🧬 We discovered how bacteria detect phage infections by sensing fragments of their own degraded DNA.
Meet #ApeA – a #BacterialImmunity system activated by a novel signal - #Deoxydinucleotides.

Read our preprint: biorxiv.org/content/10.648
98/2026.01.26.701840v1

A thread 🧵 (1/11)

⭐ NAR Breakthrough! ⭐
🦠 New study shows phage X1 hijacks Yersinia's enterocolitica flagellum to inject its DNA directly into the cytosol. Yersinia, though, strikes back!
🦠 A fascinating look at the #dualrole of #flagella in #viralentry and #bacterialimmunity.
🧬 Read more: doi.org/10.1093/nar/...

🚀 From Bench to Paper | #Nature: Doudna lab discovers a minimal #Cas10 #enzyme (#mCpol) that defends bacteria via c-di-AMP-based inhibitory signalling.
🚨 When #c-di-AMP drops, cells self-destruct to block phage.
Research tool: c-di-AMP (MedChemExpress, HY-12326A)
#CRISPR #BacterialImmunity

🦠🧬 Bacteria's epic defense hack: Menshen system reveals molecular martial arts against phage invaders! Protein modules dance & shuffle in survival's ultimate game. 🥋 #Genomics #BacterialImmunity #ScienceBreakthrough https://emmecola.github.io/genomics-daily