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#Perciyte
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#GouldSyndrome

Col4a1 G1344D/+ or G394V/+🐭

👁️Retinal vascular defects
1⃣Ectopic NG2+ #Perciyte coverage of P7 retinal vessels
2⃣⏫SM α-actin+ or calponin+ 1-mo arteriolar zone
3⃣⏬2nd+3rd ordered arteriole# (1-mo)
+⏫CNS (Other organs?) TGFβ (How?)🤓

#MatrixBiol 2023
www.sciencedirect.com/science/arti...

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Single-nuclei transcriptomics #SubstantiaNigra 👤#ParkinsonsDisease🤠
23 PD+9 Ctrl

Neuron subtype vulnerability in PD

PD #Perciyte?
⏬PIP2 hydrolysis
⏬Rho GTPase cycle
⏬Actin regulation->
⏬Vasoreactivity #NVC?😆

#ScienceAdvances 2024
www.science.org/doi/full/10....

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