Excited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6...

1/3

#Propofol can directly target the #locuscoeruleus #norepinephrine neurone axons to suppress presynaptic norepinephrine release as an in vivo presynaptic mechanism of its #generalanaesthesia effects

www.bjanaesthesia.org/article/S0007-0912(25)00...

Congrats to Ben Zide, MD student at Brown, for his fantastic poster presentation of his Summer Research Scholarship project on #Loneliness and #LocusCoeruleus intensity at the
@brownmedicine.bsky.social academic symposium yesterday!

@hwameeohlab.bsky.social BrownMICAAD Study

Impact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus The locus coeruleus (LC) is a small noradrenergic nucleus in the dorsal pons that sends projections across the brain regulating sleep, arousal, attention, stress responses, and some forms of cognition...

Got with the times + made a BSky to share our new, large-scale spatial RNAseq study of adult human #locuscoeruleus! Co-1st auth and cryostat wizard @heenadivecha.bsky.social squeezed 85 tissue sections into 43 Visium arrays. (1/8)

www.biorxiv.org/content/10.1...

Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression BACKGROUND The noradrenergic locus coeruleus (LC) accumulates pathology early in Alzheimer's disease (AD), with LC dysfunction contributing to symptoms and disease progression. We investigated LC an...

Work from us @imperialbrains.bsky.social @ukdri.ac.uk, driven by Mike David, showing how #locuscoeruleus & #substantianigra integrity affect cognition and behaviour in clinical #AlzheimersDisease. #catecholamines #brainstem #neurodegeneration

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Speakers for ICON symposium on novel measurement & manipulation approaches for neuromodulatory systems! Sept 19, 11:45 am Room Sé

At #ICON? – Join us tomorrow to hear about novel measurement & manipulation approaches for neuromodulatory systems!
🗓️Sept 19,
🕚11:45 am
🏫Room Sé

#ICON2025 #CogNeuro #AcademicSky #LocusCoeruleus #neuroskyence

If you are at #AAIC25, check out Ji-Hyun Kim's posters presenting our new #BrownMICAAD data on #LocusCoeruleus integrity, neural activity, & cognition in young & clinically intact older adults!

Mon (7/28) #455, #967 #OhLabBrown #fMRI #LCscan #XiaoyangHu #JasmineRanieri @heidijacobslab.bsky.social

Pupil-linked arousal, cortical activity, and cognition in Alzheimer’s disease Combining pupillometry, EEG and MRI, David et al. report abnormalities in tonic and phasic arousal in Alzheimer’s disease. Locus coeruleus integrity, peak

Great (and lots of) work from Mike David and many colleagues using #pupillometry #EEG #MRI to understand arousal and #locuscoeruleus changes in #AlzheimersDisease. Out now in @braincomms.bsky.social
academic.oup.com/braincomms/a...

The image shows a false-colored confocal microscopy image of the locus coeruleus of a Th-cre mouse. LC-NE neurons have been visualized by an antibody staining against tyrosine hydroxylase (cyan), while cre mediated expression of a reporter protein is visible around the LC (red). Image Credit: Lena S. Eschholz, Alexander Dieter, Chantal Wissing.

This study reveals substantial heterogeneity in #transgene expression patterns when using different strategies to virally transduce #NoradrenergicNeurons of the #LocusCoeruleus, highlighting the need for caution to avoid misinterpretations when studying LC function @plosbiology.org 🧪 plos.io/3IehTKb

The image shows a false-colored confocal microscopy image of the locus coeruleus of a Th-cre mouse. LC-NE neurons have been visualized by an antibody staining against tyrosine hydroxylase (cyan), while cre mediated expression of a reporter protein is visible around the LC (red). Image Credit: Lena S. Eschholz, Alexander Dieter, Chantal Wissing.

This study reveals substantial heterogeneity in #transgene expression patterns when using different strategies to virally transduce #NoradrenergicNeurons of the #LocusCoeruleus, highlighting the need for caution to avoid misinterpretations when studying LC function @plosbiology.org 🧪 plos.io/3IehTKb

The image shows a false-colored confocal microscopy image of the locus coeruleus of a Th-cre mouse. LC-NE neurons have been visualized by an antibody staining against tyrosine hydroxylase (cyan), while cre mediated expression of a reporter protein is visible around the LC (red). Image Credit: Lena S. Eschholz, Alexander Dieter, Chantal Wissing.

This study reveals substantial heterogeneity in #transgene expression patterns when using different strategies to virally transduce #NoradrenergicNeurons of the #LocusCoeruleus, highlighting the need for caution to avoid misinterpretations when studying LC function @plosbiology.org 🧪 plos.io/3IehTKb

Locus coeruleus fMRI response to transcutaneous auricular vagus nerve stimulation is coupled to changes in salivary alpha amylase Transcutaneous auricular vagus nerve stimulation (taVNS) has shown promise to non-invasively enhance memory in older adults and those with mild cognitive impairment (MCI) [1,2]. Evidence suggests this...

Excited to share our new findings: transcutaneous vagus nerve stimulation leads to increases in locus coeruleus activity, which correlate with changes in salivary alpha amylase in older individuals. #locuscoeruleus www.brainstimjrnl.com/article/S193...

