The @martinfuhrmann.bsky.social Lab ( #DZNE) at #BonnBrain26:

#Microglial Ca-dynamics (Eyberg, A44)
NE-modulated #microglia (Antony, A45)
#Stress-driven #synapse remodeling (Crux, A46)
#Actin control of microglia (Hoffmann, A47)
#Odor coding in #SNNs (myself, A11)

Stop by our posters today 👌

LncRNA NPTN-IT1-201 Ameliorates Depressive-like Behavior by Targeting miR-142-5p and Regulating Inflammation and Apoptosis via BDNF

This study finds that #lncRNA NPTN IT1 201 sponges #miR 142 5p, upregulates BDNF, reduces #Inflammation, #Apoptosis, & #Microglial activation, helping to alleviate depressive-like behavior, promising a potential #therapeutic target for MDD. #medsky

To read: doi.org/10.1007/s115...

Verity F. T. Mitchener, Millie J. Thackray and I. Lorena Arancibia-Cárcamo from @crick.ac.uk discuss the glia-immune network, examining astrocytes and #oligodendrocytes as #microglial co-ordinators in health and disease 🔍️ 🔃

🔗 Read the #review here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

A cartoon showing a middle-aged mouse at an office desk, remembering (in a thought bubble) a childhood birthday, with his parent bringing him a cake with a single candle; cartoon glial cells are controlling a cable that links to his early memories. Infantile amnesia is the global loss of episodic and contextual memories formed in early life. Image credit: Birte Doludda

Infantile #amnesia limits our recall of early-life memories, but what is its cellular basis? @tjryan.bsky.social &co reveal that transient #microglial activity during postnatal development regulates infant #memory persistence & retrieval in mice @plosbiology.org 🧪 plos.io/4a0SoGH

A cartoon showing a middle-aged mouse at an office desk, remembering (in a thought bubble) a childhood birthday, with his parent bringing him a cake with a single candle; cartoon glial cells are controlling a cable that links to his early memories. Infantile amnesia is the global loss of episodic and contextual memories formed in early life. Image credit: Birte Doludda

Infantile #amnesia limits our recall of early-life memories, but what is its cellular basis? @tjryan.bsky.social &co reveal that transient #microglial activity during postnatal development regulates infant #memory persistence & retrieval in mice @plosbiology.org 🧪 plos.io/4a0SoGH

A cartoon showing a middle-aged mouse at an office desk, remembering (in a thought bubble) a childhood birthday, with his parent bringing him a cake with a single candle; cartoon glial cells are controlling a cable that links to his early memories. Infantile amnesia is the global loss of episodic and contextual memories formed in early life. Image credit: Birte Doludda

Infantile #amnesia limits our recall of early-life memories, but what is its cellular basis? @tjryan.bsky.social &co reveal that transient #microglial activity during postnatal development regulates infant #memory persistence & retrieval in mice @plosbiology.org 🧪 plos.io/4a0SoGH

www.sciencedirect.com/science/arti...

pmc.ncbi.nlm.nih.gov/articles/PMC...

pmc.ncbi.nlm.nih.gov/articles/PMC....

www.sciencedirect.com/ai?q=How+Non...
In ASD, #microglial activation & dysfunction have been consistently observed in both animal models and human studies

Product Citation 🦋

The FAM49B gene is downregulated in the normal aging process & in #PD pathology. StressMarq's #AlphaSynuclein PFFs helped to reveal that decreased FAM49B levels disrupt key #microglial functions.

Paper 🌼 https://go.nature.com/491OZIh
PFFs 🌺 https://bit.ly/2u9YHV2

#RepeatedMildClosedHeadInjury triggers sustained #neuroimmune and complement activation—marked by #microglial recruitment and #CognitiveImpairment—while post-injury #ComplementInhibition significantly mitigates these pathological changes.

#CoverPage in #STTT: doi.org/10.1038/s413...

