-White Matter Integrity: Diffusion Tensor Imaging (DTI) showed reduced fractional anisotropy (FA) in the #corpuscallosum & #hippocampus, signifying axonal damage & #demyelination.
-The XBB.1 variant caused significant disruption to the olfactory bulb and entorhinal cortex,
#Lipid alterations in hereditary #peripheralneuropathies: common mechanisms in disease heterogeneity?
Koen Kuipers, Sam Vanherle, Kirsten Poelmans, Esther Wolfs, Jeroen Bogie & Tim Vangansewinkel #neurodegeneration #schwanncells #demyelination
link.springer.com/article/10.1...
DAP12 deletion reduces neuronal SLIT2 and #demyelination and enhances brain resilience in female #tauopathy mice
Hao Chen, Li Fan, Qi Guo...Li Gan & Wenjie Luo @liganlab.bsky.social @weillcornell.bsky.social #AlzheimersDisease
link.springer.com/article/10.1...
Left: An example image of a filled PV interneuron showing putative autapses with white arrows. Note that all autapses are present in close distance to the soma. Right: Pie charts depicting the percentage of cells showing (1) both structural and physiological autapses, (2) no structural nor physiological autapses, and (3) only structural autapses. Note that only mice that underwent juvenile demyelination have PV interneurons which show structural autapses but no autaptic response.
What role does #myelination play in #PrefrontalCortex development? This study shows that juvenile #demyelination disrupts PV #interneuron firing & self-inhibition, revealing a developmental window where myelination is essential for long-term cortical function @plosbiology.org 🧪 plos.io/4mI4lVO
Left: An example image of a filled PV interneuron showing putative autapses with white arrows. Note that all autapses are present in close distance to the soma. Right: Pie charts depicting the percentage of cells showing (1) both structural and physiological autapses, (2) no structural nor physiological autapses, and (3) only structural autapses. Note that only mice that underwent juvenile demyelination have PV interneurons which show structural autapses but no autaptic response.
What role does #myelination play in #PrefrontalCortex development? This study shows that juvenile #demyelination disrupts PV #interneuron firing & self-inhibition, revealing a developmental window where myelination is essential for long-term cortical function @plosbiology.org 🧪 plos.io/4mI4lVO
Left: An example image of a filled PV interneuron showing putative autapses with white arrows. Note that all autapses are present in close distance to the soma. Right: Pie charts depicting the percentage of cells showing (1) both structural and physiological autapses, (2) no structural nor physiological autapses, and (3) only structural autapses. Note that only mice that underwent juvenile demyelination have PV interneurons which show structural autapses but no autaptic response.
What role does #myelination play in #PrefrontalCortex development? This study shows that juvenile #demyelination disrupts PV #interneuron firing & self-inhibition, revealing a developmental window where myelination is essential for long-term cortical function @plosbiology.org 🧪 plos.io/4mI4lVO
#Medsky🧪 #IDsky #Neurosky #publicheal @jhumimmunity.org #casereport #LongCOVID frequently presents with neurological complications #NeuroCovid , including #neuroinflammation and #demyelination. Proinflammatory cytokines, particularly interleukin-18 (IL-18),
International Self-Care Day – July 24:
In support of Multiple Sclerosis (MS) research:
#BikeMS #CureMS #Demyelination #FightMS #FuckMS #FuckYouMS #FUMS #MS #MSawareness #MSeducation #MultipleSclerosis #MSHope #MSstrong #MSSucks #MSwarrior #WeAreStrongerThanMS #EndMS #July24 #InternationalSelfCareDay
"This series draws attention to [tumefactive #demyelination] as an uncommon cause of cerebral #lesions in #older patients. We highlight the importance of MRI and ancillary tests to diagnose TD and avoid invasive investigations."
doi.org/10.7224/1537...
Nerve fibers have a protective coating called myelin. Over time, conditions like multiple sclerosis damage myelin and then the nerve fibers themselves. This week’s blog post explores this process, called #demyelination.
📰 Read the blog buff.ly/FYHcKuC ⬇️
The Brain’s Immune System: Microglia and Inflammation Explained
#BrainScience #Neuroscience #GlialCells #Microglia #Astrocytes #Neuroinflammation #BrainHealth #Neurodegeneration #Demyelination #Cytokines #Neurons #BrainResearch #Neurobiology #BrainInjury #BrainRecovery
youtube.com/shorts/SrrJK...
Demyelination Produces a Shift in the Population of Cortical Neurons That Synapse with Callosal Oligodendrocyte Progenitor Cells
#neuro #oligodendroglia #OPC #myelination #remyelination #demyelination #neuron #synapse 🧪
doi.org/10.1523/ENEU...
A comparative #transcriptomic analysis of mouse #demyelination models and #MultipleSclerosis lesions
🐭🧠👤
#neuroskyence #neuroscience #compneurosky
www.biorxiv.org/content/10.1...
#PhenoTherapeutics #Firstinhumantrial #PTD802 #clinicaltrialauthorisation #CTA #smallmoleculetherapeutic #remyelination #multiplesclerosis #MS #neurology #selectiveGPR17antagonist #UCB #Demyelination #DemyelinationinMS #GPR17targetingremyelinationtherapeutics
pharmatimes.com/news/pheno-t...
mTOR activation augments autophagy impairment via ATG13 inactivation.
• Autophagy impairment induces IL-6 and RANTES via STAT3, demyelinates nerves in the muscle and spinal cord. #mTOR #Autophagy #Demyelination #NeuroMuscular #PEM #AnimalModel #MECFS
1/1Our findings demonstrate that sex is a critical modifier in #demyelination during #aging and with #tau pathology, particularly in the presence of the #APOE4 allele.
The sex differences observed can be driven by gonadal
In @science.org this week: Li Gan & colleagues show the X-linked gene #Tlr7 determines #SexDifferences in #demyelination. Moreover, depletion or inhibition of TLR7 protects against demyelination in mouse model of #tau- mediated demyelination!
Finding treatments that can repair myelin will complement treatments that aim to stop immune attacks and protect nerves themselves from damage.
mssoc.uk/47f3dSi
#MS #demyelination
