#MarfanSyndrome #Dermopathy

Fbn1 G234D/G234D🐭3~4-wk old exhibit Tight Skin

Compartmentalized matrix alteration
👉Dermis elastin⏬ FBN1⏬
👉#PanniculusCarnosus muscle-fascia interface elastin⏬
👉Fascia elastin⏫ FBN1↔️

Hiromi Yanagisawa lab #MatrixBiol 2025
www.sciencedirect.com/science/arti...

#TGFβ1 #MRTFA #VocalFold

👤VF myofibroblast -/+TGFβ1
▶️activated SRF miR-29 GATA1
▶️fibro-contractile phenotype

SRF MRTFA ⏫in injured🐭VF epithelium+mesenchyme

CCG-257081 (MRTFAi)⏬🐭VF scarring
⏬epithelial thickening ⏬GAG ⏫fibrosis

#MatrixBiol 2025
www.sciencedirect.com/science/arti...

Spatial Localization of Collagen Hydroxylated Proline Site Variation as an Ancestral Trait in the Breast Cancer Microenvironment Collagen stroma interactions within the extracellular microenvironment of breast tissue play a significant role in breast cancer, including risk, prog…

Spatial Localization of Collagen Hydroxylated Proline Site Variation as an Ancestral Trait in the Breast Cancer Microenvironment #MatrixBiol #MassSpec www.sciencedirect.com/science/arti...

A nice comparative study on
1⃣FGF2 2⃣FGF9 3⃣TGFβ1 4⃣TGFβ3 on

1⃣Proliferation 2⃣Migration 3⃣ECM 4⃣Myofibroblastic differentiation of

cultured 1⃣human gingival fibroblasts
2⃣periodontal ligament cells

Douglas Hamilton lab #MatrixBiol 2025
www.sciencedirect.com/science/arti...

#GouldSyndrome

Col4a1 G1344D/+ or G394V/+🐭

👁️Retinal vascular defects
1⃣Ectopic NG2+ #Perciyte coverage of P7 retinal vessels
2⃣⏫SM α-actin+ or calponin+ 1-mo arteriolar zone
3⃣⏬2nd+3rd ordered arteriole# (1-mo)
+⏫CNS (Other organs?) TGFβ (How?)🤓

#MatrixBiol 2023
www.sciencedirect.com/science/arti...