The image shows a false-colored confocal microscopy image of the locus coeruleus of a Th-cre mouse. LC-NE neurons have been visualized by an antibody staining against tyrosine hydroxylase (cyan), while cre mediated expression of a reporter protein is visible around the LC (red). Image Credit: Lena S. Eschholz, Alexander Dieter, Chantal Wissing.

This study reveals substantial heterogeneity in #transgene expression patterns when using different strategies to virally transduce #NoradrenergicNeurons of the #LocusCoeruleus, highlighting the need for caution to avoid misinterpretations when studying LC function @plosbiology.org 🧪 plos.io/3IehTKb

The image shows a false-colored confocal microscopy image of the locus coeruleus of a Th-cre mouse. LC-NE neurons have been visualized by an antibody staining against tyrosine hydroxylase (cyan), while cre mediated expression of a reporter protein is visible around the LC (red). Image Credit: Lena S. Eschholz, Alexander Dieter, Chantal Wissing.

This study reveals substantial heterogeneity in #transgene expression patterns when using different strategies to virally transduce #NoradrenergicNeurons of the #LocusCoeruleus, highlighting the need for caution to avoid misinterpretations when studying LC function @plosbiology.org 🧪 plos.io/3IehTKb

The image shows a false-colored confocal microscopy image of the locus coeruleus of a Th-cre mouse. LC-NE neurons have been visualized by an antibody staining against tyrosine hydroxylase (cyan), while cre mediated expression of a reporter protein is visible around the LC (red). Image Credit: Lena S. Eschholz, Alexander Dieter, Chantal Wissing.

This study reveals substantial heterogeneity in #transgene expression patterns when using different strategies to virally transduce #NoradrenergicNeurons of the #LocusCoeruleus, highlighting the need for caution to avoid misinterpretations when studying LC function @plosbiology.org 🧪 plos.io/3IehTKb