Reveal novel regulatory transcripts with Novogene lncRNA-seq. We provide high-accuracy identification, quantification, differential expression & target prediction using strand-specific libraries and robust bioinformatics. #lncRNA #Transcriptomics #RNAseq https://tinyurl.com/2s8nmxby

Gene Expression Profile Identifies LncRNA AL355974.3 As a Potential Glioma Biomarker

This study investigates #lncRNA expression in #Glioma tissue, functions of differentially expressed lncRNAs, their roles in #Tumor progression, & their potential to inform future research to identify #Biomarkers for diagnosis and treatment. #medsky

To read: doi.org/10.1007/s115...

In the cytoplasm of neuroblastoma cells, PTBP1 maintains CyCoNP homeostasis by modulating miR-4492 loading, sustaining NCAM1 expression. PTBP1 loss enhances miRNA repression over CyCoNP #lncRNA bit.ly/3Mrgx1k

Re-engineering long noncoding RNA (lncRNA) from the human transcriptome as exogenous drugs capable of treating disease.

Exciting news! We created the first therapeutics from the dark transcriptome & are featured as the cover article in Science Signaling! We chemically synthesized & optimized #lncRNA from the dark transcriptome & used them as exogenous drugs to treat disease. #medsky #scisky #science lnkd.in/dpNEaJ8j

Scientists show #lncRNA AC004854.2 drives #ColorectalCancer by disrupting the PUF60–FUBP1 complex to boost #cMYC transcription; forming a SOX4/AC004854.2/PUF60/c-MYC axis that promotes #tumor growth, attenuated by c-MYC inhibition.

#OpenAccess: doi.org/10.1016/j.ge...

LncRNA NPTN-IT1-201 Ameliorates Depressive-like Behavior by Targeting miR-142-5p and Regulating Inflammation and Apoptosis via BDNF

This study finds that #lncRNA NPTN IT1 201 sponges #miR 142 5p, upregulates BDNF, reduces #Inflammation, #Apoptosis, & #Microglial activation, helping to alleviate depressive-like behavior, promising a potential #therapeutic target for MDD. #medsky

To read: doi.org/10.1007/s115...

#FruitRes
Study uncovers lncRNA networks regulated by MdHYL1 in apple, linking miRNA mimicry to leaf development, lignin & water transport.
Details: maxapress.com/article/doi/10.48130/fru...
#Apple #lncRNA

Wee1-AS, a #lncRNA, protects against #MASLD by repressing #Wee1 and stabilizing #CYCLINB1 to activate CDK1-driven mitochondrial #FattyAcidOxidation, while WEE1 inhibition or the human homolog LNC106435.1 similarly improves mitochondrial function.

#STTT: doi.org/10.1038/s413...

Overexpression of Long Non‑Coding Rnas Mcm3ap‑As1 and Linc00092 Predict Poor Prognosis in Patients With Gastric Adenocarcinoma LINC00092 & MCM3AP‑AS1 overexpression linked to gastric cancer severity. They may serve as prognostic markers. What does this mean for treatment strategies? #GastricCancer #LncRNA

LINC00092 & MCM3AP‑AS1 overexpression linked to gastric cancer severity. They may serve as prognostic markers. What does this mean for treatment strategies? #GastricCancer #LncRNA
www.rimpacts.com/rd/p?c=10167... 📄DOI: doi.org/10.4103/abr....

LncRNA MEG3 Inhibits the Epithelial-mesenchymal Transition of Bladder Cancer Cells through the Snail/E-cadherin Axis

MEG3, a #lncRNA, suppresses #EpithelialMesenchymalTransition in #BladderCancer by binding Snail to prevent #Ecadherin repression and inhibiting ERK/JNK/P38 signaling, reducing invasion and migration—highlighting its promise as a therapeutic target.

Read: doi.org/10.1007/s115...

This study reveals that #CREB1-induced #lncRNA LOC100270746 facilitates #GastricCancer progression through a DDX5/mTOR-dependent mechanism, establishing it as a promising #Biomarker and #TherapeuticTarget.

#OpenAccess: doi.org/10.1016/j.ge...

New study by Zhang et al. identifies four long non-coding RNAs in blood as promising biomarkers for diagnosing major depression and predicting treatment response. doi.org/10.1016/j.ne... #Depression #Biomarkers #lncRNA #MentalHealth #Neuroscience #Research #Psychiatry #RNA #MDD #MedSky #neuroskyence

Watch Novogene's free, on-demand webinar: Exploring the Untranslated: RNA Sequencing Basics & the Power of lncRNA. Learn library prep, sequencing strategies & downstream lncRNA analyses. #Transcriptomics #lncRNA #RNAseq https://bit.ly/3HB1peU

Postdoctoral Researcher in biology of long nong coding RNAs in macrophages Do you want to contribute to top quality medical The labs of Harald Lund and Alastair Kerr are seeking a postdoctoral fellow for an interdisciplinary project investigating the role of long noncoding R

📣 Postdoc opportunity
We're looking for a postdoc to study lncRNAs in tissue-resident macrophages — an interdisciplinary project between my lab and Alastair Kerr's lab at Karolinska Institutet

Apply here: ki.varbi.com/en/what:job/...
Deadline 8 Feb
#Postdoc #lncRNA #Macrophages #Immunology @ki.se

Reveal novel regulatory transcripts with Novogene lncRNA-seq. We provide high-accuracy identification, quantification, differential expression & target prediction using strand-specific libraries and robust bioinformatics. #lncRNA #Transcriptomics #RNAseq https://bit.ly/3DpuzLZ

Structural basis of long non-coding RNA PVT1 interactions with select mRNAs universal in pan-cancer system: A computational study PVT1 lncRNA can regulate multi-gene expression through diverse mechanisms, one of which is through binding interactions with mRNAs. Our previous study…

Thrilled to announce the publication of our latest research:
www.sciencedirect.com/science/arti...

