#AortaEd
#Diabetes

⬆️HbA1c level (even in normal range) is associated with ⬇️asc/desc thoracic aortic diameter & ⬇️risk for Aneurysm/Dissection

Multi-omics #UKBiobank Mendelian Randomization analyses➡️a causal link b/w glycemic traits / #T2D & TAAD risk

#JACCBTS 2025
www.jacc.org/doi/10.1016/...

🩸 New #JACCBTS study reveals estrogen’s dual effects on microvascular health differ by sex

⚖️ A balanced ceramide: S1P ratio is 🔑 to endothelial health
🧬 May explain why long-term hormone exposure can 📈 CV risk

🔗 https://bit.ly/43Ct5In

#APSSexDiff2025 #CardioSky #MedSky

A workflow to optimize siRNA targeting SMILR #LncRNA & #SmoothMuscleCell proliferation/migration ex vivo

30 min siRNA exposure is sufficient to penetrate ~10 lamellar layers of explanted saphenous vein media

Polyethylenimine as siRNA delivery agent

#JACCBTS 2025
www.jacc.org/doi/10.1016/...

Obesity is a major risk factor for HFpEF. Join me in learning about a new HFpEF model that Valero-Munoz et al developed to study how adipose tissue changes in a 🐁 model and human patients🚶‍♂️in this month's #JACCBTS @jaccjournals.bsky.social . 🧵: 1/8

Using a robust preclinical rat model of HFpEF, Dr. Andrew Gibb and colleagues identified disruptions in mitochondrial function and metabolism as key contributors to HFpEF pathophysiology. Check out the research manuscript and accompanying editorial out now in #JACCBTS. #cardiosky

New #JACCBTS issue dives into the overlooked cardiohepatic axis, highlighting heart-liver crosstalk in metabolic syndrome, #heartfailure, and cirrhosis. Explore how this interplay is reshaping our understanding of heart health: www.jacc.org/toc/basic-tr... #CardioSky #MedSky

Balancing the risk for clotting and bleeding is constant challenge for cardiologists, so I was very excited to see in this month’s #JACCBTS work on targeting different parts of the coagulation cascade (Factor 11, FXI) to reduce bleeding risk while lowering risk for thrombosis. 🧵: 1/8

Delayed miR-199a Administration After Myocardial Infarction Precludes Pro-Regenerative Effects:

For clinical use, miR-199a-3p should be given early after #cvMI using non-viral delivery. Synthetic #miRNA mimics via lipofection show promise, but more research is needed. www.jacc.org/doi/10.1016/... #JACCBTS

Phenotype-Based Classification of Obstructive Hypertrophic Cardiomyopathy Undergoing Myectomy: Discover why JACC is the ultimate publishing partner for your cardiovascular research.

#JACCBTS study identified 3 subtypes of #oHCM in pts who underwent septal reduction therapy:
1️⃣ Sarcomere mutation–rich, thick IVS
2️⃣ LA enlargement, high #AFib burden
3️⃣ ⬆️#LVOT gradient, inflammation, ⬆️ postop events

Validated in 2 cohorts jacc.org/doi/10.1016/...

IL-6 Inhibitors and TNF Inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis

🏃‍♀️💉 In RA pts, 12 weeks of HIIT ⬆️ cMRI-based LVM (cardiac remodeling) in those on TNFi—but not in those on IL-6i.

Yet, IL-6i vs TNFi didn’t significantly alter overall exercise-induced LVM change. www.jacc.org/doi/10.1016/... #JACCBTS #Arthritis

Redirecting

9/9
In summary, IL-6 may play a beneficial role in cardiovascular adaptation, and this may impact cardiovascular adaptation to exercise in patients taking an IL-6 inhibitor for RA. Read the full paper in this month’s issue of #JACCBTS! doi.org/10.1016/j.ja...

Title page of a paper titled IL-6 inhibitors and TNF inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis

In this month’s issue of #JACCBTS, Jønck, et al. explore the effects of cytokine inhibitors on cardiovascular adaptability in rheumatoid arthritis (RA). Read below to see what they found! 🧵
1/9
@jaccjournals.bsky.social

Exciting news! 🎉

Matthias Nahrendorf, MD, PhD, has been named Editor-in-Chief of #JACCBTS! A leader in CV research, imaging & immunology, he brings a passion for collaboration & scientific excellence.

Please join us in welcoming him to this important role 👏👏 👏

📎: www.jacc.org/announcement...

Follow @michaelraddatz.bsky.social @jeffhsumd.bsky.social and @vascularimmuno.bsky.social and I for more updates on great science from #JACCBTS (🧵: 10/10)

I’ll always remember the first congestive hepatopathy patient I took care of as an intern @vumc.bsky.social. The pathology was so different from anything else, so when I saw an article on this in this month’s #JACCBTS I couldn’t wait to learn more about it. (🧵: 1/10) @jaccjournals.bsky.social

#CircularRNA #Atherosclerosis

CircBTBD7-encoded 420 aa peptide ⏬#SmoothMuscleCell proliferation migration
via binding to &⏫ubiquitin-proteasome degradation of SLC3A2

Lentiviral CircBTBD7-420aa⏬plaque size in🐭#Atherosclerosis

#JACCBTS 2025
www.sciencedirect.com/science/arti...

