvances 2024
www.science.org/doi/full/10....