Very alert kids raising their hands with questions about the brain 🤓

#locuscoeruleus 🧠🟦

nwnoggin.org

👉👉new paper alert from @labluthi.bsky.social - so proud for talented and determined Dr.Najma Cherrad who opened the lab‘s access to brain-body communication! #sleep #locuscoeruleus #parasympathetic @fbm-unil.bsky.social

A sleep transition concept is a great idea. Sleep stages have different parasympathetic (⬆️non-REM) and sympathetic (⬆️REM) tone. I would pose that the #locuscoeruleus and the sub-coeruleus complex deactivation is also possible given their established role in REM sleep and sympthatetic activation.

Locus coeruleus tau validates and informs high-resolution MRI in aging and at earliest Alzheimer's pathology stages - PubMed The locus coeruleus (LC) has been identified as a site that develops phosphorylated tau pathology earlier than cerebral cortex. We present data using high-resolution postmortem MRI and validated tau h...

Check out our new paper: Locus coeruleus tau validates and informs high-resolution MRI in aging and at the earlist Alzheimer's pathology stages.

#sciencesky #Alzheimers #tau #locuscoeruleus #earlytaupathology
@mghmartinos.bsky.social @mgbresearch.bsky.social
pubmed.ncbi.nlm.nih.gov/40022196/

El PUNTO AZUL que Regula nuestra Vigilia y Descanso, la Importancia del Locus Voeruleus en el Sueño - CIBERNINJAS El cerebro humano es un sistema complejo y fascinante, donde cada una de sus pequeñas regiones juega un papel clave en funciones vitales como el sueño y la

🧠 El PUNTO AZUL que Regula nuestra Vigilia y Descanso, la Importancia del Locus Coeruleus en el Sueño
👉 ciberninjas.com/conocemos-el...

#Sueño #Cerebro #LocusCoeruleus #SaludMental #Neurociencia #CuidadoDelSueño #Biología #Ciencia

Skipping Week 3 because..life, and straight to Week 4 literature dive with a study delineating the role of #locuscoeruleus 🔵 input to spinal dorsal horn #astrocytes in stress-induced pain sensitization.

SO.MANY.BUZZWORDS. I just couldn’t resist reading this! 1/

www.biorxiv.org/content/10.1...

📝 Short bursts of taVNS, whether real or sham,led to an increase in pupil dilation and an improvement in memory performance over time likely due to the attention-inducing sensory modulation of electrical stimulation
#taVNS #vagusnerv #vagusnervstimulation #locuscoeruleus #memory #memoryperformance

📑 Check it out and have a look at the built taVNS-setup & design ⚡👁️ #LocusCoeruleus #vagusnervstimulation #vagusnerv #taVNS #pupillometry

Evaluating phasic transcutaneous vagus nerve stimulation (taVNS) with pupil dilation: the importance of stimulation intensity and sensory perception - Scientific Reports Scientific Reports - Evaluating phasic transcutaneous vagus nerve stimulation (taVNS) with pupil dilation: the importance of stimulation intensity and sensory perception

🚨Short bursts of taVNS ⚡ & 👁️ pupil dilation - as an indirect measure of #LocusCoeruleus (?!) #vagusnerv #taVNS

Link to publication:
www.nature.com/articles/s41...

I systematically tested different frequencies (10 & 25 Hz) and intensities (3 & 5 mA) during 3 sec of short bursts of taVNS

Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep Norepinephrine oscillations during NREM sleep drive synchronized changes in cerebral blood volume and cerebrospinal fluid, promoting glymphatic clearance. Optogenetic and pharmacological manipulations confirm that vasomotion, regulated by norepinephrine, acts as a pump for brain fluid transport.

🔵 #LocusCoeruleus alert!

Holy cow... I'm supposed to do something else, but this paper looks amazing! I mean the concept, the implications... wow.

www.cell.com/cell/fulltex...

In an attempt to read more science -and for added peer-pressure & accountability- I decided to draft weekly mini #bluetorials for papers that taught me something new in 2025.

Get ready for lots of #locuscoeruleus content - and wish me luck inviting #skywalker authors into the discussion. 1/

5/5 📈 Moreover, older adults exhibited increased LC activation compared to younger adults, indicating possible compensatory overactivation of a structurally declining LC in ageing.

🧠 Our study shows that assessment of #locuscoeruleus function is a promising biomarker of cognitive aging.

1/5 The #locuscoeruleus (LC), our main source of #norepinephrine (NE) in the brain, declines with age and is a potential epicentre of protein pathologies in #neurodegenerative diseases (ND).

Functional locus coeruleus imaging to investigate an ageing noradrenergic system - Communications Biology Functional locus coeruleus (LC) imaging revealed that older adults exhibited increased LC activation compared to younger adults, indicating possible compensatory overactivation of a structurally decli...

Functional #locuscoeruleus imaging, #fmri, to investigate an #ageing noradrenergic system

📑 link to paper:
www.nature.com/articles/s42...

🧵 see thread below

Immunohistochemical staining in brain tissue depicting stress-activated neurons (red and/or yellow) distributed around noradrenergic cells of the locus coeruleus (cyan)

Can't get enough of the #bluespot! a galaxy within us 🤩

#neuroskyence #locuscoeruleus #FluorescenceFriday

Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep cycle - Nature Neuroscience Lüthi and colleagues show that activity of the locus coeruleus (LC) is crucial for the cyclic alternation between non-rapid-eye-movement and rapid-eye-movement sleep. Stressful experiences during waki...

🔵 blue spot alert: Anita Luethi's team reports a dual role of #locuscoeruleus in #sleep in Nature Neuroscience @natureportfolio.bsky.social

1) high LC activity facilitates cortical microarousals
2) low LC activity is required for NREMS-to-REMS transitions

doi.org/10.1038/s415...