We also found synapse loss and ghost tangle-like structures in affected neurons, as well as nuclear lamina deformations linked to microtubule defects. These hallmarks mirror what is observed in patient brains with #Tauopathy. 8/10

We combined 3R/4R #Tau expression with two synergistic Tauopathy mutations, P301L and S320F, that promote both nucleation and elongation of Tau fibrils. Neither 4R expression nor the mutations alone induced pathology. Only the combination triggered robust #Tauopathy. 4/10

🧵New paper from the lab @isd-research.bsky.social @lmu-klinikum.bsky.social @lmu.de in STM @science.org! A human #iPSC-derived #Tauopathy model that endogenously develops late-stage Tau pathology. Free personal PDF: www.science.org/eprint/5H5YD....
Here's what we found👇 1/10

Conformation-specific monoclonal antibodies reveal early Tau structural intermediates in Alzheimer’s disease Tauopathy, including Alzheimer’s disease, is the most prevalent neurodegenerative disorder, yet current therapies fail to halt disease progression, partly because of limited understanding of early tau...

Early-stage Tau folding may be the trigger for Alzheimer's aggregation. A new study tracks structural changes before fibrils even form. rPeptide's Tau-441 (Cat# T-1001) supported the research 🧬🧠

t.ly/60OGC

#Alzheimers #Neuroscience #TauProtein #Tauopathy #rPeptide

Female-specific Cx3cr1-driven regulation of #ALS and #Alzheimer’s risk genes in #tauopathy

Ari Sudwarts & Gopal Thinakaran @thinakaran.bsky.social #microglia #transcriptome

link.springer.com/article/10.1...

Peripheral #amylin synergizes with #diabetes to impair lysosomal function, elevate #pTau in the #brain and pancreas, and accelerate #tauopathy, highlighting a pancreas–brain axis linking metabolic dysfunction to #neurodegeneration.

#OpenAccess: doi.org/10.1016/j.ge...

Spilling the T: #Tcells in #tauopathy mechanisms, disease progression, and therapeutic horizons

Megan E. Bosch & Jason D. Ulrich

link.springer.com/article/10.1...

PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Regulating acetyl-CoA levels through Acetyl-CoA Synthetase 2 emerges as potential safeguard for #CognitiveFunction www.pnas.org/doi/10.1073/... #ACSS2 #Neurodegeneration #Tauopathy #TranslationalScience

🧠 ApoE4 lowers the p-tau217 #tauopathy threshold.
In two independent cohorts spanning preclinical and symptomatic #Alzheimer’s disease, the study tested where #ApoE4 accelerates the amyloid-to-tau transition.

🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

Product Citation ⭐

Researchers developed a multi-approach study to examine #proteostasis pathways involved in #tauopathy. Validation assays using StressMarq’s #Tau PFFs revealed NINL as a novel regulator of tau aggregation.

Paper 🌾 https://bit.ly/4szkrFE
Product 🍃 https://bit.ly/2JGrCaQ

DAP12 deletion reduces neuronal SLIT2 and #demyelination and enhances brain resilience in female #tauopathy mice

Hao Chen, Li Fan, Qi Guo...Li Gan & Wenjie Luo @liganlab.bsky.social @weillcornell.bsky.social #AlzheimersDisease

link.springer.com/article/10.1...

A diverse screening classifies unique categories of plant-based compounds that counteract tau-related disorders. #Tauopathy #NaturalProducts
www.life-science-alliance.org/content/9/2/...

Death-associated protein kinase 1-dependent SENP1 degradation increases tau #SUMOylation and leads to cognitive dysfunction in a mouse model for #tauopathy

Xindong Shui...Dongmei Chen, Tao Zhang, Tae Ho Lee #AlzheimersDisease

molecularneurodegeneration.biomedcentral.com/articles/10....

ICYMI: Read the latest #neuroscience research in JEM! The collection highlights the latest discoveries in meningeal #lymphatics, #pain, #neurodegeneration, #tauopathy, and #MultipleSclerosis. 👉 rupress.org/jem/collecti...

#SfN25

Human Tau (K18) Wild-Type Monomers (SPR-524) Order Human Tau (K18) Wild-Type Monomers (SPR-524) from StressMarq. High-quality reagents for neurodegenerative disease research.

New Product!💡

StressMarq now produces Tau (K18) Wild-Type Monomers, optimized for #tauopathy research. These monomers readily form fibrils when incubated with heparin or seeded with PFFs, enabling precise modeling of disease mechanisms.

View the product details 🔬 https://bit.ly/3JHYGl8

Newly discovered RNA molecule could limit protein aggregation and prevent neuronal damage Neurodegenerative diseases, such as Alzheimer's disease and dementia, are medical conditions that entail the progressive loss of neurons and a decline in brain function. Past studies have found a link...

MedicalXpress highlights our new #MolecularPsychiatry paper on lncRNA FAM151B-DT, a key regulator of tau and α-synuclein aggregation. #Neurodegeneration #Tauopathy #Alzheimers #Parkinsons

medicalxpress.com/news/2025-11...

Human Tau (K18) Wild-Type Monomers (SPR-524) Order Human Tau (K18) Wild-Type Monomers (SPR-524) from StressMarq. High-quality reagents for neurodegenerative disease research.

New Product!💡

StressMarq now produces Tau (K18) Wild-Type Monomers, optimized for #tauopathy research. These monomers readily form fibrils when incubated with heparin or seeded with PFFs, enabling precise modeling of disease mechanisms.

View the product details 🔬 https://bit.ly/3JHYGl8

🧠 Read our new #Neuroscience collection of research articles and reviews to accompany #SfN25 @sfn.org! Explore the latest discoveries in #neuroscience, including meningeal #lymphatics, #pain, #neurodegeneration, #tauopathy, and #MultipleSclerosis. 👉 rupress.org/jem/collecti...