Activation of the cGAS–STING pathway drives #RetinalInflammation in #endotoxin-induced #uveitis, while genetic deletion of #cGAS reduces #vitreous inflammation, vascular leakage, and #microglial activation. @fudan-university.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...

#RepeatedMildClosedHeadInjury activates complement-driven neuroimmune responses, induces #microglial dysfunction and #neurodegenerative pathways, and post-injury #ComplementInhibition can reverse these effects,

#OpenAccess in #STTT: doi.org/10.1038/s413...

We were delighted to host Prof Delphine Boche ( #SouthamptonUni) for our #SHiMR_NTU Seminar! She shared insights into #neuroinflammation in #Alzheimer’s disease and innovative methods to study #microglial cells in the human brain. Thanks to Dr Shreyasi Chatterjee for hosting! @ntuneuro.bsky.social

🔍We mapped enzyme “
#Checkpoints” at single-cell resolution!
📌 #Microglial & #Endothelial hotspots=key regulators!
💡 Found #Sex-specific timing windows & microbial levers that can tilt #Kynurenine away from toxicity and toward protection.
@mdpiopenaccess.bsky.social
👉 www.mdpi.com/2227-9059/13...

IT'S HERE ➡️ The first #MSNseminars of the new academic year! On Fri, Oct 17, 3pm, JOIN hosts @veronikakondev.bsky.social & Emily Birnbaum as @weillcornell.bsky.social's Sarah Naguib presents “Harnessing #Microglial #Resilience: genetic & therapeutic strategies across #Alzheimers, FTD & #Parkinsons".

- The chronic inflammation & elevated NETosis damage the endothelium, leading to a "leaky" BBB. Allows inflammatory factors & activated neutrophils to infiltrate CNS
- Neutrophils release NETs and other cytotoxic molecules directly within 🧠 , promoting neuroinflammation & #microglial activation.

Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience A single-cell epigenomic and transcriptomic atlas across six brain regions in Alzheimer’s disease reveals widespread epigenomic relaxation and information loss, associated with the selective depletion...

Groundbreaking new paper on #Alzheimers disease: researchers found widespread "epigenome erosion" that is linked to cell-type-specific and region-specific changes that correspond with #microglial cell shifts, cognitive decline, and even cognitive resilience!

www.cell.com/cell/fulltex...

Microglial STING is a central safeguard against neurological decline with age Immune pathways and cell types that protect against neurodegenerative processes with aging remain poorly understood. Sulka et al. demonstrate that the innate immune adaptor, STING, provides essential ...

#STING limits #inflammation and damage to DNA. Deficiency→ increased neurological decline via blood-brain barrier breakdown. #Microglial STING signaling critical to prevent BBB breakdown and ensure neuromotor deficits in the aging brain. bit.ly/4p9lkDc bit.ly/462sobK [open access].

β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity - Molecular Neurodegeneration To define how Aβ pathology alters microglia function in Alzheimer’s disease, we profiled the microglia surfaceome following treatment with Aβ fibrils. Our findings reveal that Aβ-associated human micr...

β-Amyloid induces #microglial expression of GPC4 and #APOE leading to increased neuronal tau pathology and toxicity

Brandon B. Holmes, Thaddeus K. Weigel, Jesseca M. Chung...James A. Wells #AlzheimersDisease #drosophila #amyloid #microglia @ucsanfrancisco.bsky.social

bit.ly/3HXP98J

'Early intervention anti-Aβ #immunotherapy attenuates #microglial activation without inducing exhaustion at residual plaques'

Lis de Weerd @lisdeweerd.bsky.social Selina Hummel, Stephan A. Müller...Christian Haass @haasslab.bsky.social #AlzheimersDisease #amyloid

bit.ly/3V8PDMa

Excited to be back at #AAIC2025! We already had a great start with an inspiring Imaging day yesterday. On Monday, I’ll present our work on how #microglial reactivity influences very early #amyloid accumulation on #PET. Come by poster 364 if you’d like to know more!

