#BMP9 upregulates #SIRT5 to drive #osteogenic differentiation in #MSCs and promote #BoneDefect repair by reducing HIF‑1α acetylation/malonylation—expanding BMP9 mechanisms and identifying targets to boost #osteogenesis for #TissueEngineering.

#OpenAccess: doi.org/10.1016/j.ge...

This study uncovers the role of #BMP9 signaling in regulating #Odontoblast and HERS function, highlighting its importance in tooth root development and paving the way for future research on root regeneration and dental tissue repair. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This study demonstrates that #BMP9 regulates #Odontoblast differentiation & HERS activity to guide root development, highlighting it as a potential target for #ToothRoot regeneration. #DentalResearch #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

Using a mouse molar model, this study provides mechanistic insights into how #Bmp9 modulates #odontoblast differentiation, cell proliferation & intercellular junctions within the HERS during tooth root development. #Dentin #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

SIRT5 promotes the osteo-inductive potential of BMP9 by stabilizing the HIF-1α protein in mouse embryonic fibroblasts

This study reveals that the osteogenic potential of #BMP9 could be promoted by #Sirtuin5, potentially through stabilizing hypoxia-inducible factor 1 subunit alpha (#HIF1α), by reducing its #acetylation and malonylation modification. #medsky

#OpenAccess: www.sciencedirect.co...

Sonic Hedgehog potentiates BMP9-induced osteogenic differentiation of mesenchymal stem cells

This new research shows that co-administration of #BMP9 and Sonic Hedgehog (Shh) achieve more potent osteo-inductive effects in #MesenchymalStemCells, offering a promising strategy for the treatment of fracture nonunion, delayed #FractureHealing, and bone defects. #medsky

www.sciencedirect.co...

University of Pennsylvania | 14th International BMP Conference It is our great pleasure to welcome you to the 14th International Bone Morphogenetic Protein (BMP) Conference, held at the University of Pennsylvania's Smilow Center for Translational Research in Phil...

It is still possible to sign up for the conference on Bone Morphogenetic Proteins in May! 🧬🧶🧪🩸🔬👩‍🔬🦴🩺🤗 #BMP #activin #SMAD #ACVR1 #BMPR2 #BMP9 #ACVRL1
www.14thbmpconference2025.com

#BMP9 #MyocardialInfarction

BMP9 expressed by #EndothelialCell #CardiacFibroblast Not #Cardiomyocyte

BMP9 KO🐭post-MI->
⏬Survival
⏫TGFβ signal, #CardiacFibrosis, MMP9

How about #Angiogenesis/#EndMT?🧐

Navin Kapur lab #JACCBTS 2023
www.sciencedirect.com/science/arti...