🚨 Two registrations closing April 15th!
COST Action annual meeting: room registration is closing soon: www.uibk.ac.at/en/projects/...
LC Meeting 2026 in Innsbruck: www.uibk.ac.at/de/congress/...
Rooms are first come, first served!
#LocusCoeruleus #Neuroscience #CA24118 #LCMeeting2026
🚨 Last chance to register for the LC Meeting 2026!
Registration closes April 15th. Rooms at the conference venue are first come, first served. Late registration is open until end of May.
Register: www.uibk.ac.at/de/congress/...
#LocusCoeruleus #Neuroscience #Neurodegeneration #LCMeeting2026
Excited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6...
1/3
#Propofol can directly target the #locuscoeruleus #norepinephrine neurone axons to suppress presynaptic norepinephrine release as an in vivo presynaptic mechanism of its #generalanaesthesia effects
www.bjanaesthesia.org/article/S0007-0912(25)00...
Congrats to Ben Zide, MD student at Brown, for his fantastic poster presentation of his Summer Research Scholarship project on #Loneliness and #LocusCoeruleus intensity at the
@brownmedicine.bsky.social academic symposium yesterday!
@hwameeohlab.bsky.social BrownMICAAD Study
Got with the times + made a BSky to share our new, large-scale spatial RNAseq study of adult human #locuscoeruleus! Co-1st auth and cryostat wizard @heenadivecha.bsky.social squeezed 85 tissue sections into 43 Visium arrays. (1/8)
www.biorxiv.org/content/10.1...
Work from us @imperialbrains.bsky.social @ukdri.ac.uk, driven by Mike David, showing how #locuscoeruleus & #substantianigra integrity affect cognition and behaviour in clinical #AlzheimersDisease. #catecholamines #brainstem #neurodegeneration
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Speakers for ICON symposium on novel measurement & manipulation approaches for neuromodulatory systems! Sept 19, 11:45 am Room Sé
At #ICON? – Join us tomorrow to hear about novel measurement & manipulation approaches for neuromodulatory systems!
🗓️Sept 19,
🕚11:45 am
🏫Room Sé
#ICON2025 #CogNeuro #AcademicSky #LocusCoeruleus #neuroskyence
If you are at #AAIC25, check out Ji-Hyun Kim's posters presenting our new #BrownMICAAD data on #LocusCoeruleus integrity, neural activity, & cognition in young & clinically intact older adults!
Mon (7/28) #455, #967 #OhLabBrown #fMRI #LCscan #XiaoyangHu #JasmineRanieri @heidijacobslab.bsky.social
Great (and lots of) work from Mike David and many colleagues using #pupillometry #EEG #MRI to understand arousal and #locuscoeruleus changes in #AlzheimersDisease. Out now in @braincomms.bsky.social
academic.oup.com/braincomms/a...
The image shows a false-colored confocal microscopy image of the locus coeruleus of a Th-cre mouse. LC-NE neurons have been visualized by an antibody staining against tyrosine hydroxylase (cyan), while cre mediated expression of a reporter protein is visible around the LC (red). Image Credit: Lena S. Eschholz, Alexander Dieter, Chantal Wissing.
This study reveals substantial heterogeneity in #transgene expression patterns when using different strategies to virally transduce #NoradrenergicNeurons of the #LocusCoeruleus, highlighting the need for caution to avoid misinterpretations when studying LC function @plosbiology.org 🧪 plos.io/3IehTKb
The image shows a false-colored confocal microscopy image of the locus coeruleus of a Th-cre mouse. LC-NE neurons have been visualized by an antibody staining against tyrosine hydroxylase (cyan), while cre mediated expression of a reporter protein is visible around the LC (red). Image Credit: Lena S. Eschholz, Alexander Dieter, Chantal Wissing.
This study reveals substantial heterogeneity in #transgene expression patterns when using different strategies to virally transduce #NoradrenergicNeurons of the #LocusCoeruleus, highlighting the need for caution to avoid misinterpretations when studying LC function @plosbiology.org 🧪 plos.io/3IehTKb
The image shows a false-colored confocal microscopy image of the locus coeruleus of a Th-cre mouse. LC-NE neurons have been visualized by an antibody staining against tyrosine hydroxylase (cyan), while cre mediated expression of a reporter protein is visible around the LC (red). Image Credit: Lena S. Eschholz, Alexander Dieter, Chantal Wissing.