N6-methyladenosine RNA modification regulates microglial phagocytosis in the APP/PS1 mouse model of Alzheimer’s disease - Genes & Immunity Genes & Immunity - N6-methyladenosine RNA modification regulates microglial phagocytosis in the APP/PS1 mouse model of Alzheimer’s disease

N6 #methyladenosine #RNA modification regulates #microglial #phagocytosis in the #APP/PS1 #mouse model of #Alzheimer #disease

#Genes & #Immunity @springernature.com
www.nature.com/articles/s41...

Cell Press: STAR Protocols STAR Protocols is an open access, peer-reviewed journal from Cell Press. We offer structured, transparent, accessible, and repeatable step-by-step experimental and computational protocols from all are...

In vitro assay for #microglial #engulfment and #degradation of #synaptosomes in fixed and live samples, using #confocal imaging. Curious how it works? Check out our article (@ACCompagnion and @paolicellilab.bsky.social) in @cp-starprotocols.bsky.social.

star-protocols.cell.com/protocols/4321

The @sierralab.bsky.social lab is hiring!

Postdoctoral position in #microglial development (#IKUR)

www.achucarro.org/job/postdoct...

STING deletion protects against amyloid β–induced Alzheimer's disease pathogenesis INTRODUCTION While immune dysfunction has been increasingly linked to Alzheimer's disease (AD) progression, many major innate immune signaling molecules have yet to be explored in AD pathogenesis us...

By #genetically removing STING in mice, researchers saw significant improvements such as better control of harmful #amyloid #plaques, healthier #microglial activity, and protection against #cognitive decline.

GENEWIZ is honored to be cited in this study, providing #RNAseq: hubs.ly/Q03sPs0B0

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice CAR T cell therapy can cause cognitive impairment in mouse models with central nervous system (CNS) and non-CNS cancers by inducing persistent neuroinflammation, thereby disrupting oligodendroglial ho...

#CAR T cell therapy →white matter #microglial reactivity, chemokine expression → neurological #inflammation→ↆ #cognition in vivo. bit.ly/4kekKRI go.nature.com/3FpFp5Z

Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model - Molecular Neurodegeneration Background The epoxyeicosatrienoic acids (EETs) are derivatives of the arachidonic acid metabolism with anti-inflammatory activities. However, their efficacy is limited due to the rapid hydrolysis by ...

'Inhibition of soluble epoxide hydrolase confers #neuroprotection and restores #microglial homeostasis in a #tauopathy mouse model'

Shuo Wang, Chuangye Qi, Chetan Rajpurohit...Hui Zheng
@bcmhouston.bsky.social #AlzheimersDisease #microglia

bit.ly/42s0bdW

Our morning concluded with a few more trainee talks and another keynote speaker, Dr. Beth Stevens. #microglial #CNS #inflammation #aging

Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease - Nature Medicine Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passively and actively immunized patients with Alzheimer’s disease.

In this study, Lynn van Olst, Brooke Simonton, Alex Edwards, David Gate, et al. "uncover distinct #Microglial phenotypes in Aβ-immunized #AlzheimersDisease brains & reveal genes that control clearance of Aβ by microglia." Learn More @natmedicine.bsky.social www.nature.com/articles/s41...

Join us Wed. Feb 12th at 4pm CT for our Spring Seminar Series. Kimberley Bruce, PhD presents: "Targeting #Microglial #Metabolism in #Neurodegenerative Disease."

More info: bit.ly/4jjeaJw
#barshopseminarseries

APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology - Molecular Neurodegeneration Background Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD). A recent case report identified a rare variant in APOE, APOE3-R136S (Christchurch...

'#APOE Christchurch enhances a disease-associated #microglial response to #plaque but suppresses response to tau pathology'
bit.ly/4h7SUoG