This entails secondary structural studies on the probable mechanisms of PVT1 binding to multiple mRNAs, common DE coding & non-coding genes across pan-cancer system.
#lncRNA
#RNA
#CancerResearch

The #lncRNA Wee1-AS regulates mitochondrial #FattyAcidOxidation and alleviates #MASLD via CDK1/CYCLIN B1 activation, with mouse and human homolog data supporting therapeutic potential and highlighting a targetable Wee1-AS/WEE1 metabolic axis.

#STTT: doi.org/10.1038/s413...

lncRNAs shape molecular mechanisms, serve as biomarkers, and offer new therapeutic avenues in AKI and CKD.
#lncRNA #AKI #CKD #Biomarkers #KidneyDisease #MolecularMedicine
www.sciencedirect.com/science/arti...

New bladder cancer research: lncRNA FENDRR is a promising biomarker & therapeutic target, inhibiting progression through the miR-18a-5p/ESR1 axis. Low FENDRR = poor prognosis.

www.dl.begellhouse.com/journals/0ff...

#BladderCancer #lncRNA #CancerBiomarkers

#lncRNA USP30‑AS1 is identified as an #oncogenic driver in #BreastCancer, driving #tumor growth by repressing p21 through HnRNPF‑mediated mRNA destabilization & EZH2–c‑Myc activation, underscoring USP30‑AS1 as a #TherapeuticTarget. @tsinghua_uni

#OpenAccess: doi.org/10.1016/j.ge...

LINC00862 functions as a #tumor‑suppressive #lncRNA in #HepatocellularCarcinoma, regulating RBM47 through #CHD5‑mediated transcriptional activation & forming a positive feedback loop, underscoring its promise as a prognostic #biomarker in HCC.

#OpenAccess: doi.org/10.1016/j.ge...

#VegetableRes
Two novel lncRNAs from Chinese cabbage boost heat and drought tolerance in Arabidopsis, increasing survival rates and stress-responsive gene expression.
Details: maxapress.com/article/doi/10.48130/veg...
#lncRNA #StressTolerance

Discover the significance of long non-coding RNAs with Novogene’s lncRNA sequencing services. Gain insights into gene regulation and disease mechanisms.

Learn more: https://bit.ly/3DpuzLZ

#lncRNA #LongNonCodingRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation

#LncRNA #Autophagy #Atherosclerosis

ASO against CARMN, Smooth Muscle Cell-specific LncRNA, in Apoe-/-🐭
⏫Lesion burden
⏫BODIPY+ foam cell-like SMCs
⏬Lesion #Autophagy

Casein Kinase 1α, directly bound to CARMN⏩
AKT-ATG7-Lipophagy-Cholesterol efflux

#CellDeathDis 2025
www.nature.com/articles/s41...

Decreased M6A Modification Promotes Progression of Gastrointestinal Stromal Tumor and KIT‐Derived Imatinib Resistance Through FTO‐Regulated Axis The study identifies decreased m6A levels, FTO and lncRNA XIST as critical oncogenic molecules in gastrointestinal stromal tumor (GIST) progression and imatinib resistance, both in vitro and in vivo....

#Article in #MedComm_Oncology
Decreased M6A Modification Promotes Progression of Gastrointestinal Stromal Tumor and KIT-Derived #Imatinib Resistance Through FTO-Regulated Axis doi.org/10.1002/mog2...

#GIST #XIST #KIT #DrugResistance #N6_methyladenosine #FTO #lncRNA

#Article in #MedComm_Oncology

LncRNA SNHG5/miR-363-3p/USP28 Axis Promotes Lung Adenocarcinoma Progression Through Enhancing β-Catenin Stabilization doi.org/10.1002/mog2...

#lncRNA #LUAD #miR_363_3p #SNHG5 #USP28 #β_catenin #SingalingPathway

Discover how lncRNAs influence gene expression in our on-demand webinar: "Exploring the Untranslated." Learn the basics of lncRNA-seq and its research applications.

Watch now: https://bit.ly/3HB1peU

#lncRNA #RNASequencing #Transcriptomics #GeneRegulation #Innovation

New breast cancer study from our lab: using topological data analysis, researchers in our lab discovered that the lncRNA PURPL is a strong prognostic biomarker for Luminal A breast cancer.
doi.org/10.1101/2025...
#BreastCancer #CancerResearch #Oncology #Genomics #Biomarkers #TDA #lncRNA #Science

This review examines the impact of #Epigenetic modifications on #lncRNA transcription in #HepatocellularCarcinoma (HCC) and outlines the mechanisms of lncRNAs driving HCC development and progression. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Assembly of cancer-specific ribosomes by the lncRNA LISRR suppresses melanoma anti-tumour immunity Original paper: [LINK] Video summary by Eleonora Leucci (KU Leuven) Cinque et al. demonstrate that inhibition of a cancer-specific transcript makes human drug-tolerant persister cells visible to…

The assembly of cancer-specific #ribosomes by the #lncRNA LISRR suppresses #melanoma anti-tumour immunity, say Sonia Cinque, Yvessa Verheyden, Sara Adnane, Eleonora Leucci @leuccilrcb.bsky.social et al. (KU Leuven): rupress.org/jem/article/...

🎥 Video summary by Leucci: youtu.be/AKSuTne83jQ