This study reveals substantial heterogeneity in #transgene expression patterns when using different strategies to virally transduce #NoradrenergicNeurons of the #LocusCoeruleus, highlighting the need for caution to avoid misinterpretations when studying LC function @plosbiology.org 🧪 plos.io/3IehTKb
Excited to share our new findings: transcutaneous vagus nerve stimulation leads to increases in locus coeruleus activity, which correlate with changes in salivary alpha amylase in older individuals. #locuscoeruleus www.brainstimjrnl.com/article/S193...
Very alert kids raising their hands with questions about the brain 🤓
#locuscoeruleus 🧠🟦
nwnoggin.org
👉👉new paper alert from @labluthi.bsky.social - so proud for talented and determined Dr.Najma Cherrad who opened the lab‘s access to brain-body communication! #sleep #locuscoeruleus #parasympathetic @fbm-unil.bsky.social
A sleep transition concept is a great idea. Sleep stages have different parasympathetic (⬆️non-REM) and sympathetic (⬆️REM) tone. I would pose that the #locuscoeruleus and the sub-coeruleus complex deactivation is also possible given their established role in REM sleep and sympthatetic activation.
Check out our new paper: Locus coeruleus tau validates and informs high-resolution MRI in aging and at the earlist Alzheimer's pathology stages.
#sciencesky #Alzheimers #tau #locuscoeruleus #earlytaupathology
@mghmartinos.bsky.social @mgbresearch.bsky.social
pubmed.ncbi.nlm.nih.gov/40022196/
🧠 El PUNTO AZUL que Regula nuestra Vigilia y Descanso, la Importancia del Locus Coeruleus en el Sueño
👉 ciberninjas.com/conocemos-el...
#Sueño #Cerebro #LocusCoeruleus #SaludMental #Neurociencia #CuidadoDelSueño #Biología #Ciencia
Skipping Week 3 because..life, and straight to Week 4 literature dive with a study delineating the role of #locuscoeruleus 🔵 input to spinal dorsal horn #astrocytes in stress-induced pain sensitization.
SO.MANY.BUZZWORDS. I just couldn’t resist reading this! 1/
www.biorxiv.org/content/10.1...
📝 Short bursts of taVNS, whether real or sham,led to an increase in pupil dilation and an improvement in memory performance over time likely due to the attention-inducing sensory modulation of electrical stimulation
#taVNS #vagusnerv #vagusnervstimulation #locuscoeruleus #memory #memoryperformance
📑 Check it out and have a look at the built taVNS-setup & design ⚡👁️ #LocusCoeruleus #vagusnervstimulation #vagusnerv #taVNS #pupillometry
🚨Short bursts of taVNS ⚡ & 👁️ pupil dilation - as an indirect measure of #LocusCoeruleus (?!) #vagusnerv #taVNS
Link to publication:
www.nature.com/articles/s41...
I systematically tested different frequencies (10 & 25 Hz) and intensities (3 & 5 mA) during 3 sec of short bursts of taVNS
🔵 #LocusCoeruleus alert!
Holy cow... I'm supposed to do something else, but this paper looks amazing! I mean the concept, the implications... wow.
www.cell.com/cell/fulltex...
In an attempt to read more science -and for added peer-pressure & accountability- I decided to draft weekly mini #bluetorials for papers that taught me something new in 2025.
Get ready for lots of #locuscoeruleus content - and wish me luck inviting #skywalker authors into the discussion. 1/
5/5 📈 Moreover, older adults exhibited increased LC activation compared to younger adults, indicating possible compensatory overactivation of a structurally declining LC in ageing.
🧠 Our study shows that assessment of #locuscoeruleus function is a promising biomarker of cognitive aging.
1/5 The #locuscoeruleus (LC), our main source of #norepinephrine (NE) in the brain, declines with age and is a potential epicentre of protein pathologies in #neurodegenerative diseases (ND).
Functional #locuscoeruleus imaging, #fmri, to investigate an #ageing noradrenergic system
📑 link to paper:
www.nature.com/articles/s42...
🧵 see thread below
