STING drives pressure overload–induced #CardiacFibrosis and remodeling by promoting #inflammation, oxidative stress, and fibroblast activation, while #mitophagy limits cytosolic #mtDNA and STING signaling. #HeartFailure

#OpenAccess: doi.org/10.1016/j.ge...

Long non-coding RNA nonnmmut065573 (tentatively designated LncRNA-IH) activates the TGFβ−1 signaling pathway after myocardial infarction

Cell Regen Research | LncRNA-IH drives cardiac fibrosis after myocardial infarction!🫀🫀
Overexpression worsens remodeling & activates TGF-β1/ZEB1 in fibroblasts. #CardiacFibrosis #HeartFailure

🔗 Full paper at: doi.org/10.1186/s136...

Dietary nitrate and nitrite protect against doxorubicin-induced cardiac fibrosis and oxidative protein damage in tumor-bearing mice

➡️ buff.ly/RyGNFd5

#Nitrate #CardiacFibrosis #Nitrite

E3 ligase CHIP restoration facilitates the effect of α1-adrenoceptor blockage on alleviating lipopolysaccharide-caused cardiac fibrosis via downregulating TGF-BR1 expression and Smad2/3 activation - M... Myocardial fibrosis is a serious complication in sepsis and leads to cardiac dysfunction. The carboxy terminus of Hsc70-interacting protein (CHIP), a U-box E3 ligase, defends against sepsis-caused car...

#Research
E3 ligase #CHIP restoration facilitates the effect of α1-adrenoceptor blockage on alleviating #lipopolysaccharide-caused cardiac fibrosis via downregulating TGF-BR1 expression and Smad2/3 activation doi.org/10.1186/s435...

#Norepinephrine #CardiacFibrosis #Fibroblast

Supercentenarian gene variant, LAV-BPIFB4, protects the Hutchinson-Gilford #Progeria syndrome (HGPS) heart against #CardiacFibrosis and promotes #CellSurvival, thus preserving its diastolic function. #medsky @bristoluni.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

TET3 is a regulator and can be targeted for the intervention of myocardial fibrosis | EMBO Molecular Medicine imageimageActivation of quiescent fibroblasts contributes to adverse ventricular remodeling following myocardial injuries, leading to heart failure. The DNA demethylase TET3 trans-activates the mechan...

Epigenetics Update - TET3 is a regulator and can be targeted for the intervention of myocardial fibrosis bit.ly/489VzfD

#Epigenetics #DNADemthylation #HeartFailure #CardiacFibrosis #TET3

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Discover the breakthrough at epigenometech.com

Do not miss the
@ishr-es.bsky.social
#cardiacfibrosis webinar tomorrow! For some background reading:

Arantxa Gonzalez Miqueo
10.1042/CS20130538

Javier Barallobre-Barreiro
10.1161/CIRCULATIONAHA.111.056952

Sandrine Horman
10.1016/j.yjmcc.2016.01.001
10.1097/MOH.0000000000000820

👉 Remember to join our free #webinar on #cardiacfibrosis tomorrow, Tuesday 9/9 @ 12:00 CET.

🌟 Register via the QR code below, or at uio.zoom.us/webinar/regi...

This week: Drs. Sangkyun Cho, Siyeon Rhee, Joseph Wu, and a team at ‪@stanford.edu showed that the inhibition of stromal mechanosensing can suppress #CardiacFibrosis! 🫀

Read the article: go.nature.com/4mlc8d8
Listen to the discussion: bit.ly/3YJKixl

Key point: Cardiac alterations at structural and molecular levels were found in two epilepsy models with different mechanisms of induction.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #animalmodels #cardiacfibrosis #cardiachypertrophy #ionchannels #postSE

Mitophagy deficiency activates stimulator of interferon genes activation and aggravates pathogenetic cardiac remodeling

In this study, researchers show that #StimulatorofInterferonGenes (STING) contributes to #CardiacFibrosis, promotes adverse remodeling, and highlights STING as a potential therapeutic target for the prevention of #CardiacRemodeling induced by pressure overload. #medsky

#OpenAccess: buff.ly/CN3Dykn

Endothelial-to-Mesenchymal Transition in Cardiovascular Pathophysiology
#EndMT

#Atherosclerosis
#VascularCalcification
#PeripheralArteryDisease
#PulmonaryHypertension
#ValvularHeartDisease
#MyocardialInfarction
#CardiacFibrosis

Krishna Singh lab #IJMS_MDPI 2024
www.mdpi.com/1422-0067/25...

#SGLT2i #cardiAcfibrosis
suppresses
cardiac fibroblasts
#Empagliflozin #Dapagliflozin

#cardiosky

#BMP9 #MyocardialInfarction

BMP9 expressed by #EndothelialCell #CardiacFibroblast Not #Cardiomyocyte

BMP9 KO🐭post-MI->
⏬Survival
⏫TGFβ signal, #CardiacFibrosis, MMP9

How about #Angiogenesis/#EndMT?🧐

Navin Kapur lab #JACCBTS 2023
www.sciencedirect.com/science/arti...