🧠 Read @jem.org's #Neuroscience collection of research articles and reviews to accompany #SfN25 @sfn.org! Explore the latest discoveries in #neuroscience, including meningeal #lymphatics, #pain, #neurodegeneration, #tauopathy, and #MultipleSclerosis. 👉 rupress.org/jem/collecti...

Human Tau (K18) Wild-Type Monomers (SPR-524) Order Human Tau (K18) Wild-Type Monomers (SPR-524) from StressMarq. High-quality reagents for neurodegenerative disease research.

New Product!💡

StressMarq now produces Tau (K18) Wild-Type Monomers, optimized for #tauopathy research. These monomers readily form fibrils when incubated with heparin or seeded with PFFs, enabling precise modeling of disease mechanisms.

View the product details 🔬 https://bit.ly/3JHYGl8

Human Tau (K18) P301L Mutant PFFs (SPR-523) Order Human Tau (K18) P301L Mutant PFFs (SPR-523) from StressMarq. High-quality reagents for neurodegenerative disease research.

⭐New Product!⭐

StressMarq now provides Human Tau (K18) P301L Mutant Pre-formed Fibrils generated without heparin, offering an improved model for #tauopathy and #neurodegeneration studies. These PFFs induce neurotoxicity in primary mouse cortical neurons.

🔬Learn more here: http://bit.ly/46UZ4V1

Human Tau (K18) P301L Mutant PFFs (SPR-523) Order Human Tau (K18) P301L Mutant PFFs (SPR-523) from StressMarq. High-quality reagents for neurodegenerative disease research.

⭐New Product!⭐

StressMarq now provides Human Tau (K18) P301L Mutant Pre-formed Fibrils generated without heparin, offering an improved model for #tauopathy and #neurodegeneration studies. These PFFs induce neurotoxicity in primary mouse cortical neurons.

🔬Learn more here: http://bit.ly/46UZ4V1

Human Tau (K18) P301L Mutant PFFs (SPR-523) Order Human Tau (K18) P301L Mutant PFFs (SPR-523) from StressMarq. High-quality reagents for neurodegenerative disease research.

⭐New Product!⭐

StressMarq now provides Human Tau (K18) P301L Mutant Pre-formed Fibrils generated without heparin, offering an improved model for #tauopathy and #neurodegeneration studies. These PFFs induce neurotoxicity in primary mouse cortical neurons.

🔬Learn more here: http://bit.ly/46UZ4V1

Human Tau (K18) P301L Mutant PFFs (SPR-523) Order Human Tau (K18) P301L Mutant PFFs (SPR-523) from StressMarq. High-quality reagents for neurodegenerative disease research.

⭐New Product!⭐

StressMarq now provides Human Tau (K18) P301L Mutant Pre-formed Fibrils generated without heparin, offering an improved model for #tauopathy and #neurodegeneration studies. These PFFs induce neurotoxicity in primary mouse cortical neurons.

🔬Learn more here: http://bit.ly/46UZ4V1

Soluble tau aggregates decrease the threshold for thalamic oscillations and increase the excitability of thalamic neurons Sleep disturbances frequently occur early in dementias such as Alzheimer's disease (AD) and potentially arise from many factors including cortico-thal…

A new study shows soluble Tau aggregates may disrupt brain rhythms by making thalamic neurons more excitable

With rPeptide’s Tau-441 PFFs t.ly/p0Ykf, researchers modeled early Tau pathology in mice to reveal how these aggregates alter brain signaling

t.ly/Ss8w5

#Neuroscience #Tauopathy #Research

🧠 We report an optimized protocol to turn SH-SY5Y into cortical neuron-like cells for tau seeding & aggregation assays.
New tool for #Tauopathy studies.

🔗 doi.org/10.1007/s12035-025-05100-3

#Neurodegeneration #DrugDiscovery @ Palacky University Olomouc @ IMTM

Structural and functional insights into the selective inhibition of mutant tau aggregation by purpurin and oleocanthal in frontotemporal dementia Tau aggregation driven by microtubule-associated protein tau (MAPT) mutations is central to frontotemporal dementia pathology, yet no disease-modifying therapies effectively target mutant tau. Here, ...

🧠 New in Protein Science:
We show that purpurin & oleocanthal selectively inhibit mutant tau aggregation in frontotemporal dementia, blocking fibril formation & propagation.

🔗 doi.org/10.1002/pro.70240

#Neurodegeneration #Tauopathy #DrugDiscovery

Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia - Nature Immunology McGavern and colleagues identified a CD8+ T cell population that expresses GZMK in ʽtau-richʼ brains, where it may play a protective role against neurodegeneration.

"#innate and #adaptive (GZMK+CD8+ T cells) #immune cells mount a coordinated #neuroprotective response during development of a #tauopathy that #slows #disease #progression - in #mouse model www.nature.com/articles/s41...

Product Citation: StressMarq's #Tau-441 P301S Mutant PFFs played a role in elucidating the relationship between #neurodegeneration & #circadian rhythym dysfunction, in a PS19 mouse model of #tauopathy. 🐭🔬

Paper 📬 https://bit.ly/3HH1Jcd
Product 📦 https://bit.ly/3RdB0pI

Original post on mementomori.social

AlzForumin kevään konferenssi-koosteet:

AD/PD 2025:stä Wienissä, www.alzforum.org/news/conference-coverage...
Tau Globalista Lontoossa, www.alzforum.org/news/conference-coverage...

#alz #alzheimer #konferenssi #conference […]