Stroke in autoimmune rheumatic diseases Patients with ARDs have a significantly increased risk for stroke. Review the epidemiology, pathophysiological mechanisms, clinical characteristics, prevention strategies, and post-stroke…

Patients with #ARDs have a significantly increased risk for #stroke.

Review the epidemiology, pathophysiological mechanisms, clinical characteristics, prevention strategies, and post-stroke rehabilitation in this patient population.

👉 buff.ly/KQ66kPC

#RheumSky

Tirzepatide boosts ixekizumab benefits in patients with PsA and obesity Combining ixekizumab with tirzepatide offers additive clinical benefits over ixekizumab alone in the treatment of psoriatic arthritis in patients with overweight or obesity.

#MedNews - Combining #ixekizumab with #tirzepatide offers additive clinical benefits over ixekizumab alone in the treatment of psoriatic #arthritis in patients with overweight or obesity.

Full story 👉 buff.ly/W3uyUrY

#RheumSky

Immunomodulation of the Ocular Surface in Severe Dry Eye Disease: Expert-Driven Literature Review on Treatment Strategies with Description of Representative Challenging Cases Autoimmune-related dry eye disease is often refractory to conventional first-line treatments, with anti-inflammatory and immunomodulatory therapies crucial for long-term control. This stepwise…

Autoimmune-related DED is often refractory to conventional first-line treatments, with anti-inflammatory and immunomodulatory therapies instead crucial for long-term control.

This stepwise approach provides insights from real-world cases.

👉 buff.ly/ZCZmnMx

#EyeSky #RheumSky

A case of VEXAS syndrome presenting as macrophage activation syndrome: from chronic inflammation to multi-organ failure This case highlights the importance of heightened clinical suspicion, early identification, and treatment of macrophage activation syndrome in individuals with VEXAS syndrome.

#MedCase - This case highlights the importance of heightened clinical suspicion, early identification, and treatment of macrophage activation syndrome in individuals with #VEXAS syndrome.

👉 buff.ly/28lIqPH

#RheumSky

Findings support treat-to-target over symptom-driven management for gout A treat-to-target approach may be better than symptom-driven care for improving long-term gout control without increasing the risk for adverse events.

#MedNews - A treat-to-target approach may be better than symptom-driven care for improving long-term #gout control without increasing the risk for adverse events.

Full story 👉 buff.ly/2XahIX4

#RheumSky

A case of VEXAS syndrome presenting as macrophage activation syndrome: from chronic inflammation to multi-organ failure This case highlights the importance of heightened clinical suspicion, early identification, and treatment of macrophage activation syndrome in individuals with VEXAS syndrome.

#MedCase - This case highlights the importance of heightened clinical suspicion, early identification, and treatment of macrophage activation syndrome in individuals with #VEXAS syndrome.

👉 buff.ly/AMySYLh

#RheumSky

The association between 10-year cardiovascular risk and fracture incidence in postmenopausal women: a prospective analysis from the Women's Health Initiative A higher 10-year predicted CVD risk was associated with higher MOF and hip fracture risk after adjustment for sociodemographic, lifestyle, and clinical factors. CVD risk may have implications for frac...

Published in @lancetrh-americ.bsky.social

The association between 10-year #cardiovascular risk and #fracture incidence in #postmenopausal #women: a prospective analysis from the Women's Health Initiative www.thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky #CardioSky #RheumSky

Novel score predicts mortality risk in systemic sclerosis Early mortality in patients with systemic sclerosis who are eligible for intensive therapies can be predicted with the novel RESIST score.

#MedNews - Early mortality in patients with systemic #sclerosis who are eligible for intensive therapies can be predicted with the novel RESIST score.

Full story 👉 buff.ly/jlvtbUy

#RheumSky #SSc

Infrared thermography in the detection of arthritis: a systematic review of diagnostic performance compared with joint ultrasound Early detection of arthritis is critical to prevent irreversible damage. Joint ultrasound offers high sensitivity and availability in routine clinical practice, but it has limitations. Could infrared…

Early detection of #arthritis is critical to prevent irreversible damage. Joint ultrasound offers high sensitivity and availability in routine clinical practice, but it has limitations.

Could infrared thermography play a role?

👉 buff.ly/TF2zd9w

#RheumSky

Novel advances in juvenile idiopathic arthritis associated uveitis Juvenile idiopathic arthritis-associated uveitis is an important cause of childhood and adult visual impairment. Explore recent developments in disease stratification, imaging, pharmacologic…

Juvenile idiopathic #arthritis-associated uveitis is an important cause of childhood and adult visual impairment.