10/10
In summary, diseased AVICs have mitochondrial dysfunction, and spermidine supplementation or DNMT1 inhibition might hold promise as therapeutics to reverse this process and treat valve calcification. Read the full paper in this month’s issue of #JACCBTS! www.sciencedirect.com/science/arti...

Title page of a paper titled Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification

In these uncertain times, celebrating novel science is one way to stay grounded and hopeful. In this month’s issue of #JACCBTS, Song, et al. investigate mitochondrial function in aortic valve calcification. Join me to see what they found! 🧵
1/10

@jaccjournals.bsky.social

Recent Pathophysiological Insights Are Advancing Treatment of Venous Thromboembolism #VTE

#CardioSky #JACCBTS
www.jacc.org/doi/10.1016/...
@jaccjournals.bsky.social @gbarnesmd.bsky.social @heatherlgornik.bsky.social

follow @michaelraddatz.bsky.social, @jeffhsumd.bsky.social, and @vascularimmuno.bsky.social and I for more exciting science from #JACCBTS!

In summary, @spfisterer.bsky.social and co-authors created a semi-automated way to predict how variants in the LDLR gene will affect cholesterol and CVD risk, to tackle the ever-growing VUS problem! Read more in this month’s #JACCBTS! @jaccjournals.bsky.social 🧵:8/8

Great summary of new #JACCBTS study on #LongCOVID inflammatory platelet activation

From STAR UCLA cardiology fellow & @jaccjournals.bsky.social SoMe Coordinator @michaelraddatz.bsky.social #bruinhearts

👇🏼

9/9
In summary, CRP-rich plasma from Long COVID patients ⬆️ platelet activation, and platelet activation correlates with the severity of 🫁 damage. Platelet activation is reversible with aspirin or P2Y12. Read the paper in this month’s issue of #JACCBTS! doi.org/10.1016/j.ja...

Platelet and Endothelial Activation as Potential Mechanisms Behind the Thrombotic Complications of COVID-19 Patients: Discover why JACC is the ultimate publishing partner for your cardiovascular research.

2/
The authors previously showed in #JACCBTS that post-COVID pts have ⬆️ platelet activation: www.jacc.org/doi/10.1016/.... However, they looked to test this in Long COVID syndrome. Long COVID patients in this study were those who continued to have symptoms 6 mos post-infection. 🤒

Title page of paper entitled "Low-Grade Inflammation in Long COVID Syndrome Sustains a Persistent Platelet Activation Associated With Lung Impairment"

In this month’s issue of #JACCBTS, Brambilla, et al. explore the role of platelet function in long COVID. Read below ⬇️ to see what they found! 🧵
1/n
@jeffhsumd.bsky.social @jaccjournals.bsky.social @vascularimmuno.bsky.social @jeanwassenaar.bsky.social

Interesting study from Peter Stone group showing WSS Metrics Associate With Proinflammatory Pathways at Culprit Site of Coronary Erosion

#JACCBTS #CardioSky
@jaccjournals.bsky.social @accintouch.bsky.social
www.jacc.org/doi/10.1016/...

Stay connected & share your insights with the JACC Journals community by using our hashtags & tagging @jaccjournals.bsky.social:
📖 #JACC
🌟 #JACCAdvances
🌏 #JACCAsia
🔬 #JACCBTS
💙 #JACCCardioOnc
🩺 #JACCCaseReports
⚡️ #JACCCEP
❤️ #JACCHF
🩻 #JACCIMG
🚀 #JACCINT
📚 #JACCJournals
🎧 #JACCPodcast
💡 #JACCEdge

#NitricOxide Releasing Nanomaterials for Cardiovascular Applications

NO donor-coated Stents or -loaded Vascular grafts to facilitate (re)endothelization & to quench restenosis

No-releasing nanoparticles for Myocardial I/R injury

#JACCBTS 2024
www.sciencedirect.com/science/arti...

Detailed planning of AAV9 intramuscular injection in ischemis🐭limb

AAV9-IGF1⏫myogenesis in🐭#LimbIschemia, w/o impacting satellite cell self-renewal or #Angiogenesis

Interesting myogenesis-angiogenesis decoupling!🤓

Terence Ryan lab #JACCBTS 2023
www.sciencedirect.com/science/arti...

Palmdelphin, a risk gene for #CalcficAorticValveDisease & highly enriched in #ValvularEndothelium,
protects against #HighFatDiet-induced decline of Aortic Valve Structure+Function

Palmdelphin binds to TNIP1/GDF15/JAK1 ➡️ TNF & NFκB signals

#JACCBTS 2023
www.sciencedirect.com/science/arti...