In its final form, the paper has evolved vastly from the original preprint. We’ve removed thousands of words and added new functional data - including a deep dissection of the complex relationship between #IDRs and lysine #acetylation. (2/7)
This review examines lysine #crotonylation (Kcr) as a widespread #PostTranslationalModification regulating gene expression, #DNArepair, protein stability, and disease, highlighting crosstalk with #acetylation and other PTMs as therapeutic targets.
Read: doi.org/10.1016/j.ge...
8 days left to register | 28 invited speakers | Keynotes from F. Ulrich Hartl, Roland Beckmann and Michael Rapé | #chaperones #degradation #ubiquitin #cryoEM #acetylation #lipidation #ribosomes #proteins
proteintermini.org/meeting/
Person standing behind a lectern with a laptop, gesturing with one hand and holding a remote control in the other, next to a wall with the text 'Max-Planck-Institut für Immunbiologie und Epigenetik
Person standing behind a lectern with a laptop.
We had a super interesting seminar by Giacomo Cavalli (@cnrs.fr | @umontpellier.bsky.social), today. 🤩
… with exciting data and results by the Cavalli on epigenetic memory of past events that get mediated by Polycomb components & #histone #acetylation. Thanks to @iovino-lab.bsky.social for hosting!
Epigenetics Update - BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation bit.ly/497Jcj2
Bin Zheng and Ali Shilatifard reporting in Mol Cell
#Epigenetics #Acetylation #BRD2 #MOF
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High-resolution insights without cell sorting; epigenometech.com
Yohsuke T. Fukai, Kyogo Kawaguchi, et al. reconstituted gene-scale #chromatin arrays with controlled #histone modification patterns in vitro and showed that heterogeneous #acetylation alone can drive pattern-dependent changes in chromatin architecture and dynamics.
doi.org/10.1126/scia...
This study identifies HMGN2 as a key #Epigenetic regulator in enhancing #Glioma progression by stabilizing #H3K27ac #Acetylation at the CDC20 promoter, positioning the HMGN2/CDC20 axis as a potent target for #GliomaTherapy. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
Protein N-terminal acetylation regulates the growth of rice plants | #NAA30 #NatC #rice #acetylation www.sciencedirect.com/science/arti...
Two new volumes of Methods in Enzymology with 29 chapters/papers on Protein termini methods and reviews are now out! Thx to all authors!🙌 @ispt-proteinterm.bsky.social #N-degron #prenylation #myristoylation #formylation #arginylation #oxidation #acetylation www.sciencedirect.com/bookseries/m...
Ooh, this looks like fun! (And really useful) #acetylation
SIRT5 promotes the osteo-inductive potential of BMP9 by stabilizing the HIF-1α protein in mouse embryonic fibroblasts
This study reveals that the osteogenic potential of #BMP9 could be promoted by #Sirtuin5, potentially through stabilizing hypoxia-inducible factor 1 subunit alpha (#HIF1α), by reducing its #acetylation and malonylation modification. #medsky
#OpenAccess: www.sciencedirect.co...
A new paper from the lab of David Gius, MD, PhD, and supported by the Shock Center GeroMetabolism Core uses a novel mouse model targeting #mitochondrial #acetylation to identify potential functional mechanisms of ketogenic diets on lipid metabolism.
bit.ly/3FPl49W
The findings reveal that PRM2 is necessary for maintaining specific histone post-translational modifications, such as #acetylation, essential for proper #spermatogenesis and particularly for proper chromatin #remodelling.
#EditorChoice
🔗📚👇
academic.oup.com/molehr/artic...
In this study, using a Prm2-deficient mouse model and human sperm samples, the authors observed alterations in #methylation and #acetylation profiles of histones H3 and H4.
The N-terminal acetyltransferase Naa50 regulates ovule and embryo sac development in Arabidopsis. #N-terminal #acetylation @ispt-proteinterm.bsky.social link.springer.com/article/10.1...
Now online - the Feature Review "Protein N-terminal modifications: molecular machineries and biological implications" from @natmachinery.bsky.social and colleagues.
#Acetylation #Methylation #Myristoylation #Ubiquitylation #Oxidation #Arinylation
authors.elsevier.com/sd/article/S...
A whole universe of protein N-terminal modifications and their biological impact! Thanks to all co-authors! @cp-trendsbiochem.bsky.social @ispt-proteinterm.bsky.social #oxidation #acetylation #methylation #myristoylation #arginylation #ubiquitylation www.sciencedirect.com/science/arti...
A majority of eukaryotic proteins are N-terminally acetylated. Here is an updated review of the responsible enzymes and the impact of this modification for proteins, cells and organisms @naturecomms.bsky.social @ispt-proteinterm.bsky.social #acetylation #N-termini #N-degron rdcu.be/d6mbd
Visualization of stereocilia (cyan) and kinocilia (magenta) in the developing inner ear of zebrafish using anti-acetylated tubulin antibody (magenta), and phalloidin stain (cyan).
Zebrafish model with defective actin N-terminal acetylation uncovers hearing defects. From the cover of Life Science Alliance @embopress.bsky.social - image from @varshneylab.social @sheng-jia.bsky.social #zebrafish #PTMs #acetylation #cytoskeleton
www.life-science-alliance.org/content/7/12...
Not to be missed if you are in/around Cambridge next Monday.
#Chromatin #EpiSci #RNA #Transposons #Acetylation