Explore recent developments in disease stratification, imaging, pharmacologic management, and psychosocial support.

👉 buff.ly/CB2Yrna

#RheumSky #PediatricMed

Osteopenia: a key target for fracture prevention Osteopenia was originally a qualitative term denoting bone that appeared to be less dense on radiographs. Since 1994, it has also had the quantitative meaning of a bone mineral density (BMD) T-score b...

Although patients with #osteoporosis are generally at higher #fracture risk than are patients with osteopenia, most fractures occur in the larger group of adults with #osteopenia www.thelancet.com/journals/lan...
#BoneHealth

#MedSky #EndoSky #RheumSky

The potential role for artificial intelligence in fracture risk prediction Osteoporotic fractures are a major health challenge in older adults. Despite the availability of safe and effective therapies for osteoporosis, these therapies are underused in individuals at high ris...

Clinical integration of AI–ML algorithms has the potential to transform #osteoporosis management, offering a more personalised approach to reduce the burden of osteoporotic #fractures www.thelancet.com/journals/lan...
#ArtificialIntelligence

#MedSky #EndoSky #RheumSky

NEW podcast episode 🎧

As part of our theme issue on patient and public involvement in rheumatology, Aisling O'Brien talks to Jon Lampa about patient-reported outcomes from the NORD-STAR trial

Listen on
Apple bit.ly/4rYkOYD
Spotify bit.ly/4cdG4oB

Full Article bit.ly/411D48I
#Medsky #Rheumsky

Granulomatosis with polyangiitis masquerading as a hydatid cyst: a diagnostic pitfall A woman with a history of hepatic echinococcosis presented with pulmonary lesions that did not improve with antiparasitic therapy, prompting rheumatologic evaluation and a diagnosis of granulomatosis…

#MedCase - A woman with a history of hepatic #echinococcosis presented with pulmonary lesions that did not improve with antiparasitic therapy, prompting rheumatologic evaluation and a diagnosis of granulomatosis with polyangiitis.

👉 buff.ly/91dMp7h

#RheumSky

Early detection and intervention in dermatomyositis: current evidence and clinical implications How does early diagnosis of dermatomyositis influence disease progression and physical function? What barriers hinder timely identification and what strategies can enhance early detection and…

How does early diagnosis of #dermatomyositis influence disease progression and physical function?

What barriers hinder timely identification and what strategies can enhance early detection and expedite treatment initiation?

Find out here 👉 buff.ly/obmGDHW

#RheumSky

Although weight loss in people with #obesity has many health benefits, it can also have adverse #skeletal effects, with increased #bone loss and #fracture risk thelancet.com/journals/lan...
#osteoporosis #weightloss #GLP-1 receptor agonists #BariatricSurgery

#MedSky #EndoSky #RheumSky

Osteoporosis in men is a common but often overlooked disorder by clinicians www.thelancet.com/journals/lan...
#osteoporosis #MensHealth

#MedSky #EndoSky #RheumSky

Ixekizumab may offer additional treatment option for juvenile idiopathic arthritis Patients with juvenile idiopathic arthritis who are candidates for biologic disease-modifying antirheumatic drugs experience reductions in disease activity with ixekizumab.

#MedNews - Patients with juvenile idiopathic #arthritis who are candidates for biologic disease-modifying antirheumatic drugs experience reductions in disease activity with #ixekizumab.

Full story 👉 buff.ly/1BCUnZ2

#RheumSky #DMARDs

Figure 2 Survival at 24-month from randomization free of (A) renal flares, (B) extra-renal flares and (C) overall clinical flares in lupus nephritis patients presenting with asymptomatic serological reactivation and randomized to receive pre-emptive treatment (PT Group) or observant management (Control Group).

Interesting trial in @kidneyint@bsky.social

www.kidney-international.org/article/S008...

SLE with remission. No symptoms. When dsDNA becomes positive (or doubles) do you preemptively increase immunosuppression?

#NephSky #RheumSky

Immune reset and immune retune: approaching cure? - Nature Reviews Rheumatology The emergence of potent depletion therapies for the treatment of refractory autoimmunity has led to the concept of immune reset. Understanding whether immune reset equates to cure, and whether cure is...

✨ April Issue✨| Immune reset and immune retune: approaching cure?

In this Comment article, John Isaacs discusses whether immune reset equates to cure

bit.ly/4bD2zBS

#Rheumsky #Medsky

COPA syndrome spans multiple organs but is defined by STING in the lung - Nature Reviews Rheumatology A large European cohort clarifies COPA syndrome as a multi-organ interferonopathy defined by STING-driven interstitial lung disease (ILD). These findings refine diagnosis and treatment and establish C...

