Lactylation of the SARS-CoV-2 spike protein is required for viral infection - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Lactylation of the SARS-CoV-2 spike protein is required for viral infection

This letter identifies #lactylation as a novel #PostTranslationalModification on the #SARSCoV2 S protein that enhances ACE2 and TMPRSS2 binding, promotes membrane fusion and #ViralEntry, while inhibition reduces infectivity.

#OpenAccess in #STTT:

⭐ NAR Breakthrough! ⭐
🦠 New study shows phage X1 hijacks Yersinia's enterocolitica flagellum to inject its DNA directly into the cytosol. Yersinia, though, strikes back!
🦠 A fascinating look at the #dualrole of #flagella in #viralentry and #bacterialimmunity.
🧬 Read more: doi.org/10.1093/nar/...

Discovery of vina-ginsenoside R18 as a novel dual-target inhibitor of dengue virus envelope protein and RNA-dependent RNA polymerase Vina-ginsenoside R18, acts as the first dual inhibitor of dengue virus E protein and RdRp, blocking viral entry and replication effectively

This study identifies Vina-ginsenoside R18, a #triterpenoid #saponin from #PanaxNotoginseng, as the first dual inhibitor of DENV E protein and RdRp, blocking #ViralEntry and replication, and effectively suppressing #dengue infection in vitro & in vivo.

#OpenAccess: amm-journal.org/index.php/20...

Why Certain GII.4 Norovirus Strains Enter Cells More Efficiently

A Baylor study found that GII.4 norovirus strains rely on capsid residues V333 and R339 to form cell‑surface clusters that trigger membrane repair pathways for entry. Read more: getnews.me/why-certain-gii-4-norovi... #norovirus #gii4 #viralentry

An antibody against PRCV and TGEV cross-neutralizes FCoV-23.
#SpikeProtein #ViralEntry #Coronavirus #CatHealth

This review explores the #Celegans-Orsay virus model, offering insights into the mechanisms of #ViralEntry, viral replication, immune evasion, and the release of new viral particles. #RNAi #medsky #AntiviralTherapy

Read: link.springer.com/article/10.1...