✨April Issue✨| COPA syndrome spans multiple organs but is defined by STING in the lung

This News & Views article discusses the findings from a large European COPA syndrome cohort

bit.ly/40J4OyB

#Rheumsky #Medsky

Advances in cartilage imaging techniques - Nature Reviews Rheumatology Non-invasive imaging of articular cartilage has evolved markedly and can be used to monitor response to treatment and predict disease outcomes. This Review provides rheumatologists with a comprehensiv...

✨April Issue✨| Advances in cartilage imaging techniques

This article provides a comprehensive update on current and emerging imaging and analysis techniques for assessing cartilage.

bit.ly/47QXrJd

#Rheumsky #Medsky

Metabolic masqueraders of paediatric and adult rheumatic diseases - Nature Reviews Rheumatology Inborn errors of metabolism are a diverse group of disorders that can mimic rheumatological disease, often presenting with progressive joint and systemic involvement. This Review serves as a primer fo...

✨ April Issue✨| Metabolic masqueraders of paediatric and adult rheumatic diseases

This Review explores the clinical aspects and mechanisms by which metabolic changes cause immune dysregulation.

bit.ly/4rH3es8

#Rheumsky #Medsky

Mechanisms of fibrotic tissue remodelling: insights from systemic sclerosis - Nature Reviews Rheumatology Systemic sclerosis (SSc) is a severe fibrotic disease that affects multiple organs, driven by vascular damage, inflammation and dysregulated repair. The authors of this Review explore the key mechanis...

✨April Issue✨| Mechanisms of fibrotic tissue remodelling

The authors discuss the mechanisms that mediate fibrotic tissue remodelling, using insights from SSc.

bit.ly/4bB1t9T

#Rheumsky #Medsky

Recommendations for the use of CLASI as an outcome measure in cutaneous lupus erythematosus clinical trials Nature Reviews Rheumatology - In this Expert Recommendation, a working group integrating diverse perspectives presents a comprehensive overview of the clinical relevance and applicability of the...

✨April Issue✨| Recommendations for the use of CLASI as an outcome measure in cutaneous lupus erythematosus clinical trials

These recommendations provide an overview of the clinical relevance and applicability of CLASI in CLE trials.

rdcu.be/e89qw

#Rheumsky #Medsky

mask on doctors desk

✨April Issue✨| Featuring articles on:

• Mechanisms of fibrotic tissue remodelling
• Metabolic masqueraders of rheumatic diseases
• Advances in cartilage imaging techniques
• Recommendations for the use of CLASI as an outcome measure in CLE

bit.ly/4dLpNZ9

#Rheumsky #Medsky

Correlation between clinical variables and disease activity

NEW RESEARCH—Development and validation of clinical criteria for the definition of disease activity in adult-onset Still's disease: a cohort study bit.ly/4rZwyKH

Plus, linked Comment bit.ly/4dgPYHf #Medsky #Rheumsky

Late onset axial spondyloarthritis presenting with fever of unknown origin. A case-based review The first report of late-onset axial spondyloarthritis presenting with fever of unknown origin. Physicians need to be aware of rare manifestations of ax-SpA in the elderly population.

#MedCase - The first report of late-onset axial #spondyloarthritis presenting with fever of unknown origin.

Physicians need to be aware of rare manifestations of ax-SpA in the elderly population.

👉 buff.ly/i1TChoN

#RheumSky #MedSky

Thrombo-inflammation and Rethinking the Role of Aspirin in Kawasaki Disease Cardiac and thrombotic problems are severe outcomes of Kawasaki disease. The standard therapy is intravenous immunoglobulin plus aspirin but the ideal aspirin dose is still controversial.

Cardiac and thrombotic problems are severe outcomes of #KawasakiDisease.

The standard therapy is intravenous immunoglobulin plus aspirin but the ideal aspirin dose is still controversial.

Find out more 👉 buff.ly/zojnCxj

#RheumSky

Obinutuzumab significantly reduces disease activity in SLE Adding the anti-CD20 monoclonal antibody obinutuzumab to standard therapy for systemic lupus erythematosus significantly reduces disease activity.

#MedNews - Adding the anti-CD20 monoclonal antibody #obinutuzumab to standard therapy for systemic lupus erythematosus significantly reduces disease activity.

Full story 👉 buff.ly/lbBXfea

#RheumSky #SLE